[(18)F] Sodium Fluoride PET Kinetic Parameters in Bone Imaging

This report describes the significance of the kinetic parameters (k-values) obtained from the analysis of dynamic positron emission tomography (PET) scans using the Hawkins model describing the pharmacokinetics of sodium fluoride ([(18)F]NaF) to understand bone physiology. Dynamic [(18)F]NaF PET sca...

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Detalles Bibliográficos
Autores principales: Puri, Tanuj, Frost, Michelle L., Cook, Gary J., Blake, Glen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708178/
https://www.ncbi.nlm.nih.gov/pubmed/34941643
http://dx.doi.org/10.3390/tomography7040071
Descripción
Sumario:This report describes the significance of the kinetic parameters (k-values) obtained from the analysis of dynamic positron emission tomography (PET) scans using the Hawkins model describing the pharmacokinetics of sodium fluoride ([(18)F]NaF) to understand bone physiology. Dynamic [(18)F]NaF PET scans may be useful as an imaging biomarker in early phase clinical trials of novel drugs in development by permitting early detection of treatment-response signals that may help avoid late-stage attrition.

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