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Changes in Salivary Parameters of Oral Immunity after Biologic Therapy for Inflammatory Bowel Disease
We previously observed that inflammatory bowel disease (IBD) may compromise oral host defense, as assessed by decreased salivary levels of immunoglobulin A (IgA) and myeloperoxidase (MPO). Biologic therapy with inhibitors of cytokines or adhesion molecules is increasingly used for patients with IBD....
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708388/ https://www.ncbi.nlm.nih.gov/pubmed/34947940 http://dx.doi.org/10.3390/life11121409 |
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author | Nijakowski, Kacper Rutkowski, Rafał Eder, Piotr Korybalska, Katarzyna Witowski, Janusz Surdacka, Anna |
author_facet | Nijakowski, Kacper Rutkowski, Rafał Eder, Piotr Korybalska, Katarzyna Witowski, Janusz Surdacka, Anna |
author_sort | Nijakowski, Kacper |
collection | PubMed |
description | We previously observed that inflammatory bowel disease (IBD) may compromise oral host defense, as assessed by decreased salivary levels of immunoglobulin A (IgA) and myeloperoxidase (MPO). Biologic therapy with inhibitors of cytokines or adhesion molecules is increasingly used for patients with IBD. Little is known, however, about how this treatment modality affects the release and properties of saliva. Here, we aimed to determine how biologic therapy in patients who had not responded to previous standard treatment with conventional drugs affected the salivary concentration of IgA and MPO. To this end, unstimulated whole mixed saliva was collected before treatment or after 10–12 weeks of therapy from 27 patients with Crohn’s disease (CD) and 24 patients with ulcerative colitis (UC). After the induction phase of therapy with biologics, salivary levels of IgA and MPO increased significantly in UC, but not in CD patients. These increases were approximately 8-fold and 6-fold, for IgA and MPO, respectively. Moreover, these effects occurred in UC patients who responded successfully to therapy, but not in those who failed to improve. Furthermore, the relative increases in salivary IgA and MPO correlated with the relative decrease in UC severity, as assessed by the Mayo scale. These data indicate that the successful therapy with biologics in UC patients results also in improved oral host defense. However, it remains to be determined why such an effect does not occur during therapy for CD. |
format | Online Article Text |
id | pubmed-8708388 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87083882021-12-25 Changes in Salivary Parameters of Oral Immunity after Biologic Therapy for Inflammatory Bowel Disease Nijakowski, Kacper Rutkowski, Rafał Eder, Piotr Korybalska, Katarzyna Witowski, Janusz Surdacka, Anna Life (Basel) Article We previously observed that inflammatory bowel disease (IBD) may compromise oral host defense, as assessed by decreased salivary levels of immunoglobulin A (IgA) and myeloperoxidase (MPO). Biologic therapy with inhibitors of cytokines or adhesion molecules is increasingly used for patients with IBD. Little is known, however, about how this treatment modality affects the release and properties of saliva. Here, we aimed to determine how biologic therapy in patients who had not responded to previous standard treatment with conventional drugs affected the salivary concentration of IgA and MPO. To this end, unstimulated whole mixed saliva was collected before treatment or after 10–12 weeks of therapy from 27 patients with Crohn’s disease (CD) and 24 patients with ulcerative colitis (UC). After the induction phase of therapy with biologics, salivary levels of IgA and MPO increased significantly in UC, but not in CD patients. These increases were approximately 8-fold and 6-fold, for IgA and MPO, respectively. Moreover, these effects occurred in UC patients who responded successfully to therapy, but not in those who failed to improve. Furthermore, the relative increases in salivary IgA and MPO correlated with the relative decrease in UC severity, as assessed by the Mayo scale. These data indicate that the successful therapy with biologics in UC patients results also in improved oral host defense. However, it remains to be determined why such an effect does not occur during therapy for CD. MDPI 2021-12-16 /pmc/articles/PMC8708388/ /pubmed/34947940 http://dx.doi.org/10.3390/life11121409 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Nijakowski, Kacper Rutkowski, Rafał Eder, Piotr Korybalska, Katarzyna Witowski, Janusz Surdacka, Anna Changes in Salivary Parameters of Oral Immunity after Biologic Therapy for Inflammatory Bowel Disease |
title | Changes in Salivary Parameters of Oral Immunity after Biologic Therapy for Inflammatory Bowel Disease |
title_full | Changes in Salivary Parameters of Oral Immunity after Biologic Therapy for Inflammatory Bowel Disease |
title_fullStr | Changes in Salivary Parameters of Oral Immunity after Biologic Therapy for Inflammatory Bowel Disease |
title_full_unstemmed | Changes in Salivary Parameters of Oral Immunity after Biologic Therapy for Inflammatory Bowel Disease |
title_short | Changes in Salivary Parameters of Oral Immunity after Biologic Therapy for Inflammatory Bowel Disease |
title_sort | changes in salivary parameters of oral immunity after biologic therapy for inflammatory bowel disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708388/ https://www.ncbi.nlm.nih.gov/pubmed/34947940 http://dx.doi.org/10.3390/life11121409 |
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