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Increase of Myocardial Ischemia Time and Short-Term Prognosis of Patients with Acute Myocardial Infarction during the First COVID-19 Pandemic Wave
Background and objectives: early reports showed a decrease in admission rates and an increase in mortality of patients with acute myocardial infarction (AMI) during the first wave of COVID-19 pandemic. We sought to investigate whether the COVID-19 pandemic and associated lockdown had an impact on th...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708571/ https://www.ncbi.nlm.nih.gov/pubmed/34946241 http://dx.doi.org/10.3390/medicina57121296 |
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author | Budrys, Povilas Lizaitis, Mindaugas Cerlinskaite-Bajore, Kamile Bajoras, Vilhelmas Rodevic, Greta Martinonyte, Aurelija Dieckus, Laurynas Badaras, Ignas Serpytis, Pranas Gurevicius, Romualdas Visinskiene, Rasa Buivydas, Romualdas Volodko, Aleksandr Urbonaite, Egle Celutkiene, Jelena Davidavicius, Giedrius |
author_facet | Budrys, Povilas Lizaitis, Mindaugas Cerlinskaite-Bajore, Kamile Bajoras, Vilhelmas Rodevic, Greta Martinonyte, Aurelija Dieckus, Laurynas Badaras, Ignas Serpytis, Pranas Gurevicius, Romualdas Visinskiene, Rasa Buivydas, Romualdas Volodko, Aleksandr Urbonaite, Egle Celutkiene, Jelena Davidavicius, Giedrius |
author_sort | Budrys, Povilas |
collection | PubMed |
description | Background and objectives: early reports showed a decrease in admission rates and an increase in mortality of patients with acute myocardial infarction (AMI) during the first wave of COVID-19 pandemic. We sought to investigate whether the COVID-19 pandemic and associated lockdown had an impact on the ischemia time and prognosis of patients suffering from AMI in the settings of low COVID-19 burden. Materials and Methods: we conducted a retrospective data analysis from a tertiary center in Lithuania of 818 patients with AMI. Data were collected from 1 March to 30 June in 2020 during the peri-lockdown period (2020 group; n = 278) and compared to the same period last year (2019 group; n = 326). The primary study endpoint was all-cause mortality during 3 months of follow-up. Secondary endpoints were heart failure severity (Killip class) on admission and ischemia time in patients with acute ST segment elevation myocardial infarction (STEMI). Results: there was a reduction of 14.7% in admission rate for acute myocardial infarction (AMI) during the peri-lockdown period. The 3-month mortality rate did not differ significantly (6.9% in 2020 vs. 10.5% in 2019, p = 0.341 for STEMI patients; 5.3% in 2020 vs. 2.6% in 2019, p = 0.374 for patients with acute myocardial infarction without ST segment elevation (NSTEMI)). More STEMI patients presented with Killip IV class in 2019 (13.5% vs. 5.5%, p = 0.043, respectively). There was an increase of door-to-PCI time (54.0 [42.0–86.0] in 2019; 63.5 [48.3–97.5] in 2020, p = 0.018) and first medical contact (FMC)-to-PCI time (101.0 [82.5–120.8] in 2019; 115 [97.0–154.5] in 2020, p = 0.01) during the pandemic period. Conclusions: There was a 14.7% reduction of admissions for AMI during the first wave of COVID-19. FMC-to-PCI time increased during the peri-lockdown period, however, it did not translate into worse survival during follow-up. |
format | Online Article Text |
