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MOBP rs616147 Polymorphism and Risk of Amyotrophic Lateral Sclerosis in a Greek Population: A Case-Control Study

Background and Objectives: To date, only one study has investigated the association between the rs616147 polymorphism of the Myelin-associated Oligodendrocyte Basic Protein (MOBP) locus and Amyotrophic Lateral Sclerosis (ALS). Materials and Methods: A case-control study was performed. Patients with...

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Autores principales: Liampas, Ioannis, Siokas, Vasileios, Aloizou, Athina-Maria, Bakirtzis, Christos, Tsouris, Zisis, Nousia, Anastasia, Nasios, Grigorios, Papadimitriou, Dimitra, Liakos, Panagiotis, Bogdanos, Dimitrios P., Hadjigeorgiou, Georgios M., Dardiotis, Efthimios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708438/
https://www.ncbi.nlm.nih.gov/pubmed/34946282
http://dx.doi.org/10.3390/medicina57121337
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author Liampas, Ioannis
Siokas, Vasileios
Aloizou, Athina-Maria
Bakirtzis, Christos
Tsouris, Zisis
Nousia, Anastasia
Nasios, Grigorios
Papadimitriou, Dimitra
Liakos, Panagiotis
Bogdanos, Dimitrios P.
Hadjigeorgiou, Georgios M.
Dardiotis, Efthimios
author_facet Liampas, Ioannis
Siokas, Vasileios
Aloizou, Athina-Maria
Bakirtzis, Christos
Tsouris, Zisis
Nousia, Anastasia
Nasios, Grigorios
Papadimitriou, Dimitra
Liakos, Panagiotis
Bogdanos, Dimitrios P.
Hadjigeorgiou, Georgios M.
Dardiotis, Efthimios
author_sort Liampas, Ioannis
collection PubMed
description Background and Objectives: To date, only one study has investigated the association between the rs616147 polymorphism of the Myelin-associated Oligodendrocyte Basic Protein (MOBP) locus and Amyotrophic Lateral Sclerosis (ALS). Materials and Methods: A case-control study was performed. Patients with definite sporadic ALS were prospectively and consecutively recruited from the inpatient and outpatient clinics of the Neurology Department of the General University Hospital of Larissa, Central Greece. Community based, age and sex matched healthy individuals with a free personal and family history constituted the control group. Results: A total of 155 patients with definite sporadic ALS and an equal number of healthy controls were genotyped. The power of our sample size was slightly above 80% and MOBP rs616147 was determined to be in Hardy-Weinberg Equilibrium among healthy participants (p = 1.00). According to the univariate analysis, there was no significant relationship between rs616147 and ALS [log-additive OR = 0.85 (0.61, 1.19), over-dominant OR = 0.73 (0.46, 1.15), recessive OR = 1.02 (0.50, 2.09), dominant OR = 0.74 (0.47, 1.16), co-dominant OR(1) = 0.71 (0.44, 1.14) and co-dominant OR(2) = 0.88 (0.42, 1.84). Additionally, the effect of rs616147 on the age of ALS onset was determined insignificant using both unadjusted and adjusted (sex, site of onset) cox-proportional models. Finally, rs616147 was not related to the site of ALS onset. Conclusions: Our study is the first to report the absence of an association between MOBP rs616147 and ALS among individuals of Greek ancestry. Additional, larger nationwide and multi-ethnic studies are warranted to shed light on the connection between rs616147 and ALS.
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spelling pubmed-87084382021-12-25 MOBP rs616147 Polymorphism and Risk of Amyotrophic Lateral Sclerosis in a Greek Population: A Case-Control Study Liampas, Ioannis Siokas, Vasileios Aloizou, Athina-Maria Bakirtzis, Christos Tsouris, Zisis Nousia, Anastasia Nasios, Grigorios Papadimitriou, Dimitra Liakos, Panagiotis Bogdanos, Dimitrios P. Hadjigeorgiou, Georgios M. Dardiotis, Efthimios Medicina (Kaunas) Article Background and Objectives: To date, only one study has investigated the association between the rs616147 polymorphism of the Myelin-associated Oligodendrocyte Basic Protein (MOBP) locus and Amyotrophic Lateral Sclerosis (ALS). Materials and Methods: A case-control study was performed. Patients with definite sporadic ALS were prospectively and consecutively recruited from the inpatient and outpatient clinics of the Neurology Department of the General University Hospital of Larissa, Central Greece. Community based, age and sex matched healthy individuals with a free personal and family history constituted the control group. Results: A total of 155 patients with definite sporadic ALS and an equal number of healthy controls were genotyped. The power of our sample size was slightly above 80% and MOBP rs616147 was determined to be in Hardy-Weinberg Equilibrium among healthy participants (p = 1.00). According to the univariate analysis, there was no significant relationship between rs616147 and ALS [log-additive OR = 0.85 (0.61, 1.19), over-dominant OR = 0.73 (0.46, 1.15), recessive OR = 1.02 (0.50, 2.09), dominant OR = 0.74 (0.47, 1.16), co-dominant OR(1) = 0.71 (0.44, 1.14) and co-dominant OR(2) = 0.88 (0.42, 1.84). Additionally, the effect of rs616147 on the age of ALS onset was determined insignificant using both unadjusted and adjusted (sex, site of onset) cox-proportional models. Finally, rs616147 was not related to the site of ALS onset. Conclusions: Our study is the first to report the absence of an association between MOBP rs616147 and ALS among individuals of Greek ancestry. Additional, larger nationwide and multi-ethnic studies are warranted to shed light on the connection between rs616147 and ALS. MDPI 2021-12-07 /pmc/articles/PMC8708438/ /pubmed/34946282 http://dx.doi.org/10.3390/medicina57121337 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liampas, Ioannis
Siokas, Vasileios
Aloizou, Athina-Maria
Bakirtzis, Christos
Tsouris, Zisis
Nousia, Anastasia
Nasios, Grigorios
Papadimitriou, Dimitra
Liakos, Panagiotis
Bogdanos, Dimitrios P.
Hadjigeorgiou, Georgios M.
Dardiotis, Efthimios
MOBP rs616147 Polymorphism and Risk of Amyotrophic Lateral Sclerosis in a Greek Population: A Case-Control Study
title MOBP rs616147 Polymorphism and Risk of Amyotrophic Lateral Sclerosis in a Greek Population: A Case-Control Study
title_full MOBP rs616147 Polymorphism and Risk of Amyotrophic Lateral Sclerosis in a Greek Population: A Case-Control Study
title_fullStr MOBP rs616147 Polymorphism and Risk of Amyotrophic Lateral Sclerosis in a Greek Population: A Case-Control Study
title_full_unstemmed MOBP rs616147 Polymorphism and Risk of Amyotrophic Lateral Sclerosis in a Greek Population: A Case-Control Study
title_short MOBP rs616147 Polymorphism and Risk of Amyotrophic Lateral Sclerosis in a Greek Population: A Case-Control Study
title_sort mobp rs616147 polymorphism and risk of amyotrophic lateral sclerosis in a greek population: a case-control study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708438/
https://www.ncbi.nlm.nih.gov/pubmed/34946282
http://dx.doi.org/10.3390/medicina57121337
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