Cargando…

Probing In Silico the Benzimidazole Privileged Scaffold for the Development of Drug-like Anti-RSV Agents

Targeting the fusion (F) protein has been recognized as a fruitful strategy for the development of anti-RSV agents. Despite the considerable efforts so far put into the development of RSV F protein inhibitors, the discovery of adequate therapeutics for the treatment of RSV infections is still awaiti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cichero, Elena, Calautti, Alessio, Francesconi, Valeria, Tonelli, Michele, Schenone, Silvia, Fossa, Paola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707824/ https://www.ncbi.nlm.nih.gov/pubmed/34959708 http://dx.doi.org/10.3390/ph14121307

Ejemplares similares

Benzimidazole-based derivatives as privileged scaffold developed for the treatment of the RSV infection: a computational study exploring the potency and cytotoxicity profiles
por: Cichero, Elena, et al.
Publicado: (2017)

Synthesis and Biological Evaluation of Novel (thio)semicarbazone-Based Benzimidazoles as Antiviral Agents against Human Respiratory Viruses
por: Francesconi, Valeria, et al.
Publicado: (2020)

Green Synthesis of Privileged Benzimidazole Scaffolds Using Active Deep Eutectic Solvent
por: Di Gioia, Maria Luisa, et al.
Publicado: (2019)

In-silico molecular design of heterocyclic benzimidazole scaffolds as prospective anticancer agents
por: Tahlan, Sumit, et al.
Publicado: (2019)

Indol-3-ylglyoxylamide as Privileged Scaffold in Medicinal Chemistry
por: Barresi, Elisabetta, et al.
Publicado: (2023)

Journey on Naphthoquinone and Anthraquinone Derivatives: New Insights in Alzheimer’s Disease
por: Campora, Marta, et al.
Publicado: (2021)

Benzimidazole scaffolds as promising antiproliferative agents: a review
por: Tahlan, Sumit, et al.
Publicado: (2019)

Exhaustive CoMFA and CoMSIA analyses around different chemical entities: a ligand-based study exploring the affinity and selectivity profiles of 5-HT(1A) ligands
por: Guariento, Sara, et al.
Publicado: (2017)

Synthesis, biological evaluation and molecular modeling of novel azaspiro dihydrotriazines as influenza virus inhibitors targeting the host factor dihydrofolate reductase (DHFR)
por: Francesconi, Valeria, et al.
Publicado: (2018)

Virtual Screening Combined with Enzymatic Assays to Guide the Discovery of Novel SIRT2 Inhibitors
por: Scarano, Naomi, et al.
Publicado: (2023)

Aminated Quinolinequinones as Privileged Scaffolds for Antibacterial Agents: Synthesis, In Vitro Evaluation, and Putative Mode of Action
por: Yıldırım, Hatice, et al.
Publicado: (2022)

LmrR: A Privileged Scaffold for Artificial Metalloenzymes
por: Roelfes, Gerard
Publicado: (2019)

Novel 1-Amidino-4-Phenylpiperazines as Potent Agonists at Human TAAR1 Receptor: Rational Design, Synthesis, Biological Evaluation and Molecular Docking Studies
por: Francesconi, Valeria, et al.
Publicado: (2020)

Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors
por: Melis, Claudia, et al.
Publicado: (2016)

Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds
por: Stefanachi, Angela, et al.
Publicado: (2018)

The Fellowship of Privileged Scaffolds—One Structure to Inhibit Them All
por: Skoreński, Marcin, et al.
Publicado: (2021)

Pyrroles as Privileged Scaffolds in the Search for New Potential HIV Inhibitors
por: Bianco, Maria da Conceição Avelino Dias, et al.
Publicado: (2021)

An overview of metal-free synthetic routes to isoxazoles: the privileged scaffold
por: Das, Soumyadip, et al.
Publicado: (2021)

New Insights into the Binding Features of F508del CFTR Potentiators: A Molecular Docking, Pharmacophore Mapping and QSAR Analysis Approach
por: Righetti, Giada, et al.
Publicado: (2020)

Privileged Scaffolds for Potent and Specific Inhibitors of Mono-ADP-Ribosylating PARPs
por: Nizi, Maria Giulia, et al.
Publicado: (2023)

Flavonoids and related privileged scaffolds as potential urease inhibitors: a review
por: Al-Rooqi, Munirah M., et al.
Publicado: (2023)

Priviléges /
por: Beauvoir, Simone de, 1908-1986
Publicado: (1955)

Privileges
por: Jagannathan, Mukund
Publicado: (2016)

N,2,6-Trisubstituted 1H-benzimidazole derivatives as a new scaffold of antimicrobial and anticancer agents: design, synthesis, in vitro evaluation, and in silico studies
por: Pham, Em Canh, et al.
Publicado: (2022)

New arylsparteine derivatives as positive inotropic drugs
por: Boido, Vito, et al.
Publicado: (2017)

In silico comparative structural and compositional analysis of glycoproteins of RSV to study the nature of stability and transmissibility of RSV A
por: Mitra, Debanjan, et al.
Publicado: (2022)

3-Phenylcoumarins as a Privileged Scaffold in Medicinal Chemistry: The Landmarks of the Past Decade
por: Matos, Maria J., et al.
Publicado: (2021)

The privileged immunity of immune privileged organs: the case of the eye
por: Benhar, Inbal, et al.
Publicado: (2012)

Magnolol and Luteolin Inhibition of α-Glucosidase Activity: Kinetics and Type of Interaction Detected by In Vitro and In Silico Studies
por: Djeujo, Francine Medjiofack, et al.
Publicado: (2022)

Identification of new benzimidazole-triazole hybrids as anticancer agents: multi-target recognition, in vitro and in silico studies
por: Othman, Dina I. A., et al.
Publicado: (2023)

Benzimidazole derivatives endowed with potent antileishmanial activity
por: Tonelli, Michele, et al.
Publicado: (2017)

Molecular Docking and QSAR Studies as Computational Tools Exploring the Rescue Ability of F508del CFTR Correctors
por: Righetti, Giada, et al.
Publicado: (2020)

The Privilege of Suffering
Publicado: (1886)

The Privilege of Suffering
Publicado: (1886)

Ransomware and Privileges
por: Haber, Morey J.
Publicado: (2020)

Privileged Communications
Publicado: (1852)

Privileged Scaffold Decoration for the Identification of the First Trisubstituted Triazine with Anti-SARS-CoV-2 Activity
por: Cesarini, Silvia, et al.
Publicado: (2022)

Alternative Benzoxazole Assembly Discovered in Anaerobic Bacteria Provides Access to Privileged Heterocyclic Scaffold
por: Horch, Therese, et al.
Publicado: (2022)

Manipulations of phenylnorbornyl palladium species for multicomponent construction of a bridged polycyclic privileged scaffold
por: Yin, Lina, et al.
Publicado: (2022)

Discovery of Guanfacine as a Novel TAAR1 Agonist: A Combination Strategy through Molecular Modeling Studies and Biological Assays
por: Cichero, Elena, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_j7g3g6msl9alk22ibp0l09erpq