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Recent Discoveries in Epigenetic Modifications of Polycystic Kidney Disease

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a heritable renal disease that results in end-stage kidney disease, due to the uncontrolled bilateral growth of cysts throughout the kidneys. While it is known that a mutation within a PKD-causing gene is required for the development of ADPKD,...

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Autores principales: Bowden, Sarah A., Rodger, Euan J., Chatterjee, Aniruddha, Eccles, Michael R., Stayner, Cherie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708269/
https://www.ncbi.nlm.nih.gov/pubmed/34948126
http://dx.doi.org/10.3390/ijms222413327
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author Bowden, Sarah A.
Rodger, Euan J.
Chatterjee, Aniruddha
Eccles, Michael R.
Stayner, Cherie
author_facet Bowden, Sarah A.
Rodger, Euan J.
Chatterjee, Aniruddha
Eccles, Michael R.
Stayner, Cherie
author_sort Bowden, Sarah A.
collection PubMed
description Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a heritable renal disease that results in end-stage kidney disease, due to the uncontrolled bilateral growth of cysts throughout the kidneys. While it is known that a mutation within a PKD-causing gene is required for the development of ADPKD, the underlying mechanism(s) causing cystogenesis and progression of the disease are not well understood. Limited therapeutic options are currently available to slow the rate of cystic growth. Epigenetic modifications, including DNA methylation, are known to be altered in neoplasia, and several FDA-approved therapeutics target these disease-specific changes. As there are many similarities between ADPKD and neoplasia, we (and others) have postulated that ADPKD kidneys contain alterations to their epigenetic landscape that could be exploited for future therapeutic discovery. Here we summarise the current understanding of epigenetic changes that are associated with ADPKD, with a particular focus on the burgeoning field of ADPKD-specific alterations in DNA methylation.
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spelling pubmed-87082692021-12-25 Recent Discoveries in Epigenetic Modifications of Polycystic Kidney Disease Bowden, Sarah A. Rodger, Euan J. Chatterjee, Aniruddha Eccles, Michael R. Stayner, Cherie Int J Mol Sci Review Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a heritable renal disease that results in end-stage kidney disease, due to the uncontrolled bilateral growth of cysts throughout the kidneys. While it is known that a mutation within a PKD-causing gene is required for the development of ADPKD, the underlying mechanism(s) causing cystogenesis and progression of the disease are not well understood. Limited therapeutic options are currently available to slow the rate of cystic growth. Epigenetic modifications, including DNA methylation, are known to be altered in neoplasia, and several FDA-approved therapeutics target these disease-specific changes. As there are many similarities between ADPKD and neoplasia, we (and others) have postulated that ADPKD kidneys contain alterations to their epigenetic landscape that could be exploited for future therapeutic discovery. Here we summarise the current understanding of epigenetic changes that are associated with ADPKD, with a particular focus on the burgeoning field of ADPKD-specific alterations in DNA methylation. MDPI 2021-12-11 /pmc/articles/PMC8708269/ /pubmed/34948126 http://dx.doi.org/10.3390/ijms222413327 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bowden, Sarah A.
Rodger, Euan J.
Chatterjee, Aniruddha
Eccles, Michael R.
Stayner, Cherie
Recent Discoveries in Epigenetic Modifications of Polycystic Kidney Disease
title Recent Discoveries in Epigenetic Modifications of Polycystic Kidney Disease
title_full Recent Discoveries in Epigenetic Modifications of Polycystic Kidney Disease
title_fullStr Recent Discoveries in Epigenetic Modifications of Polycystic Kidney Disease
title_full_unstemmed Recent Discoveries in Epigenetic Modifications of Polycystic Kidney Disease
title_short Recent Discoveries in Epigenetic Modifications of Polycystic Kidney Disease
title_sort recent discoveries in epigenetic modifications of polycystic kidney disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708269/
https://www.ncbi.nlm.nih.gov/pubmed/34948126
http://dx.doi.org/10.3390/ijms222413327
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