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A Conserved Allosteric Site on Drug-Metabolizing CYPs: A Systematic Computational Assessment
Cytochrome P450 enzymes (CYPs) are the largest group of enzymes involved in human drug metabolism. Ligand tunnels connect their active site buried at the core of the membrane-anchored protein to the surrounding solvent environment. Recently, evidence of a superficial allosteric site, here denoted as...
Autores principales: | Fischer, André, Smieško, Martin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707821/ https://www.ncbi.nlm.nih.gov/pubmed/34948012 http://dx.doi.org/10.3390/ijms222413215 |
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