[(18)F] Sodium Fluoride PET Kinetic Parameters in Bone Imaging

This report describes the significance of the kinetic parameters (k-values) obtained from the analysis of dynamic positron emission tomography (PET) scans using the Hawkins model describing the pharmacokinetics of sodium fluoride ([(18)F]NaF) to understand bone physiology. Dynamic [(18)F]NaF PET sca...

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Detalles Bibliográficos
Autores principales: Puri, Tanuj, Frost, Michelle L., Cook, Gary J., Blake, Glen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708178/
https://www.ncbi.nlm.nih.gov/pubmed/34941643
http://dx.doi.org/10.3390/tomography7040071
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author Puri, Tanuj
Frost, Michelle L.
Cook, Gary J.
Blake, Glen M.
author_facet Puri, Tanuj
Frost, Michelle L.
Cook, Gary J.
Blake, Glen M.
author_sort Puri, Tanuj
collection PubMed
description This report describes the significance of the kinetic parameters (k-values) obtained from the analysis of dynamic positron emission tomography (PET) scans using the Hawkins model describing the pharmacokinetics of sodium fluoride ([(18)F]NaF) to understand bone physiology. Dynamic [(18)F]NaF PET scans may be useful as an imaging biomarker in early phase clinical trials of novel drugs in development by permitting early detection of treatment-response signals that may help avoid late-stage attrition.
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spelling pubmed-87081782021-12-25 [(18)F] Sodium Fluoride PET Kinetic Parameters in Bone Imaging Puri, Tanuj Frost, Michelle L. Cook, Gary J. Blake, Glen M. Tomography Review This report describes the significance of the kinetic parameters (k-values) obtained from the analysis of dynamic positron emission tomography (PET) scans using the Hawkins model describing the pharmacokinetics of sodium fluoride ([(18)F]NaF) to understand bone physiology. Dynamic [(18)F]NaF PET scans may be useful as an imaging biomarker in early phase clinical trials of novel drugs in development by permitting early detection of treatment-response signals that may help avoid late-stage attrition. MDPI 2021-12-01 /pmc/articles/PMC8708178/ /pubmed/34941643 http://dx.doi.org/10.3390/tomography7040071 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Puri, Tanuj
Frost, Michelle L.
Cook, Gary J.
Blake, Glen M.
[(18)F] Sodium Fluoride PET Kinetic Parameters in Bone Imaging
title [(18)F] Sodium Fluoride PET Kinetic Parameters in Bone Imaging
title_full [(18)F] Sodium Fluoride PET Kinetic Parameters in Bone Imaging
title_fullStr [(18)F] Sodium Fluoride PET Kinetic Parameters in Bone Imaging
title_full_unstemmed [(18)F] Sodium Fluoride PET Kinetic Parameters in Bone Imaging
title_short [(18)F] Sodium Fluoride PET Kinetic Parameters in Bone Imaging
title_sort [(18)f] sodium fluoride pet kinetic parameters in bone imaging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708178/
https://www.ncbi.nlm.nih.gov/pubmed/34941643
http://dx.doi.org/10.3390/tomography7040071
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AT frostmichellel 18fsodiumfluoridepetkineticparametersinboneimaging
AT cookgaryj 18fsodiumfluoridepetkineticparametersinboneimaging
AT blakeglenm 18fsodiumfluoridepetkineticparametersinboneimaging

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