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Hemorheological Parameters in Diabetic Patients: Role of Glucose Lowering Therapies

Diabetes mellitus influences several important hemorheological parameters including blood viscosity, erythrocyte aggregation and deformability. In the present study, 159 type-2 diabetic patients and 25 healthy controls were involved. Patient’s age, body weight, body mass index (BMI), smoking habits,...

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Autores principales: Biro, Katalin, Feher, Gergely, Vekasi, Judit, Kenyeres, Peter, Toth, Kalman, Koltai, Katalin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708076/
https://www.ncbi.nlm.nih.gov/pubmed/34940563
http://dx.doi.org/10.3390/metabo11120806
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author Biro, Katalin
Feher, Gergely
Vekasi, Judit
Kenyeres, Peter
Toth, Kalman
Koltai, Katalin
author_facet Biro, Katalin
Feher, Gergely
Vekasi, Judit
Kenyeres, Peter
Toth, Kalman
Koltai, Katalin
author_sort Biro, Katalin
collection PubMed
description Diabetes mellitus influences several important hemorheological parameters including blood viscosity, erythrocyte aggregation and deformability. In the present study, 159 type-2 diabetic patients and 25 healthy controls were involved. Patient’s age, body weight, body mass index (BMI), smoking habits, physical activity, history of cardiovascular diseases, current antidiabetic therapy and concomitant medication were recorded. Patients were grouped according to their antidiabetic treatment with insulin, or with one or more of the following antidiabetic drugs: metformin, sulfonylureas, acarbose, or no antidiabetic therapy. Hemorheological measurements (hematocrit, erythrocyte aggregation, plasma fibrinogen, whole blood and plasma viscosity), von Willebrand factor activity, and platelet aggregation measurements were performed. Platelet aggregation was investigated with the method of Born. Plasma viscosity and red blood cell aggregation were significatly higher in diabetes. No significant difference was found in hemorheological parameters between different antidiabetic regimens. Whole blood and plasma viscosity and red blood cell aggregation correlated with glucose levels but not with HbA1C levels. In conclusion, plasma and whole blood viscosity, as well as red blood cell aggregation appear to be associated with concurrent hyperglycemia, but not with the quality of glycemic control or the applied antidiabetic treatment. Platelet aggregation induced by ADP or epinephrine does not seem to be associated with diabetes even at subthreshold doses.
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spelling pubmed-87080762021-12-25 Hemorheological Parameters in Diabetic Patients: Role of Glucose Lowering Therapies Biro, Katalin Feher, Gergely Vekasi, Judit Kenyeres, Peter Toth, Kalman Koltai, Katalin Metabolites Article Diabetes mellitus influences several important hemorheological parameters including blood viscosity, erythrocyte aggregation and deformability. In the present study, 159 type-2 diabetic patients and 25 healthy controls were involved. Patient’s age, body weight, body mass index (BMI), smoking habits, physical activity, history of cardiovascular diseases, current antidiabetic therapy and concomitant medication were recorded. Patients were grouped according to their antidiabetic treatment with insulin, or with one or more of the following antidiabetic drugs: metformin, sulfonylureas, acarbose, or no antidiabetic therapy. Hemorheological measurements (hematocrit, erythrocyte aggregation, plasma fibrinogen, whole blood and plasma viscosity), von Willebrand factor activity, and platelet aggregation measurements were performed. Platelet aggregation was investigated with the method of Born. Plasma viscosity and red blood cell aggregation were significatly higher in diabetes. No significant difference was found in hemorheological parameters between different antidiabetic regimens. Whole blood and plasma viscosity and red blood cell aggregation correlated with glucose levels but not with HbA1C levels. In conclusion, plasma and whole blood viscosity, as well as red blood cell aggregation appear to be associated with concurrent hyperglycemia, but not with the quality of glycemic control or the applied antidiabetic treatment. Platelet aggregation induced by ADP or epinephrine does not seem to be associated with diabetes even at subthreshold doses. MDPI 2021-11-27 /pmc/articles/PMC8708076/ /pubmed/34940563 http://dx.doi.org/10.3390/metabo11120806 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Biro, Katalin
Feher, Gergely
Vekasi, Judit
Kenyeres, Peter
Toth, Kalman
Koltai, Katalin
Hemorheological Parameters in Diabetic Patients: Role of Glucose Lowering Therapies
title Hemorheological Parameters in Diabetic Patients: Role of Glucose Lowering Therapies
title_full Hemorheological Parameters in Diabetic Patients: Role of Glucose Lowering Therapies
title_fullStr Hemorheological Parameters in Diabetic Patients: Role of Glucose Lowering Therapies
title_full_unstemmed Hemorheological Parameters in Diabetic Patients: Role of Glucose Lowering Therapies
title_short Hemorheological Parameters in Diabetic Patients: Role of Glucose Lowering Therapies
title_sort hemorheological parameters in diabetic patients: role of glucose lowering therapies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708076/
https://www.ncbi.nlm.nih.gov/pubmed/34940563
http://dx.doi.org/10.3390/metabo11120806
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