Cellular Response to Unfolded Proteins in Depression

Despite many scientific studies on depression, there is no clear conception explaining the causes and mechanisms of depression development. Research conducted in recent years has shown that there is a strong relationship between depression and the endoplasmic reticulum (ER) stress. In order to resto...

Descripción completa

Detalles Bibliográficos
Autores principales: Kowalczyk, Mateusz, Kowalczyk, Edward, Kwiatkowski, Paweł, Łopusiewicz, Łukasz, Talarowska, Monika, Sienkiewicz, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707777/
https://www.ncbi.nlm.nih.gov/pubmed/34947907
http://dx.doi.org/10.3390/life11121376
_version_ 1784622520625790976
author Kowalczyk, Mateusz
Kowalczyk, Edward
Kwiatkowski, Paweł
Łopusiewicz, Łukasz
Talarowska, Monika
Sienkiewicz, Monika
author_facet Kowalczyk, Mateusz
Kowalczyk, Edward
Kwiatkowski, Paweł
Łopusiewicz, Łukasz
Talarowska, Monika
Sienkiewicz, Monika
author_sort Kowalczyk, Mateusz
collection PubMed
description Despite many scientific studies on depression, there is no clear conception explaining the causes and mechanisms of depression development. Research conducted in recent years has shown that there is a strong relationship between depression and the endoplasmic reticulum (ER) stress. In order to restore ER homeostasis, the adaptive unfolded protein response (UPR) mechanism is activated. Research suggests that ER stress response pathways are continuously activated in patients with major depressive disorders (MDD). Therefore, it seems that the recommended drugs should reduce ER stress. A search is currently underway for drugs that will be both effective in reducing ER stress and relieving symptoms of depression.
format Online
Article
Text
id pubmed-8707777
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87077772021-12-25 Cellular Response to Unfolded Proteins in Depression Kowalczyk, Mateusz Kowalczyk, Edward Kwiatkowski, Paweł Łopusiewicz, Łukasz Talarowska, Monika Sienkiewicz, Monika Life (Basel) Review Despite many scientific studies on depression, there is no clear conception explaining the causes and mechanisms of depression development. Research conducted in recent years has shown that there is a strong relationship between depression and the endoplasmic reticulum (ER) stress. In order to restore ER homeostasis, the adaptive unfolded protein response (UPR) mechanism is activated. Research suggests that ER stress response pathways are continuously activated in patients with major depressive disorders (MDD). Therefore, it seems that the recommended drugs should reduce ER stress. A search is currently underway for drugs that will be both effective in reducing ER stress and relieving symptoms of depression. MDPI 2021-12-10 /pmc/articles/PMC8707777/ /pubmed/34947907 http://dx.doi.org/10.3390/life11121376 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kowalczyk, Mateusz
Kowalczyk, Edward
Kwiatkowski, Paweł
Łopusiewicz, Łukasz
Talarowska, Monika
Sienkiewicz, Monika
Cellular Response to Unfolded Proteins in Depression
title Cellular Response to Unfolded Proteins in Depression
title_full Cellular Response to Unfolded Proteins in Depression
title_fullStr Cellular Response to Unfolded Proteins in Depression
title_full_unstemmed Cellular Response to Unfolded Proteins in Depression
title_short Cellular Response to Unfolded Proteins in Depression
title_sort cellular response to unfolded proteins in depression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707777/
https://www.ncbi.nlm.nih.gov/pubmed/34947907
http://dx.doi.org/10.3390/life11121376
work_keys_str_mv AT kowalczykmateusz cellularresponsetounfoldedproteinsindepression
AT kowalczykedward cellularresponsetounfoldedproteinsindepression
AT kwiatkowskipaweł cellularresponsetounfoldedproteinsindepression
AT łopusiewiczłukasz cellularresponsetounfoldedproteinsindepression
AT talarowskamonika cellularresponsetounfoldedproteinsindepression
AT sienkiewiczmonika cellularresponsetounfoldedproteinsindepression

Ejemplares similares