Herpetic Keratitis Preceded by COVID-19 Vaccination

The global Coronavirus Disease 2019 (COVID-19) pandemic has accelerated vaccine development at an unprecedented rate. A large population of people have received COVID-19 vaccines, while the vaccine safety data are limited. Here, we reported two cases of herpetic keratitis that occurred soon after re...

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Autores principales: Li, Saiqun, Jia, Xiuhua, Yu, Fei, Wang, Qian, Zhang, Tingting, Yuan, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707988/
https://www.ncbi.nlm.nih.gov/pubmed/34960139
http://dx.doi.org/10.3390/vaccines9121394
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author Li, Saiqun
Jia, Xiuhua
Yu, Fei
Wang, Qian
Zhang, Tingting
Yuan, Jin
author_facet Li, Saiqun
Jia, Xiuhua
Yu, Fei
Wang, Qian
Zhang, Tingting
Yuan, Jin
author_sort Li, Saiqun
collection PubMed
description The global Coronavirus Disease 2019 (COVID-19) pandemic has accelerated vaccine development at an unprecedented rate. A large population of people have received COVID-19 vaccines, while the vaccine safety data are limited. Here, we reported two cases of herpetic keratitis that occurred soon after receiving the inactivated COVID-19 vaccines. Case 1 was a 60-year-old woman who underwent penetrating keratoplasty (PKP) one year ago for corneal scarring caused by herpes simplex keratitis (HSK), and case 2 was a 51-year-old man with an unremarkable medical history. Both patients developed herpetic keratitis (HSK and varicella-zoster virus corneal endotheliitis, respectively) soon after receiving the inactivated COVID-19 vaccines (Sinovac). Herpetic keratitis was treated successfully with topical or plus oral antiviral ganciclovir. The short latency time in these two cases suggested that an inactivated COVID-19 vaccine may have a risk of triggering ocular herpes virus reactivation. Both clinicians and patients should be aware of this phenomenon. However, a causal relationship awaits confirmation.
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spelling pubmed-87079882021-12-25 Herpetic Keratitis Preceded by COVID-19 Vaccination Li, Saiqun Jia, Xiuhua Yu, Fei Wang, Qian Zhang, Tingting Yuan, Jin Vaccines (Basel) Case Report The global Coronavirus Disease 2019 (COVID-19) pandemic has accelerated vaccine development at an unprecedented rate. A large population of people have received COVID-19 vaccines, while the vaccine safety data are limited. Here, we reported two cases of herpetic keratitis that occurred soon after receiving the inactivated COVID-19 vaccines. Case 1 was a 60-year-old woman who underwent penetrating keratoplasty (PKP) one year ago for corneal scarring caused by herpes simplex keratitis (HSK), and case 2 was a 51-year-old man with an unremarkable medical history. Both patients developed herpetic keratitis (HSK and varicella-zoster virus corneal endotheliitis, respectively) soon after receiving the inactivated COVID-19 vaccines (Sinovac). Herpetic keratitis was treated successfully with topical or plus oral antiviral ganciclovir. The short latency time in these two cases suggested that an inactivated COVID-19 vaccine may have a risk of triggering ocular herpes virus reactivation. Both clinicians and patients should be aware of this phenomenon. However, a causal relationship awaits confirmation. MDPI 2021-11-25 /pmc/articles/PMC8707988/ /pubmed/34960139 http://dx.doi.org/10.3390/vaccines9121394 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Li, Saiqun
Jia, Xiuhua
Yu, Fei
Wang, Qian
Zhang, Tingting
Yuan, Jin
Herpetic Keratitis Preceded by COVID-19 Vaccination
title Herpetic Keratitis Preceded by COVID-19 Vaccination
title_full Herpetic Keratitis Preceded by COVID-19 Vaccination
title_fullStr Herpetic Keratitis Preceded by COVID-19 Vaccination
title_full_unstemmed Herpetic Keratitis Preceded by COVID-19 Vaccination
title_short Herpetic Keratitis Preceded by COVID-19 Vaccination
title_sort herpetic keratitis preceded by covid-19 vaccination
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707988/
https://www.ncbi.nlm.nih.gov/pubmed/34960139
http://dx.doi.org/10.3390/vaccines9121394
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