Products of Sericulture and Their Hypoglycemic Action Evaluated by Using the Silkworm, Bombyx mori (Lepidoptera: Bombycidae), as a Model

SIMPLE SUMMARY: The use of invertebrates as animal models is gaining attention within the scientific community due to numerous advantages during the development of the experiments, low cost of rearing, and fewer ethical problems. The well-documented biology of the silkworm (Bombyx mori) makes this insect an ideal candidate to be used in different fields of research. In this study, we demonstrated the feasibility of using the silkworm to evaluate the hypoglycemic action of various products of sericulture included in the diet after promoting glucose or sucrose-induced hyperglycemia in silkworms. The postprandial antihyperglycemic activity of fibroin, sericin, and powder made from pupae of silkworms is confirmed. These natural products are therefore ideal candidates for the prevention and treatment of diabetes, obesity, and other lifestyle-related diseases. ABSTRACT: Sericulture generates different natural products with potential medical applications. Silk peptides, worms, or even pupae are commonly employed in traditional Asian medicine with a wide variety of purposes, and some scientific work has been focused on their antidiabetic properties. This work evaluates the postprandial antihyperglycemic activity of fibroin, sericin, and powder made from either larvae or pupae of silkworms, and Bombyx mori L. (Lepidoptera: Bombycidae), employing the silkworm itself as an animal model. The results indicate a reduction in the glucose levels in hemolymph after sucrose or glucose-induced hyperglycemia when these products are included in the diet of the worms.