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Sex Differences in Salmonellosis Incidence Rates—An Eight-Country National Data-Pooled Analysis

Background: There are few studies on sex differences in the incidence rates (IR) for salmonellosis over several countries by age and time period. The purpose of this study was to explore the extent and consistency of the sex and age-specific differences. Methods: We analyzed national data from eight...

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Autores principales: Peer, Victoria, Schwartz, Naama, Green, Manfred S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708425/
https://www.ncbi.nlm.nih.gov/pubmed/34945061
http://dx.doi.org/10.3390/jcm10245767
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author Peer, Victoria
Schwartz, Naama
Green, Manfred S.
author_facet Peer, Victoria
Schwartz, Naama
Green, Manfred S.
author_sort Peer, Victoria
collection PubMed
description Background: There are few studies on sex differences in the incidence rates (IR) for salmonellosis over several countries by age and time period. The purpose of this study was to explore the extent and consistency of the sex and age-specific differences. Methods: We analyzed national data from eight countries between 1994 and 2016. We computed country-specific male to female incidence rate ratios (IRRs) for each age group and pooled the data using meta-analytic methods. Variations of the IRRs by age, country and time period were evaluated using meta-regression. Results: The pooled male to female incidence RRs for ages 0–1, 1–4, 5–9 and 10–14, were 1.04 (1.02–1.06), 1.02 (1.01–1.03), 1.07 (1.05–1.08) and 1.28 (1.23–1.33), respectively. For the ages 15–44 and 45–64, the incidence rates were significantly higher in females. Meta-regression analyses indicate that age groups contributed most of the variation in the male to female IRRs. Conclusions: We suggest that genetic and hormonal factors and interactions between hormones and gut microbiota could contribute to the sex differences observed in young children. These findings should provide clues about the mechanisms of the infection, and should be useful in targeting treatments and development of vaccines. Highlights: (1) This manuscript provides consistent estimates of the excess salmonellosis incidence rates in male children up to age 15, which suggests an impact of sex hormones or genetic differences. (2) Our findings should promote the further investigations on sex-related determinants of infectious diseases.
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spelling pubmed-87084252021-12-25 Sex Differences in Salmonellosis Incidence Rates—An Eight-Country National Data-Pooled Analysis Peer, Victoria Schwartz, Naama Green, Manfred S. J Clin Med Article Background: There are few studies on sex differences in the incidence rates (IR) for salmonellosis over several countries by age and time period. The purpose of this study was to explore the extent and consistency of the sex and age-specific differences. Methods: We analyzed national data from eight countries between 1994 and 2016. We computed country-specific male to female incidence rate ratios (IRRs) for each age group and pooled the data using meta-analytic methods. Variations of the IRRs by age, country and time period were evaluated using meta-regression. Results: The pooled male to female incidence RRs for ages 0–1, 1–4, 5–9 and 10–14, were 1.04 (1.02–1.06), 1.02 (1.01–1.03), 1.07 (1.05–1.08) and 1.28 (1.23–1.33), respectively. For the ages 15–44 and 45–64, the incidence rates were significantly higher in females. Meta-regression analyses indicate that age groups contributed most of the variation in the male to female IRRs. Conclusions: We suggest that genetic and hormonal factors and interactions between hormones and gut microbiota could contribute to the sex differences observed in young children. These findings should provide clues about the mechanisms of the infection, and should be useful in targeting treatments and development of vaccines. Highlights: (1) This manuscript provides consistent estimates of the excess salmonellosis incidence rates in male children up to age 15, which suggests an impact of sex hormones or genetic differences. (2) Our findings should promote the further investigations on sex-related determinants of infectious diseases. MDPI 2021-12-09 /pmc/articles/PMC8708425/ /pubmed/34945061 http://dx.doi.org/10.3390/jcm10245767 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Peer, Victoria
Schwartz, Naama
Green, Manfred S.
Sex Differences in Salmonellosis Incidence Rates—An Eight-Country National Data-Pooled Analysis
title Sex Differences in Salmonellosis Incidence Rates—An Eight-Country National Data-Pooled Analysis
title_full Sex Differences in Salmonellosis Incidence Rates—An Eight-Country National Data-Pooled Analysis
title_fullStr Sex Differences in Salmonellosis Incidence Rates—An Eight-Country National Data-Pooled Analysis
title_full_unstemmed Sex Differences in Salmonellosis Incidence Rates—An Eight-Country National Data-Pooled Analysis
title_short Sex Differences in Salmonellosis Incidence Rates—An Eight-Country National Data-Pooled Analysis
title_sort sex differences in salmonellosis incidence rates—an eight-country national data-pooled analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708425/
https://www.ncbi.nlm.nih.gov/pubmed/34945061
http://dx.doi.org/10.3390/jcm10245767
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