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The Chemical Composition and Health-Promoting Effects of the Grewia Species—A Systematic Review and Meta-Analysis

Globally grown and organoleptically appreciated Grewia species are known as sources of bioactive compounds that avert the risk of communicable and non-communicable diseases. Therefore, in recent years, the genus Grewia has attracted increasing scientific attention. This is the first systematic revie...

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Autores principales: Qamar, Muhammad, Akhtar, Saeed, Ismail, Tariq, Wahid, Muqeet, Barnard, Ross T., Esatbeyoglu, Tuba, Ziora, Zyta M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707743/
https://www.ncbi.nlm.nih.gov/pubmed/34960117
http://dx.doi.org/10.3390/nu13124565
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author Qamar, Muhammad
Akhtar, Saeed
Ismail, Tariq
Wahid, Muqeet
Barnard, Ross T.
Esatbeyoglu, Tuba
Ziora, Zyta M.
author_facet Qamar, Muhammad
Akhtar, Saeed
Ismail, Tariq
Wahid, Muqeet
Barnard, Ross T.
Esatbeyoglu, Tuba
Ziora, Zyta M.
author_sort Qamar, Muhammad
collection PubMed
description Globally grown and organoleptically appreciated Grewia species are known as sources of bioactive compounds that avert the risk of communicable and non-communicable diseases. Therefore, in recent years, the genus Grewia has attracted increasing scientific attention. This is the first systematic review which focusses primarily on the nutritional composition, phytochemical profile, pharmacological properties, and disease preventative role of Grewia species. The literature published from 1975 to 2021 was searched to retrieve relevant articles from databases such as Google Scholar, Scopus, PubMed, and Web of Science. Two independent reviewers carried out the screening, selection of articles, and data extraction. Of 815 references, 56 met our inclusion criteria. G. asiatica and G. optiva were the most frequently studied species. We found 167 chemical compounds from 12 Grewia species, allocated to 21 categories. Flavonoids represented 41.31% of the reported bioactive compounds, followed by protein and amino acids (10.7%), fats and fatty acids (9.58%), ash and minerals (6.58%), and non-flavonoid polyphenols (5.96%). Crude extracts, enriched with bioactive compounds, and isolated compounds from the Grewia species show antioxidant, anticancer, anti-inflammatory, antidiabetic, hepatoprotective/radioprotective, immunomodulatory, and sedative hypnotic potential. Moreover, antimicrobial properties, improvement in learning and memory deficits, and effectiveness against neurodegenerative ailments are also described within the reviewed article. Nowadays, the side effects of some synthetic drugs and therapies, and bottlenecks in the drug development pathway have directed the attention of researchers and pharmaceutical industries towards the development of new products that are safe, cost-effective, and readily available. However, the application of the Grewia species in pharmaceutical industries is still limited.
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spelling pubmed-87077432021-12-25 The Chemical Composition and Health-Promoting Effects of the Grewia Species—A Systematic Review and Meta-Analysis Qamar, Muhammad Akhtar, Saeed Ismail, Tariq Wahid, Muqeet Barnard, Ross T. Esatbeyoglu, Tuba Ziora, Zyta M. Nutrients Review Globally grown and organoleptically appreciated Grewia species are known as sources of bioactive compounds that avert the risk of communicable and non-communicable diseases. Therefore, in recent years, the genus Grewia has attracted increasing scientific attention. This is the first systematic review which focusses primarily on the nutritional composition, phytochemical profile, pharmacological properties, and disease preventative role of Grewia species. The literature published from 1975 to 2021 was searched to retrieve relevant articles from databases such as Google Scholar, Scopus, PubMed, and Web of Science. Two independent reviewers carried out the screening, selection of articles, and data extraction. Of 815 references, 56 met our inclusion criteria. G. asiatica and G. optiva were the most frequently studied species. We found 167 chemical compounds from 12 Grewia species, allocated to 21 categories. Flavonoids represented 41.31% of the reported bioactive compounds, followed by protein and amino acids (10.7%), fats and fatty acids (9.58%), ash and minerals (6.58%), and non-flavonoid polyphenols (5.96%). Crude extracts, enriched with bioactive compounds, and isolated compounds from the Grewia species show antioxidant, anticancer, anti-inflammatory, antidiabetic, hepatoprotective/radioprotective, immunomodulatory, and sedative hypnotic potential. Moreover, antimicrobial properties, improvement in learning and memory deficits, and effectiveness against neurodegenerative ailments are also described within the reviewed article. Nowadays, the side effects of some synthetic drugs and therapies, and bottlenecks in the drug development pathway have directed the attention of researchers and pharmaceutical industries towards the development of new products that are safe, cost-effective, and readily available. However, the application of the Grewia species in pharmaceutical industries is still limited. MDPI 2021-12-20 /pmc/articles/PMC8707743/ /pubmed/34960117 http://dx.doi.org/10.3390/nu13124565 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Qamar, Muhammad
Akhtar, Saeed
Ismail, Tariq
Wahid, Muqeet
Barnard, Ross T.
Esatbeyoglu, Tuba
Ziora, Zyta M.
The Chemical Composition and Health-Promoting Effects of the Grewia Species—A Systematic Review and Meta-Analysis
title The Chemical Composition and Health-Promoting Effects of the Grewia Species—A Systematic Review and Meta-Analysis
title_full The Chemical Composition and Health-Promoting Effects of the Grewia Species—A Systematic Review and Meta-Analysis
title_fullStr The Chemical Composition and Health-Promoting Effects of the Grewia Species—A Systematic Review and Meta-Analysis
title_full_unstemmed The Chemical Composition and Health-Promoting Effects of the Grewia Species—A Systematic Review and Meta-Analysis
title_short The Chemical Composition and Health-Promoting Effects of the Grewia Species—A Systematic Review and Meta-Analysis
title_sort chemical composition and health-promoting effects of the grewia species—a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707743/
https://www.ncbi.nlm.nih.gov/pubmed/34960117
http://dx.doi.org/10.3390/nu13124565
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