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Extrahypothalamic Control of Energy Balance and Its Connection with Reproduction: Roles of the Amygdala

Body energy and metabolic homeostasis are exquisitely controlled by multiple, often overlapping regulatory mechanisms, which permit the tight adjustment between fuel reserves, internal needs, and environmental (e.g., nutritional) conditions. As such, this function is sensitive to and closely connect...

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Detalles Bibliográficos
Autores principales: Pineda, Rafael, Torres, Encarnacion, Tena-Sempere, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708157/
https://www.ncbi.nlm.nih.gov/pubmed/34940594
http://dx.doi.org/10.3390/metabo11120837
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author Pineda, Rafael
Torres, Encarnacion
Tena-Sempere, Manuel
author_facet Pineda, Rafael
Torres, Encarnacion
Tena-Sempere, Manuel
author_sort Pineda, Rafael
collection PubMed
description Body energy and metabolic homeostasis are exquisitely controlled by multiple, often overlapping regulatory mechanisms, which permit the tight adjustment between fuel reserves, internal needs, and environmental (e.g., nutritional) conditions. As such, this function is sensitive to and closely connected with other relevant bodily systems, including reproduction and gonadal function. The aim of this mini-review article is to summarize the most salient experimental data supporting a role of the amygdala as a key brain region for emotional learning and behavior, including reward processing, in the physiological control of feeding and energy balance. In particular, a major focus will be placed on the putative interplay between reproductive signals and amygdala pathways, as it pertains to the control of metabolism, as complementary, extrahypothalamic circuit for the integral control of energy balance and gonadal function.
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spelling pubmed-87081572021-12-25 Extrahypothalamic Control of Energy Balance and Its Connection with Reproduction: Roles of the Amygdala Pineda, Rafael Torres, Encarnacion Tena-Sempere, Manuel Metabolites Review Body energy and metabolic homeostasis are exquisitely controlled by multiple, often overlapping regulatory mechanisms, which permit the tight adjustment between fuel reserves, internal needs, and environmental (e.g., nutritional) conditions. As such, this function is sensitive to and closely connected with other relevant bodily systems, including reproduction and gonadal function. The aim of this mini-review article is to summarize the most salient experimental data supporting a role of the amygdala as a key brain region for emotional learning and behavior, including reward processing, in the physiological control of feeding and energy balance. In particular, a major focus will be placed on the putative interplay between reproductive signals and amygdala pathways, as it pertains to the control of metabolism, as complementary, extrahypothalamic circuit for the integral control of energy balance and gonadal function. MDPI 2021-12-03 /pmc/articles/PMC8708157/ /pubmed/34940594 http://dx.doi.org/10.3390/metabo11120837 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pineda, Rafael
Torres, Encarnacion
Tena-Sempere, Manuel
Extrahypothalamic Control of Energy Balance and Its Connection with Reproduction: Roles of the Amygdala
title Extrahypothalamic Control of Energy Balance and Its Connection with Reproduction: Roles of the Amygdala
title_full Extrahypothalamic Control of Energy Balance and Its Connection with Reproduction: Roles of the Amygdala
title_fullStr Extrahypothalamic Control of Energy Balance and Its Connection with Reproduction: Roles of the Amygdala
title_full_unstemmed Extrahypothalamic Control of Energy Balance and Its Connection with Reproduction: Roles of the Amygdala
title_short Extrahypothalamic Control of Energy Balance and Its Connection with Reproduction: Roles of the Amygdala
title_sort extrahypothalamic control of energy balance and its connection with reproduction: roles of the amygdala
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708157/
https://www.ncbi.nlm.nih.gov/pubmed/34940594
http://dx.doi.org/10.3390/metabo11120837
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