Entrectinib—A SARS-CoV-2 Inhibitor in Human Lung Tissue (HLT) Cells

Since the start of the COVID-19 outbreak, pharmaceutical companies and research groups have focused on the development of vaccines and antiviral drugs against SARS-CoV-2. Here, we apply a drug repurposing strategy to identify drug candidates that are able to block the entrance of the virus into huma...

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Autores principales: Peralta-Garcia, Alejandro, Torrens-Fontanals, Mariona, Stepniewski, Tomasz Maciej, Grau-Expósito, Judith, Perea, David, Ayinampudi, Vikram, Waldhoer, Maria, Zimmermann, Mirjam, Buzón, María J., Genescà, Meritxell, Selent, Jana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707862/
https://www.ncbi.nlm.nih.gov/pubmed/34948390
http://dx.doi.org/10.3390/ijms222413592
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author Peralta-Garcia, Alejandro
Torrens-Fontanals, Mariona
Stepniewski, Tomasz Maciej
Grau-Expósito, Judith
Perea, David
Ayinampudi, Vikram
Waldhoer, Maria
Zimmermann, Mirjam
Buzón, María J.
Genescà, Meritxell
Selent, Jana
author_facet Peralta-Garcia, Alejandro
Torrens-Fontanals, Mariona
Stepniewski, Tomasz Maciej
Grau-Expósito, Judith
Perea, David
Ayinampudi, Vikram
Waldhoer, Maria
Zimmermann, Mirjam
Buzón, María J.
Genescà, Meritxell
Selent, Jana
author_sort Peralta-Garcia, Alejandro
collection PubMed
description Since the start of the COVID-19 outbreak, pharmaceutical companies and research groups have focused on the development of vaccines and antiviral drugs against SARS-CoV-2. Here, we apply a drug repurposing strategy to identify drug candidates that are able to block the entrance of the virus into human cells. By combining virtual screening with in vitro pseudovirus assays and antiviral assays in Human Lung Tissue (HLT) cells, we identify entrectinib as a potential antiviral drug.
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spelling pubmed-87078622021-12-25 Entrectinib—A SARS-CoV-2 Inhibitor in Human Lung Tissue (HLT) Cells Peralta-Garcia, Alejandro Torrens-Fontanals, Mariona Stepniewski, Tomasz Maciej Grau-Expósito, Judith Perea, David Ayinampudi, Vikram Waldhoer, Maria Zimmermann, Mirjam Buzón, María J. Genescà, Meritxell Selent, Jana Int J Mol Sci Communication Since the start of the COVID-19 outbreak, pharmaceutical companies and research groups have focused on the development of vaccines and antiviral drugs against SARS-CoV-2. Here, we apply a drug repurposing strategy to identify drug candidates that are able to block the entrance of the virus into human cells. By combining virtual screening with in vitro pseudovirus assays and antiviral assays in Human Lung Tissue (HLT) cells, we identify entrectinib as a potential antiviral drug. MDPI 2021-12-18 /pmc/articles/PMC8707862/ /pubmed/34948390 http://dx.doi.org/10.3390/ijms222413592 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Peralta-Garcia, Alejandro
Torrens-Fontanals, Mariona
Stepniewski, Tomasz Maciej
Grau-Expósito, Judith
Perea, David
Ayinampudi, Vikram
Waldhoer, Maria
Zimmermann, Mirjam
Buzón, María J.
Genescà, Meritxell
Selent, Jana
Entrectinib—A SARS-CoV-2 Inhibitor in Human Lung Tissue (HLT) Cells
title Entrectinib—A SARS-CoV-2 Inhibitor in Human Lung Tissue (HLT) Cells
title_full Entrectinib—A SARS-CoV-2 Inhibitor in Human Lung Tissue (HLT) Cells
title_fullStr Entrectinib—A SARS-CoV-2 Inhibitor in Human Lung Tissue (HLT) Cells
title_full_unstemmed Entrectinib—A SARS-CoV-2 Inhibitor in Human Lung Tissue (HLT) Cells
title_short Entrectinib—A SARS-CoV-2 Inhibitor in Human Lung Tissue (HLT) Cells
title_sort entrectinib—a sars-cov-2 inhibitor in human lung tissue (hlt) cells
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707862/
https://www.ncbi.nlm.nih.gov/pubmed/34948390
http://dx.doi.org/10.3390/ijms222413592
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