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Circulating IgG Levels in SARS-CoV-2 Convalescent Individuals in Cyprus

Long-term persistence and the heterogeneity of humoral response to SARS-CoV-2 have not yet been thoroughly investigated. The aim of this work is to study the production of circulating immunoglobulin class G (IgG) antibodies against SARS-CoV-2 in individuals with past infection in Cyprus. Individuals...

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Autores principales: Mamais, Ioannis, Malatras, Apostolos, Papagregoriou, Gregory, Giallourou, Natasa, Kakouri, Andrea C., Karayiannis, Peter, Koliou, Maria, Christaki, Eirini, Nikolopoulos, Georgios K., Deltas, Constantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708243/
https://www.ncbi.nlm.nih.gov/pubmed/34945178
http://dx.doi.org/10.3390/jcm10245882
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author Mamais, Ioannis
Malatras, Apostolos
Papagregoriou, Gregory
Giallourou, Natasa
Kakouri, Andrea C.
Karayiannis, Peter
Koliou, Maria
Christaki, Eirini
Nikolopoulos, Georgios K.
Deltas, Constantinos
author_facet Mamais, Ioannis
Malatras, Apostolos
Papagregoriou, Gregory
Giallourou, Natasa
Kakouri, Andrea C.
Karayiannis, Peter
Koliou, Maria
Christaki, Eirini
Nikolopoulos, Georgios K.
Deltas, Constantinos
author_sort Mamais, Ioannis
collection PubMed
description Long-term persistence and the heterogeneity of humoral response to SARS-CoV-2 have not yet been thoroughly investigated. The aim of this work is to study the production of circulating immunoglobulin class G (IgG) antibodies against SARS-CoV-2 in individuals with past infection in Cyprus. Individuals of the general population, with or without previous SARS-CoV-2 infection, were invited to visit the Biobank at the Center of Excellence in Biobanking and Biomedical Research of the University of Cyprus. Serum IgG antibodies were measured using the SARS-CoV-2 IgG and the SARS-CoV-2 IgG II Quant assays of Abbott Laboratories. Antibody responses to SARS-CoV-2 were also evaluated against participants’ demographic and clinical data. All statistical analyses were conducted in Stata 16. The median levels of receptor binding domain (RBD)-specific IgG in 969 unvaccinated individuals, who were reportedly infected between November 2020 and September 2021, were 432.1 arbitrary units (AI)/mL (interquartile range—IQR: 182.4–1147.3). Higher antibody levels were observed in older participants, males, and those who reportedly developed symptoms or were hospitalized. The RBD-specific IgG levels peaked at three months post symptom onset and subsequently decreased up to month six, with a slower decay thereafter. IgG response to the RBD of SARS-CoV-2 is bi-phasic with considerable titer variability. Levels of IgG are significantly associated with several parameters, including age, gender, and severity of symptoms.
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spelling pubmed-87082432021-12-25 Circulating IgG Levels in SARS-CoV-2 Convalescent Individuals in Cyprus Mamais, Ioannis Malatras, Apostolos Papagregoriou, Gregory Giallourou, Natasa Kakouri, Andrea C. Karayiannis, Peter Koliou, Maria Christaki, Eirini Nikolopoulos, Georgios K. Deltas, Constantinos J Clin Med Article Long-term persistence and the heterogeneity of humoral response to SARS-CoV-2 have not yet been thoroughly investigated. The aim of this work is to study the production of circulating immunoglobulin class G (IgG) antibodies against SARS-CoV-2 in individuals with past infection in Cyprus. Individuals of the general population, with or without previous SARS-CoV-2 infection, were invited to visit the Biobank at the Center of Excellence in Biobanking and Biomedical Research of the University of Cyprus. Serum IgG antibodies were measured using the SARS-CoV-2 IgG and the SARS-CoV-2 IgG II Quant assays of Abbott Laboratories. Antibody responses to SARS-CoV-2 were also evaluated against participants’ demographic and clinical data. All statistical analyses were conducted in Stata 16. The median levels of receptor binding domain (RBD)-specific IgG in 969 unvaccinated individuals, who were reportedly infected between November 2020 and September 2021, were 432.1 arbitrary units (AI)/mL (interquartile range—IQR: 182.4–1147.3). Higher antibody levels were observed in older participants, males, and those who reportedly developed symptoms or were hospitalized. The RBD-specific IgG levels peaked at three months post symptom onset and subsequently decreased up to month six, with a slower decay thereafter. IgG response to the RBD of SARS-CoV-2 is bi-phasic with considerable titer variability. Levels of IgG are significantly associated with several parameters, including age, gender, and severity of symptoms. MDPI 2021-12-15 /pmc/articles/PMC8708243/ /pubmed/34945178 http://dx.doi.org/10.3390/jcm10245882 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mamais, Ioannis
Malatras, Apostolos
Papagregoriou, Gregory
Giallourou, Natasa
Kakouri, Andrea C.
Karayiannis, Peter
Koliou, Maria
Christaki, Eirini
Nikolopoulos, Georgios K.
Deltas, Constantinos
Circulating IgG Levels in SARS-CoV-2 Convalescent Individuals in Cyprus
title Circulating IgG Levels in SARS-CoV-2 Convalescent Individuals in Cyprus
title_full Circulating IgG Levels in SARS-CoV-2 Convalescent Individuals in Cyprus
title_fullStr Circulating IgG Levels in SARS-CoV-2 Convalescent Individuals in Cyprus
title_full_unstemmed Circulating IgG Levels in SARS-CoV-2 Convalescent Individuals in Cyprus
title_short Circulating IgG Levels in SARS-CoV-2 Convalescent Individuals in Cyprus
title_sort circulating igg levels in sars-cov-2 convalescent individuals in cyprus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708243/
https://www.ncbi.nlm.nih.gov/pubmed/34945178
http://dx.doi.org/10.3390/jcm10245882
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