id | pubmed-8708571 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87085712021-12-25 Increase of Myocardial Ischemia Time and Short-Term Prognosis of Patients with Acute Myocardial Infarction during the First COVID-19 Pandemic Wave Budrys, Povilas Lizaitis, Mindaugas Cerlinskaite-Bajore, Kamile Bajoras, Vilhelmas Rodevic, Greta Martinonyte, Aurelija Dieckus, Laurynas Badaras, Ignas Serpytis, Pranas Gurevicius, Romualdas Visinskiene, Rasa Buivydas, Romualdas Volodko, Aleksandr Urbonaite, Egle Celutkiene, Jelena Davidavicius, Giedrius Medicina (Kaunas) Article Background and objectives: early reports showed a decrease in admission rates and an increase in mortality of patients with acute myocardial infarction (AMI) during the first wave of COVID-19 pandemic. We sought to investigate whether the COVID-19 pandemic and associated lockdown had an impact on the ischemia time and prognosis of patients suffering from AMI in the settings of low COVID-19 burden. Materials and Methods: we conducted a retrospective data analysis from a tertiary center in Lithuania of 818 patients with AMI. Data were collected from 1 March to 30 June in 2020 during the peri-lockdown period (2020 group; n = 278) and compared to the same period last year (2019 group; n = 326). The primary study endpoint was all-cause mortality during 3 months of follow-up. Secondary endpoints were heart failure severity (Killip class) on admission and ischemia time in patients with acute ST segment elevation myocardial infarction (STEMI). Results: there was a reduction of 14.7% in admission rate for acute myocardial infarction (AMI) during the peri-lockdown period. The 3-month mortality rate did not differ significantly (6.9% in 2020 vs. 10.5% in 2019, p = 0.341 for STEMI patients; 5.3% in 2020 vs. 2.6% in 2019, p = 0.374 for patients with acute myocardial infarction without ST segment elevation (NSTEMI)). More STEMI patients presented with Killip IV class in 2019 (13.5% vs. 5.5%, p = 0.043, respectively). There was an increase of door-to-PCI time (54.0 [42.0–86.0] in 2019; 63.5 [48.3–97.5] in 2020, p = 0.018) and first medical contact (FMC)-to-PCI time (101.0 [82.5–120.8] in 2019; 115 [97.0–154.5] in 2020, p = 0.01) during the pandemic period. Conclusions: There was a 14.7% reduction of admissions for AMI during the first wave of COVID-19. FMC-to-PCI time increased during the peri-lockdown period, however, it did not translate into worse survival during follow-up. MDPI 2021-11-25 /pmc/articles/PMC8708571/ /pubmed/34946241 http://dx.doi.org/10.3390/medicina57121296 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Budrys, Povilas Lizaitis, Mindaugas Cerlinskaite-Bajore, Kamile Bajoras, Vilhelmas Rodevic, Greta Martinonyte, Aurelija Dieckus, Laurynas Badaras, Ignas Serpytis, Pranas Gurevicius, Romualdas Visinskiene, Rasa Buivydas, Romualdas Volodko, Aleksandr Urbonaite, Egle Celutkiene, Jelena Davidavicius, Giedrius Increase of Myocardial Ischemia Time and Short-Term Prognosis of Patients with Acute Myocardial Infarction during the First COVID-19 Pandemic Wave |
title | Increase of Myocardial Ischemia Time and Short-Term Prognosis of Patients with Acute Myocardial Infarction during the First COVID-19 Pandemic Wave |
title_full | Increase of Myocardial Ischemia Time and Short-Term Prognosis of Patients with Acute Myocardial Infarction during the First COVID-19 Pandemic Wave |
title_fullStr | Increase of Myocardial Ischemia Time and Short-Term Prognosis of Patients with Acute Myocardial Infarction during the First COVID-19 Pandemic Wave |
title_full_unstemmed | Increase of Myocardial Ischemia Time and Short-Term Prognosis of Patients with Acute Myocardial Infarction during the First COVID-19 Pandemic Wave |
title_short | Increase of Myocardial Ischemia Time and Short-Term Prognosis of Patients with Acute Myocardial Infarction during the First COVID-19 Pandemic Wave |
title_sort | increase of myocardial ischemia time and short-term prognosis of patients with acute myocardial infarction during the first covid-19 pandemic wave |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708571/ https://www.ncbi.nlm.nih.gov/pubmed/34946241 http://dx.doi.org/10.3390/medicina57121296 |
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