Cargando…

Monocyte/Lymphocyte Ratio and MCHC as Predictors of Collateral Carotid Artery Disease—Preliminary Report

Background: Carotid artery disease accounts for 30% of ischemic strokes in the general population. Numerous biomarkers have been investigated for predicting either the progression or the severity of the disease. The aim of this retrospective study was to compare hematologic indices among patients re...

Descripción completa

Detalles Bibliográficos
Autores principales: Urbanowicz, Tomasz, Michalak, Michał, Olasińska-Wiśniewska, Anna, Rodzki, Michał, Krasińska, Aleksandra, Perek, Bartłomiej, Krasiński, Zbigniew, Jemielity, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707882/
https://www.ncbi.nlm.nih.gov/pubmed/34945738
http://dx.doi.org/10.3390/jpm11121266
_version_ 1784622546887376896
author Urbanowicz, Tomasz
Michalak, Michał
Olasińska-Wiśniewska, Anna
Rodzki, Michał
Krasińska, Aleksandra
Perek, Bartłomiej
Krasiński, Zbigniew
Jemielity, Marek
author_facet Urbanowicz, Tomasz
Michalak, Michał
Olasińska-Wiśniewska, Anna
Rodzki, Michał
Krasińska, Aleksandra
Perek, Bartłomiej
Krasiński, Zbigniew
Jemielity, Marek
author_sort Urbanowicz, Tomasz
collection PubMed
description Background: Carotid artery disease accounts for 30% of ischemic strokes in the general population. Numerous biomarkers have been investigated for predicting either the progression or the severity of the disease. The aim of this retrospective study was to compare hematologic indices among patients referred for surgical interventions due to severe carotid disease. Methods: In total, 135 patients (87 (64.4%) men and 48 (35.6%) women) with a mean age of 70 ± 8 years who underwent surgical carotid intervention were enrolled into the study. Results: A Mann–Whitney test for independent samples revealed significant differences in monocyte to lymphocyte ratio (MLR) and mean corpuscular hemoglobin concentration (MCHC) between patients with one and two (collateral) carotid diseases. The cut-off value for MLR was 0.3 (AUC = 0.654, p = 0.048, 70.0% sensitivity and 74.6% specificity) and for MHCH was 21.6. (AUC = 0.730, p < 0.001, 70.0% sensitivity and 77.2% specificity). A multivariable model of logistic regression revealed two significant parameters for collateral carotid stenosis disease including MLR > 0.3 (OR 6.19 with 95% CI 2.02–19.01, p = 0.001) and MCHC > 21.6 (OR 7.76, 95% CI 2.54–23.72, p < 0.001). Conclusions: MLR above 0.3 and MCHC above 21.6 have predictive values for colleterial carotid stenosis and may be used as easily accessible indicators for atherosclerosis severity.
format Online
Article
Text
id pubmed-8707882
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87078822021-12-25 Monocyte/Lymphocyte Ratio and MCHC as Predictors of Collateral Carotid Artery Disease—Preliminary Report Urbanowicz, Tomasz Michalak, Michał Olasińska-Wiśniewska, Anna Rodzki, Michał Krasińska, Aleksandra Perek, Bartłomiej Krasiński, Zbigniew Jemielity, Marek J Pers Med Article Background: Carotid artery disease accounts for 30% of ischemic strokes in the general population. Numerous biomarkers have been investigated for predicting either the progression or the severity of the disease. The aim of this retrospective study was to compare hematologic indices among patients referred for surgical interventions due to severe carotid disease. Methods: In total, 135 patients (87 (64.4%) men and 48 (35.6%) women) with a mean age of 70 ± 8 years who underwent surgical carotid intervention were enrolled into the study. Results: A Mann–Whitney test for independent samples revealed significant differences in monocyte to lymphocyte ratio (MLR) and mean corpuscular hemoglobin concentration (MCHC) between patients with one and two (collateral) carotid diseases. The cut-off value for MLR was 0.3 (AUC = 0.654, p = 0.048, 70.0% sensitivity and 74.6% specificity) and for MHCH was 21.6. (AUC = 0.730, p < 0.001, 70.0% sensitivity and 77.2% specificity). A multivariable model of logistic regression revealed two significant parameters for collateral carotid stenosis disease including MLR > 0.3 (OR 6.19 with 95% CI 2.02–19.01, p = 0.001) and MCHC > 21.6 (OR 7.76, 95% CI 2.54–23.72, p < 0.001). Conclusions: MLR above 0.3 and MCHC above 21.6 have predictive values for colleterial carotid stenosis and may be used as easily accessible indicators for atherosclerosis severity. MDPI 2021-12-01 /pmc/articles/PMC8707882/ /pubmed/34945738 http://dx.doi.org/10.3390/jpm11121266 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Urbanowicz, Tomasz
Michalak, Michał
Olasińska-Wiśniewska, Anna
Rodzki, Michał
Krasińska, Aleksandra
Perek, Bartłomiej
Krasiński, Zbigniew
Jemielity, Marek
Monocyte/Lymphocyte Ratio and MCHC as Predictors of Collateral Carotid Artery Disease—Preliminary Report
title Monocyte/Lymphocyte Ratio and MCHC as Predictors of Collateral Carotid Artery Disease—Preliminary Report
title_full Monocyte/Lymphocyte Ratio and MCHC as Predictors of Collateral Carotid Artery Disease—Preliminary Report
title_fullStr Monocyte/Lymphocyte Ratio and MCHC as Predictors of Collateral Carotid Artery Disease—Preliminary Report
title_full_unstemmed Monocyte/Lymphocyte Ratio and MCHC as Predictors of Collateral Carotid Artery Disease—Preliminary Report
title_short Monocyte/Lymphocyte Ratio and MCHC as Predictors of Collateral Carotid Artery Disease—Preliminary Report
title_sort monocyte/lymphocyte ratio and mchc as predictors of collateral carotid artery disease—preliminary report
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707882/
https://www.ncbi.nlm.nih.gov/pubmed/34945738
http://dx.doi.org/10.3390/jpm11121266
work_keys_str_mv AT urbanowicztomasz monocytelymphocyteratioandmchcaspredictorsofcollateralcarotidarterydiseasepreliminaryreport
AT michalakmichał monocytelymphocyteratioandmchcaspredictorsofcollateralcarotidarterydiseasepreliminaryreport
AT olasinskawisniewskaanna monocytelymphocyteratioandmchcaspredictorsofcollateralcarotidarterydiseasepreliminaryreport
AT rodzkimichał monocytelymphocyteratioandmchcaspredictorsofcollateralcarotidarterydiseasepreliminaryreport
AT krasinskaaleksandra monocytelymphocyteratioandmchcaspredictorsofcollateralcarotidarterydiseasepreliminaryreport
AT perekbartłomiej monocytelymphocyteratioandmchcaspredictorsofcollateralcarotidarterydiseasepreliminaryreport
AT krasinskizbigniew monocytelymphocyteratioandmchcaspredictorsofcollateralcarotidarterydiseasepreliminaryreport
AT jemielitymarek monocytelymphocyteratioandmchcaspredictorsofcollateralcarotidarterydiseasepreliminaryreport