Herpetic Keratitis Preceded by COVID-19 Vaccination
The global Coronavirus Disease 2019 (COVID-19) pandemic has accelerated vaccine development at an unprecedented rate. A large population of people have received COVID-19 vaccines, while the vaccine safety data are limited. Here, we reported two cases of herpetic keratitis that occurred soon after re...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707988/ https://www.ncbi.nlm.nih.gov/pubmed/34960139 http://dx.doi.org/10.3390/vaccines9121394 |
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author | Li, Saiqun Jia, Xiuhua Yu, Fei Wang, Qian Zhang, Tingting Yuan, Jin |
author_facet | Li, Saiqun Jia, Xiuhua Yu, Fei Wang, Qian Zhang, Tingting Yuan, Jin |
author_sort | Li, Saiqun |
collection | PubMed |
description | The global Coronavirus Disease 2019 (COVID-19) pandemic has accelerated vaccine development at an unprecedented rate. A large population of people have received COVID-19 vaccines, while the vaccine safety data are limited. Here, we reported two cases of herpetic keratitis that occurred soon after receiving the inactivated COVID-19 vaccines. Case 1 was a 60-year-old woman who underwent penetrating keratoplasty (PKP) one year ago for corneal scarring caused by herpes simplex keratitis (HSK), and case 2 was a 51-year-old man with an unremarkable medical history. Both patients developed herpetic keratitis (HSK and varicella-zoster virus corneal endotheliitis, respectively) soon after receiving the inactivated COVID-19 vaccines (Sinovac). Herpetic keratitis was treated successfully with topical or plus oral antiviral ganciclovir. The short latency time in these two cases suggested that an inactivated COVID-19 vaccine may have a risk of triggering ocular herpes virus reactivation. Both clinicians and patients should be aware of this phenomenon. However, a causal relationship awaits confirmation. |
format | Online Article Text |
id | pubmed-8707988 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87079882021-12-25 Herpetic Keratitis Preceded by COVID-19 Vaccination Li, Saiqun Jia, Xiuhua Yu, Fei Wang, Qian Zhang, Tingting Yuan, Jin Vaccines (Basel) Case Report The global Coronavirus Disease 2019 (COVID-19) pandemic has accelerated vaccine development at an unprecedented rate. A large population of people have received COVID-19 vaccines, while the vaccine safety data are limited. Here, we reported two cases of herpetic keratitis that occurred soon after receiving the inactivated COVID-19 vaccines. Case 1 was a 60-year-old woman who underwent penetrating keratoplasty (PKP) one year ago for corneal scarring caused by herpes simplex keratitis (HSK), and case 2 was a 51-year-old man with an unremarkable medical history. Both patients developed herpetic keratitis (HSK and varicella-zoster virus corneal endotheliitis, respectively) soon after receiving the inactivated COVID-19 vaccines (Sinovac). Herpetic keratitis was treated successfully with topical or plus oral antiviral ganciclovir. The short latency time in these two cases suggested that an inactivated COVID-19 vaccine may have a risk of triggering ocular herpes virus reactivation. Both clinicians and patients should be aware of this phenomenon. However, a causal relationship awaits confirmation. MDPI 2021-11-25 /pmc/articles/PMC8707988/ /pubmed/34960139 http://dx.doi.org/10.3390/vaccines9121394 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Li, Saiqun Jia, Xiuhua Yu, Fei Wang, Qian Zhang, Tingting Yuan, Jin Herpetic Keratitis Preceded by COVID-19 Vaccination |
title | Herpetic Keratitis Preceded by COVID-19 Vaccination |
title_full | Herpetic Keratitis Preceded by COVID-19 Vaccination |
title_fullStr | Herpetic Keratitis Preceded by COVID-19 Vaccination |
title_full_unstemmed | Herpetic Keratitis Preceded by COVID-19 Vaccination |
title_short | Herpetic Keratitis Preceded by COVID-19 Vaccination |
title_sort | herpetic keratitis preceded by covid-19 vaccination |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707988/ https://www.ncbi.nlm.nih.gov/pubmed/34960139 http://dx.doi.org/10.3390/vaccines9121394 |
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