Physicochemical and Biological Study of (99m)Tc and (68)Ga Radiolabelled Ciprofloxacin and Evaluation of [(99m)Tc]Tc-CIP as Potential Diagnostic Radiopharmaceutical for Diabetic Foot Syndrome Imaging

This paper presents the application of ciprofloxacin as a biologically active molecule (vector) for delivering diagnostic radiopharmaceuticals to the sites of bacterial infection. Ciprofloxacin-based radioconjugates containing technetium-99m or gallium-68 radionuclides were synthesised, and their ph...

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Autores principales: Koźmiński, Przemysław, Gawęda, Weronika, Rzewuska, Magdalena, Kopatys, Agata, Kujda, Szymon, Dudek, Marta K., Halik, Paweł Krzysztof, Królicki, Leszek, Gniazdowska, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707861/
https://www.ncbi.nlm.nih.gov/pubmed/34941642
http://dx.doi.org/10.3390/tomography7040070
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author Koźmiński, Przemysław
Gawęda, Weronika
Rzewuska, Magdalena
Kopatys, Agata
Kujda, Szymon
Dudek, Marta K.
Halik, Paweł Krzysztof
Królicki, Leszek
Gniazdowska, Ewa
author_facet Koźmiński, Przemysław
Gawęda, Weronika
Rzewuska, Magdalena
Kopatys, Agata
Kujda, Szymon
Dudek, Marta K.
Halik, Paweł Krzysztof
Królicki, Leszek
Gniazdowska, Ewa
author_sort Koźmiński, Przemysław
collection PubMed
description This paper presents the application of ciprofloxacin as a biologically active molecule (vector) for delivering diagnostic radiopharmaceuticals to the sites of bacterial infection. Ciprofloxacin-based radioconjugates containing technetium-99m or gallium-68 radionuclides were synthesised, and their physicochemical (stability, lipophilicity) and biological (binding study to Staphylococcus aureus and Pseudomonas aeruginosa) properties were investigated. Both the tested radiopreparations met the requirements for radiopharmaceuticals, and technetium-99m-labelled ciprofloxacin turned out to be a good radiotracer for the tomography of diabetic foot syndrome using SPECT.
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spelling pubmed-87078612021-12-25 Physicochemical and Biological Study of (99m)Tc and (68)Ga Radiolabelled Ciprofloxacin and Evaluation of [(99m)Tc]Tc-CIP as Potential Diagnostic Radiopharmaceutical for Diabetic Foot Syndrome Imaging Koźmiński, Przemysław Gawęda, Weronika Rzewuska, Magdalena Kopatys, Agata Kujda, Szymon Dudek, Marta K. Halik, Paweł Krzysztof Królicki, Leszek Gniazdowska, Ewa Tomography Article This paper presents the application of ciprofloxacin as a biologically active molecule (vector) for delivering diagnostic radiopharmaceuticals to the sites of bacterial infection. Ciprofloxacin-based radioconjugates containing technetium-99m or gallium-68 radionuclides were synthesised, and their physicochemical (stability, lipophilicity) and biological (binding study to Staphylococcus aureus and Pseudomonas aeruginosa) properties were investigated. Both the tested radiopreparations met the requirements for radiopharmaceuticals, and technetium-99m-labelled ciprofloxacin turned out to be a good radiotracer for the tomography of diabetic foot syndrome using SPECT. MDPI 2021-12-01 /pmc/articles/PMC8707861/ /pubmed/34941642 http://dx.doi.org/10.3390/tomography7040070 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Koźmiński, Przemysław
Gawęda, Weronika
Rzewuska, Magdalena
Kopatys, Agata
Kujda, Szymon
Dudek, Marta K.
Halik, Paweł Krzysztof
Królicki, Leszek
Gniazdowska, Ewa
Physicochemical and Biological Study of (99m)Tc and (68)Ga Radiolabelled Ciprofloxacin and Evaluation of [(99m)Tc]Tc-CIP as Potential Diagnostic Radiopharmaceutical for Diabetic Foot Syndrome Imaging
title Physicochemical and Biological Study of (99m)Tc and (68)Ga Radiolabelled Ciprofloxacin and Evaluation of [(99m)Tc]Tc-CIP as Potential Diagnostic Radiopharmaceutical for Diabetic Foot Syndrome Imaging
title_full Physicochemical and Biological Study of (99m)Tc and (68)Ga Radiolabelled Ciprofloxacin and Evaluation of [(99m)Tc]Tc-CIP as Potential Diagnostic Radiopharmaceutical for Diabetic Foot Syndrome Imaging
title_fullStr Physicochemical and Biological Study of (99m)Tc and (68)Ga Radiolabelled Ciprofloxacin and Evaluation of [(99m)Tc]Tc-CIP as Potential Diagnostic Radiopharmaceutical for Diabetic Foot Syndrome Imaging
title_full_unstemmed Physicochemical and Biological Study of (99m)Tc and (68)Ga Radiolabelled Ciprofloxacin and Evaluation of [(99m)Tc]Tc-CIP as Potential Diagnostic Radiopharmaceutical for Diabetic Foot Syndrome Imaging
title_short Physicochemical and Biological Study of (99m)Tc and (68)Ga Radiolabelled Ciprofloxacin and Evaluation of [(99m)Tc]Tc-CIP as Potential Diagnostic Radiopharmaceutical for Diabetic Foot Syndrome Imaging
title_sort physicochemical and biological study of (99m)tc and (68)ga radiolabelled ciprofloxacin and evaluation of [(99m)tc]tc-cip as potential diagnostic radiopharmaceutical for diabetic foot syndrome imaging
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707861/
https://www.ncbi.nlm.nih.gov/pubmed/34941642
http://dx.doi.org/10.3390/tomography7040070
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