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Silica Hydride: A Separation Material Every Analyst Should Know About
This review describes the development, special features and applications of silica hydride-based stationary phases for HPLC. The unique surface of this material is in contrast to ordinary, standard silica, which is the material most frequently used in modern HPLC stationary phases. The standard sili...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708426/ https://www.ncbi.nlm.nih.gov/pubmed/34946587 http://dx.doi.org/10.3390/molecules26247505 |
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author | Pesek, Joseph J. Matyska, Maria T. |
author_facet | Pesek, Joseph J. Matyska, Maria T. |
author_sort | Pesek, Joseph J. |
collection | PubMed |
description | This review describes the development, special features and applications of silica hydride-based stationary phases for HPLC. The unique surface of this material is in contrast to ordinary, standard silica, which is the material most frequently used in modern HPLC stationary phases. The standard silica surface contains mainly silanol (Si-OH) groups, while the silica hydride surface is instead composed of silicon-hydrogen groups, which is much more stable, less reactive and delivers different chromatographic and chemical characteristics. Other aspects of this material are described for each of the different bonded moieties available commercially. Some applications for each of these column types are also presented as well as a generic model for method development on silica hydride-based stationary phases. |
format | Online Article Text |
id | pubmed-8708426 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87084262021-12-25 Silica Hydride: A Separation Material Every Analyst Should Know About Pesek, Joseph J. Matyska, Maria T. Molecules Review This review describes the development, special features and applications of silica hydride-based stationary phases for HPLC. The unique surface of this material is in contrast to ordinary, standard silica, which is the material most frequently used in modern HPLC stationary phases. The standard silica surface contains mainly silanol (Si-OH) groups, while the silica hydride surface is instead composed of silicon-hydrogen groups, which is much more stable, less reactive and delivers different chromatographic and chemical characteristics. Other aspects of this material are described for each of the different bonded moieties available commercially. Some applications for each of these column types are also presented as well as a generic model for method development on silica hydride-based stationary phases. MDPI 2021-12-11 /pmc/articles/PMC8708426/ /pubmed/34946587 http://dx.doi.org/10.3390/molecules26247505 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pesek, Joseph J. Matyska, Maria T. Silica Hydride: A Separation Material Every Analyst Should Know About |
title | Silica Hydride: A Separation Material Every Analyst Should Know About |
title_full | Silica Hydride: A Separation Material Every Analyst Should Know About |
title_fullStr | Silica Hydride: A Separation Material Every Analyst Should Know About |
title_full_unstemmed | Silica Hydride: A Separation Material Every Analyst Should Know About |
title_short | Silica Hydride: A Separation Material Every Analyst Should Know About |
title_sort | silica hydride: a separation material every analyst should know about |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708426/ https://www.ncbi.nlm.nih.gov/pubmed/34946587 http://dx.doi.org/10.3390/molecules26247505 |
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