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Biocompatible Diselenide-Containing Protein Hydrogels with Effective Visible-Light-Initiated Self-Healing Properties

Smart hydrogels are typical functional soft materials, but their functional and mechanical properties are compromised upon micro- or macro-mechanical damage. In contrast, hydrogels with self-healing properties overcome this limitation. Herein, a dual dynamic bind, cross-linked, self-healing protein...

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Autores principales: Liu, Shengda, Deng, Shengchao, Yan, Tengfei, Zhang, Xin, Tian, Ruizhen, Xu, Jiayun, Sun, Hongcheng, Yu, Shuangjiang, Liu, Junqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707953/
https://www.ncbi.nlm.nih.gov/pubmed/34960914
http://dx.doi.org/10.3390/polym13244360
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author Liu, Shengda
Deng, Shengchao
Yan, Tengfei
Zhang, Xin
Tian, Ruizhen
Xu, Jiayun
Sun, Hongcheng
Yu, Shuangjiang
Liu, Junqiu
author_facet Liu, Shengda
Deng, Shengchao
Yan, Tengfei
Zhang, Xin
Tian, Ruizhen
Xu, Jiayun
Sun, Hongcheng
Yu, Shuangjiang
Liu, Junqiu
author_sort Liu, Shengda
collection PubMed
description Smart hydrogels are typical functional soft materials, but their functional and mechanical properties are compromised upon micro- or macro-mechanical damage. In contrast, hydrogels with self-healing properties overcome this limitation. Herein, a dual dynamic bind, cross-linked, self-healing protein hydrogel is prepared, based on Schiff base bonds and diselenide bonds. The Schiff base bond is a typical dynamic covalent bond and the diselenide bond is an emerging dynamic covalent bond with a visible light response, which gives the resulting hydrogel a dual response in visible light and a desirable self-healing ability. The diselenide-containing protein hydrogels were biocompatible due to the fact that their main component was protein. In addition, the hydrogels loaded with glucose oxidase (GOx) could be transformed into sols in glucose solution due to the sensitive response of the diselenide bonds to the generated hydrogen peroxide (H(2)O(2)) by enzymatic catalysis. This work demonstrated a diselenide-containing protein hydrogel that could efficiently self-heal up to nearly 100% without compromising their mechanical properties under visible light at room temperature.
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spelling pubmed-87079532021-12-25 Biocompatible Diselenide-Containing Protein Hydrogels with Effective Visible-Light-Initiated Self-Healing Properties Liu, Shengda Deng, Shengchao Yan, Tengfei Zhang, Xin Tian, Ruizhen Xu, Jiayun Sun, Hongcheng Yu, Shuangjiang Liu, Junqiu Polymers (Basel) Communication Smart hydrogels are typical functional soft materials, but their functional and mechanical properties are compromised upon micro- or macro-mechanical damage. In contrast, hydrogels with self-healing properties overcome this limitation. Herein, a dual dynamic bind, cross-linked, self-healing protein hydrogel is prepared, based on Schiff base bonds and diselenide bonds. The Schiff base bond is a typical dynamic covalent bond and the diselenide bond is an emerging dynamic covalent bond with a visible light response, which gives the resulting hydrogel a dual response in visible light and a desirable self-healing ability. The diselenide-containing protein hydrogels were biocompatible due to the fact that their main component was protein. In addition, the hydrogels loaded with glucose oxidase (GOx) could be transformed into sols in glucose solution due to the sensitive response of the diselenide bonds to the generated hydrogen peroxide (H(2)O(2)) by enzymatic catalysis. This work demonstrated a diselenide-containing protein hydrogel that could efficiently self-heal up to nearly 100% without compromising their mechanical properties under visible light at room temperature. MDPI 2021-12-13 /pmc/articles/PMC8707953/ /pubmed/34960914 http://dx.doi.org/10.3390/polym13244360 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Liu, Shengda
Deng, Shengchao
Yan, Tengfei
Zhang, Xin
Tian, Ruizhen
Xu, Jiayun
Sun, Hongcheng
Yu, Shuangjiang
Liu, Junqiu
Biocompatible Diselenide-Containing Protein Hydrogels with Effective Visible-Light-Initiated Self-Healing Properties
title Biocompatible Diselenide-Containing Protein Hydrogels with Effective Visible-Light-Initiated Self-Healing Properties
title_full Biocompatible Diselenide-Containing Protein Hydrogels with Effective Visible-Light-Initiated Self-Healing Properties
title_fullStr Biocompatible Diselenide-Containing Protein Hydrogels with Effective Visible-Light-Initiated Self-Healing Properties
title_full_unstemmed Biocompatible Diselenide-Containing Protein Hydrogels with Effective Visible-Light-Initiated Self-Healing Properties
title_short Biocompatible Diselenide-Containing Protein Hydrogels with Effective Visible-Light-Initiated Self-Healing Properties
title_sort biocompatible diselenide-containing protein hydrogels with effective visible-light-initiated self-healing properties
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707953/
https://www.ncbi.nlm.nih.gov/pubmed/34960914
http://dx.doi.org/10.3390/polym13244360
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