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Circulating IgG Levels in SARS-CoV-2 Convalescent Individuals in Cyprus
Long-term persistence and the heterogeneity of humoral response to SARS-CoV-2 have not yet been thoroughly investigated. The aim of this work is to study the production of circulating immunoglobulin class G (IgG) antibodies against SARS-CoV-2 in individuals with past infection in Cyprus. Individuals...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708243/ https://www.ncbi.nlm.nih.gov/pubmed/34945178 http://dx.doi.org/10.3390/jcm10245882 |
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author | Mamais, Ioannis Malatras, Apostolos Papagregoriou, Gregory Giallourou, Natasa Kakouri, Andrea C. Karayiannis, Peter Koliou, Maria Christaki, Eirini Nikolopoulos, Georgios K. Deltas, Constantinos |
author_facet | Mamais, Ioannis Malatras, Apostolos Papagregoriou, Gregory Giallourou, Natasa Kakouri, Andrea C. Karayiannis, Peter Koliou, Maria Christaki, Eirini Nikolopoulos, Georgios K. Deltas, Constantinos |
author_sort | Mamais, Ioannis |
collection | PubMed |
description | Long-term persistence and the heterogeneity of humoral response to SARS-CoV-2 have not yet been thoroughly investigated. The aim of this work is to study the production of circulating immunoglobulin class G (IgG) antibodies against SARS-CoV-2 in individuals with past infection in Cyprus. Individuals of the general population, with or without previous SARS-CoV-2 infection, were invited to visit the Biobank at the Center of Excellence in Biobanking and Biomedical Research of the University of Cyprus. Serum IgG antibodies were measured using the SARS-CoV-2 IgG and the SARS-CoV-2 IgG II Quant assays of Abbott Laboratories. Antibody responses to SARS-CoV-2 were also evaluated against participants’ demographic and clinical data. All statistical analyses were conducted in Stata 16. The median levels of receptor binding domain (RBD)-specific IgG in 969 unvaccinated individuals, who were reportedly infected between November 2020 and September 2021, were 432.1 arbitrary units (AI)/mL (interquartile range—IQR: 182.4–1147.3). Higher antibody levels were observed in older participants, males, and those who reportedly developed symptoms or were hospitalized. The RBD-specific IgG levels peaked at three months post symptom onset and subsequently decreased up to month six, with a slower decay thereafter. IgG response to the RBD of SARS-CoV-2 is bi-phasic with considerable titer variability. Levels of IgG are significantly associated with several parameters, including age, gender, and severity of symptoms. |
format | Online Article Text |
id | pubmed-8708243 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87082432021-12-25 Circulating IgG Levels in SARS-CoV-2 Convalescent Individuals in Cyprus Mamais, Ioannis Malatras, Apostolos Papagregoriou, Gregory Giallourou, Natasa Kakouri, Andrea C. Karayiannis, Peter Koliou, Maria Christaki, Eirini Nikolopoulos, Georgios K. Deltas, Constantinos J Clin Med Article Long-term persistence and the heterogeneity of humoral response to SARS-CoV-2 have not yet been thoroughly investigated. The aim of this work is to study the production of circulating immunoglobulin class G (IgG) antibodies against SARS-CoV-2 in individuals with past infection in Cyprus. Individuals of the general population, with or without previous SARS-CoV-2 infection, were invited to visit the Biobank at the Center of Excellence in Biobanking and Biomedical Research of the University of Cyprus. Serum IgG antibodies were measured using the SARS-CoV-2 IgG and the SARS-CoV-2 IgG II Quant assays of Abbott Laboratories. Antibody responses to SARS-CoV-2 were also evaluated against participants’ demographic and clinical data. All statistical analyses were conducted in Stata 16. The median levels of receptor binding domain (RBD)-specific IgG in 969 unvaccinated individuals, who were reportedly infected between November 2020 and September 2021, were 432.1 arbitrary units (AI)/mL (interquartile range—IQR: 182.4–1147.3). Higher antibody levels were observed in older participants, males, and those who reportedly developed symptoms or were hospitalized. The RBD-specific IgG levels peaked at three months post symptom onset and subsequently decreased up to month six, with a slower decay thereafter. IgG response to the RBD of SARS-CoV-2 is bi-phasic with considerable titer variability. Levels of IgG are significantly associated with several parameters, including age, gender, and severity of symptoms. MDPI 2021-12-15 /pmc/articles/PMC8708243/ /pubmed/34945178 http://dx.doi.org/10.3390/jcm10245882 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mamais, Ioannis Malatras, Apostolos Papagregoriou, Gregory Giallourou, Natasa Kakouri, Andrea C. Karayiannis, Peter Koliou, Maria Christaki, Eirini Nikolopoulos, Georgios K. Deltas, Constantinos Circulating IgG Levels in SARS-CoV-2 Convalescent Individuals in Cyprus |
title | Circulating IgG Levels in SARS-CoV-2 Convalescent Individuals in Cyprus |
title_full | Circulating IgG Levels in SARS-CoV-2 Convalescent Individuals in Cyprus |
title_fullStr | Circulating IgG Levels in SARS-CoV-2 Convalescent Individuals in Cyprus |
title_full_unstemmed | Circulating IgG Levels in SARS-CoV-2 Convalescent Individuals in Cyprus |
title_short | Circulating IgG Levels in SARS-CoV-2 Convalescent Individuals in Cyprus |
title_sort | circulating igg levels in sars-cov-2 convalescent individuals in cyprus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708243/ https://www.ncbi.nlm.nih.gov/pubmed/34945178 http://dx.doi.org/10.3390/jcm10245882 |
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