Physicochemical and Biological Study of (99m)Tc and (68)Ga Radiolabelled Ciprofloxacin and Evaluation of [(99m)Tc]Tc-CIP as Potential Diagnostic Radiopharmaceutical for Diabetic Foot Syndrome Imaging

This paper presents the application of ciprofloxacin as a biologically active molecule (vector) for delivering diagnostic radiopharmaceuticals to the sites of bacterial infection. Ciprofloxacin-based radioconjugates containing technetium-99m or gallium-68 radionuclides were synthesised, and their ph...

Descripción completa

Detalles Bibliográficos
Autores principales: Koźmiński, Przemysław, Gawęda, Weronika, Rzewuska, Magdalena, Kopatys, Agata, Kujda, Szymon, Dudek, Marta K., Halik, Paweł Krzysztof, Królicki, Leszek, Gniazdowska, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707861/
https://www.ncbi.nlm.nih.gov/pubmed/34941642
http://dx.doi.org/10.3390/tomography7040070
Descripción
Sumario:This paper presents the application of ciprofloxacin as a biologically active molecule (vector) for delivering diagnostic radiopharmaceuticals to the sites of bacterial infection. Ciprofloxacin-based radioconjugates containing technetium-99m or gallium-68 radionuclides were synthesised, and their physicochemical (stability, lipophilicity) and biological (binding study to Staphylococcus aureus and Pseudomonas aeruginosa) properties were investigated. Both the tested radiopreparations met the requirements for radiopharmaceuticals, and technetium-99m-labelled ciprofloxacin turned out to be a good radiotracer for the tomography of diabetic foot syndrome using SPECT.

Ejemplares similares