Modern Approaches to Acellular Therapy in Bone and Dental Regeneration

An approach called cell-free therapy has rapidly developed in regenerative medicine over the past decade. Understanding the molecular mechanisms and signaling pathways involved in the internal potential of tissue repair inspires the development of new strategies aimed at controlling and enhancing th...

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Autores principales: Ivanov, Alexey A., Kuznetsova, Alla V., Popova, Olga P., Danilova, Tamara I., Yanushevich, Oleg O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708083/
https://www.ncbi.nlm.nih.gov/pubmed/34948251
http://dx.doi.org/10.3390/ijms222413454
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author Ivanov, Alexey A.
Kuznetsova, Alla V.
Popova, Olga P.
Danilova, Tamara I.
Yanushevich, Oleg O.
author_facet Ivanov, Alexey A.
Kuznetsova, Alla V.
Popova, Olga P.
Danilova, Tamara I.
Yanushevich, Oleg O.
author_sort Ivanov, Alexey A.
collection PubMed
description An approach called cell-free therapy has rapidly developed in regenerative medicine over the past decade. Understanding the molecular mechanisms and signaling pathways involved in the internal potential of tissue repair inspires the development of new strategies aimed at controlling and enhancing these processes during regeneration. The use of stem cell mobilization, or homing for regeneration based on endogenous healing mechanisms, prompted a new concept in regenerative medicine: endogenous regenerative medicine. The application of cell-free therapeutic agents leading to the recruitment/homing of endogenous stem cells has advantages in overcoming the limitations and risks associated with cell therapy. In this review, we discuss the potential of cell-free products such as the decellularized extracellular matrix, growth factors, extracellular vesicles and miRNAs in endogenous bone and dental regeneration.
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spelling pubmed-87080832021-12-25 Modern Approaches to Acellular Therapy in Bone and Dental Regeneration Ivanov, Alexey A. Kuznetsova, Alla V. Popova, Olga P. Danilova, Tamara I. Yanushevich, Oleg O. Int J Mol Sci Review An approach called cell-free therapy has rapidly developed in regenerative medicine over the past decade. Understanding the molecular mechanisms and signaling pathways involved in the internal potential of tissue repair inspires the development of new strategies aimed at controlling and enhancing these processes during regeneration. The use of stem cell mobilization, or homing for regeneration based on endogenous healing mechanisms, prompted a new concept in regenerative medicine: endogenous regenerative medicine. The application of cell-free therapeutic agents leading to the recruitment/homing of endogenous stem cells has advantages in overcoming the limitations and risks associated with cell therapy. In this review, we discuss the potential of cell-free products such as the decellularized extracellular matrix, growth factors, extracellular vesicles and miRNAs in endogenous bone and dental regeneration. MDPI 2021-12-15 /pmc/articles/PMC8708083/ /pubmed/34948251 http://dx.doi.org/10.3390/ijms222413454 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ivanov, Alexey A.
Kuznetsova, Alla V.
Popova, Olga P.
Danilova, Tamara I.
Yanushevich, Oleg O.
Modern Approaches to Acellular Therapy in Bone and Dental Regeneration
title Modern Approaches to Acellular Therapy in Bone and Dental Regeneration
title_full Modern Approaches to Acellular Therapy in Bone and Dental Regeneration
title_fullStr Modern Approaches to Acellular Therapy in Bone and Dental Regeneration
title_full_unstemmed Modern Approaches to Acellular Therapy in Bone and Dental Regeneration
title_short Modern Approaches to Acellular Therapy in Bone and Dental Regeneration
title_sort modern approaches to acellular therapy in bone and dental regeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708083/
https://www.ncbi.nlm.nih.gov/pubmed/34948251
http://dx.doi.org/10.3390/ijms222413454
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