Cargando…
Monocyte/Lymphocyte Ratio and MCHC as Predictors of Collateral Carotid Artery Disease—Preliminary Report
Background: Carotid artery disease accounts for 30% of ischemic strokes in the general population. Numerous biomarkers have been investigated for predicting either the progression or the severity of the disease. The aim of this retrospective study was to compare hematologic indices among patients re...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707882/ https://www.ncbi.nlm.nih.gov/pubmed/34945738 http://dx.doi.org/10.3390/jpm11121266 |
_version_ | 1784622546887376896 |
---|---|
author | Urbanowicz, Tomasz Michalak, Michał Olasińska-Wiśniewska, Anna Rodzki, Michał Krasińska, Aleksandra Perek, Bartłomiej Krasiński, Zbigniew Jemielity, Marek |
author_facet | Urbanowicz, Tomasz Michalak, Michał Olasińska-Wiśniewska, Anna Rodzki, Michał Krasińska, Aleksandra Perek, Bartłomiej Krasiński, Zbigniew Jemielity, Marek |
author_sort | Urbanowicz, Tomasz |
collection | PubMed |
description | Background: Carotid artery disease accounts for 30% of ischemic strokes in the general population. Numerous biomarkers have been investigated for predicting either the progression or the severity of the disease. The aim of this retrospective study was to compare hematologic indices among patients referred for surgical interventions due to severe carotid disease. Methods: In total, 135 patients (87 (64.4%) men and 48 (35.6%) women) with a mean age of 70 ± 8 years who underwent surgical carotid intervention were enrolled into the study. Results: A Mann–Whitney test for independent samples revealed significant differences in monocyte to lymphocyte ratio (MLR) and mean corpuscular hemoglobin concentration (MCHC) between patients with one and two (collateral) carotid diseases. The cut-off value for MLR was 0.3 (AUC = 0.654, p = 0.048, 70.0% sensitivity and 74.6% specificity) and for MHCH was 21.6. (AUC = 0.730, p < 0.001, 70.0% sensitivity and 77.2% specificity). A multivariable model of logistic regression revealed two significant parameters for collateral carotid stenosis disease including MLR > 0.3 (OR 6.19 with 95% CI 2.02–19.01, p = 0.001) and MCHC > 21.6 (OR 7.76, 95% CI 2.54–23.72, p < 0.001). Conclusions: MLR above 0.3 and MCHC above 21.6 have predictive values for colleterial carotid stenosis and may be used as easily accessible indicators for atherosclerosis severity. |
format | Online Article Text |
id | pubmed-8707882 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87078822021-12-25 Monocyte/Lymphocyte Ratio and MCHC as Predictors of Collateral Carotid Artery Disease—Preliminary Report Urbanowicz, Tomasz Michalak, Michał Olasińska-Wiśniewska, Anna Rodzki, Michał Krasińska, Aleksandra Perek, Bartłomiej Krasiński, Zbigniew Jemielity, Marek J Pers Med Article Background: Carotid artery disease accounts for 30% of ischemic strokes in the general population. Numerous biomarkers have been investigated for predicting either the progression or the severity of the disease. The aim of this retrospective study was to compare hematologic indices among patients referred for surgical interventions due to severe carotid disease. Methods: In total, 135 patients (87 (64.4%) men and 48 (35.6%) women) with a mean age of 70 ± 8 years who underwent surgical carotid intervention were enrolled into the study. Results: A Mann–Whitney test for independent samples revealed significant differences in monocyte to lymphocyte ratio (MLR) and mean corpuscular hemoglobin concentration (MCHC) between patients with one and two (collateral) carotid diseases. The cut-off value for MLR was 0.3 (AUC = 0.654, p = 0.048, 70.0% sensitivity and 74.6% specificity) and for MHCH was 21.6. (AUC = 0.730, p < 0.001, 70.0% sensitivity and 77.2% specificity). A multivariable model of logistic regression revealed two significant parameters for collateral carotid stenosis disease including MLR > 0.3 (OR 6.19 with 95% CI 2.02–19.01, p = 0.001) and MCHC > 21.6 (OR 7.76, 95% CI 2.54–23.72, p < 0.001). Conclusions: MLR above 0.3 and MCHC above 21.6 have predictive values for colleterial carotid stenosis and may be used as easily accessible indicators for atherosclerosis severity. MDPI 2021-12-01 /pmc/articles/PMC8707882/ /pubmed/34945738 http://dx.doi.org/10.3390/jpm11121266 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Urbanowicz, Tomasz Michalak, Michał Olasińska-Wiśniewska, Anna Rodzki, Michał Krasińska, Aleksandra Perek, Bartłomiej Krasiński, Zbigniew Jemielity, Marek Monocyte/Lymphocyte Ratio and MCHC as Predictors of Collateral Carotid Artery Disease—Preliminary Report |
title | Monocyte/Lymphocyte Ratio and MCHC as Predictors of Collateral Carotid Artery Disease—Preliminary Report |
title_full | Monocyte/Lymphocyte Ratio and MCHC as Predictors of Collateral Carotid Artery Disease—Preliminary Report |
title_fullStr | Monocyte/Lymphocyte Ratio and MCHC as Predictors of Collateral Carotid Artery Disease—Preliminary Report |
title_full_unstemmed | Monocyte/Lymphocyte Ratio and MCHC as Predictors of Collateral Carotid Artery Disease—Preliminary Report |
title_short | Monocyte/Lymphocyte Ratio and MCHC as Predictors of Collateral Carotid Artery Disease—Preliminary Report |
title_sort | monocyte/lymphocyte ratio and mchc as predictors of collateral carotid artery disease—preliminary report |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707882/ https://www.ncbi.nlm.nih.gov/pubmed/34945738 http://dx.doi.org/10.3390/jpm11121266 |
work_keys_str_mv | AT urbanowicztomasz monocytelymphocyteratioandmchcaspredictorsofcollateralcarotidarterydiseasepreliminaryreport AT michalakmichał monocytelymphocyteratioandmchcaspredictorsofcollateralcarotidarterydiseasepreliminaryreport AT olasinskawisniewskaanna monocytelymphocyteratioandmchcaspredictorsofcollateralcarotidarterydiseasepreliminaryreport AT rodzkimichał monocytelymphocyteratioandmchcaspredictorsofcollateralcarotidarterydiseasepreliminaryreport AT krasinskaaleksandra monocytelymphocyteratioandmchcaspredictorsofcollateralcarotidarterydiseasepreliminaryreport AT perekbartłomiej monocytelymphocyteratioandmchcaspredictorsofcollateralcarotidarterydiseasepreliminaryreport AT krasinskizbigniew monocytelymphocyteratioandmchcaspredictorsofcollateralcarotidarterydiseasepreliminaryreport AT jemielitymarek monocytelymphocyteratioandmchcaspredictorsofcollateralcarotidarterydiseasepreliminaryreport |