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Increase of Myocardial Ischemia Time and Short-Term Prognosis of Patients with Acute Myocardial Infarction during the First COVID-19 Pandemic Wave

Background and objectives: early reports showed a decrease in admission rates and an increase in mortality of patients with acute myocardial infarction (AMI) during the first wave of COVID-19 pandemic. We sought to investigate whether the COVID-19 pandemic and associated lockdown had an impact on th...

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Autores principales: Budrys, Povilas, Lizaitis, Mindaugas, Cerlinskaite-Bajore, Kamile, Bajoras, Vilhelmas, Rodevic, Greta, Martinonyte, Aurelija, Dieckus, Laurynas, Badaras, Ignas, Serpytis, Pranas, Gurevicius, Romualdas, Visinskiene, Rasa, Buivydas, Romualdas, Volodko, Aleksandr, Urbonaite, Egle, Celutkiene, Jelena, Davidavicius, Giedrius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708571/
https://www.ncbi.nlm.nih.gov/pubmed/34946241
http://dx.doi.org/10.3390/medicina57121296
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author Budrys, Povilas
Lizaitis, Mindaugas
Cerlinskaite-Bajore, Kamile
Bajoras, Vilhelmas
Rodevic, Greta
Martinonyte, Aurelija
Dieckus, Laurynas
Badaras, Ignas
Serpytis, Pranas
Gurevicius, Romualdas
Visinskiene, Rasa
Buivydas, Romualdas
Volodko, Aleksandr
Urbonaite, Egle
Celutkiene, Jelena
Davidavicius, Giedrius
author_facet Budrys, Povilas
Lizaitis, Mindaugas
Cerlinskaite-Bajore, Kamile
Bajoras, Vilhelmas
Rodevic, Greta
Martinonyte, Aurelija
Dieckus, Laurynas
Badaras, Ignas
Serpytis, Pranas
Gurevicius, Romualdas
Visinskiene, Rasa
Buivydas, Romualdas
Volodko, Aleksandr
Urbonaite, Egle
Celutkiene, Jelena
Davidavicius, Giedrius
author_sort Budrys, Povilas
collection PubMed
description Background and objectives: early reports showed a decrease in admission rates and an increase in mortality of patients with acute myocardial infarction (AMI) during the first wave of COVID-19 pandemic. We sought to investigate whether the COVID-19 pandemic and associated lockdown had an impact on the ischemia time and prognosis of patients suffering from AMI in the settings of low COVID-19 burden. Materials and Methods: we conducted a retrospective data analysis from a tertiary center in Lithuania of 818 patients with AMI. Data were collected from 1 March to 30 June in 2020 during the peri-lockdown period (2020 group; n = 278) and compared to the same period last year (2019 group; n = 326). The primary study endpoint was all-cause mortality during 3 months of follow-up. Secondary endpoints were heart failure severity (Killip class) on admission and ischemia time in patients with acute ST segment elevation myocardial infarction (STEMI). Results: there was a reduction of 14.7% in admission rate for acute myocardial infarction (AMI) during the peri-lockdown period. The 3-month mortality rate did not differ significantly (6.9% in 2020 vs. 10.5% in 2019, p = 0.341 for STEMI patients; 5.3% in 2020 vs. 2.6% in 2019, p = 0.374 for patients with acute myocardial infarction without ST segment elevation (NSTEMI)). More STEMI patients presented with Killip IV class in 2019 (13.5% vs. 5.5%, p = 0.043, respectively). There was an increase of door-to-PCI time (54.0 [42.0–86.0] in 2019; 63.5 [48.3–97.5] in 2020, p = 0.018) and first medical contact (FMC)-to-PCI time (101.0 [82.5–120.8] in 2019; 115 [97.0–154.5] in 2020, p = 0.01) during the pandemic period. Conclusions: There was a 14.7% reduction of admissions for AMI during the first wave of COVID-19. FMC-to-PCI time increased during the peri-lockdown period, however, it did not translate into worse survival during follow-up.
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spelling pubmed-87085712021-12-25 Increase of Myocardial Ischemia Time and Short-Term Prognosis of Patients with Acute Myocardial Infarction during the First COVID-19 Pandemic Wave Budrys, Povilas Lizaitis, Mindaugas Cerlinskaite-Bajore, Kamile Bajoras, Vilhelmas Rodevic, Greta Martinonyte, Aurelija Dieckus, Laurynas Badaras, Ignas Serpytis, Pranas Gurevicius, Romualdas Visinskiene, Rasa Buivydas, Romualdas Volodko, Aleksandr Urbonaite, Egle Celutkiene, Jelena Davidavicius, Giedrius Medicina (Kaunas) Article Background and objectives: early reports showed a decrease in admission rates and an increase in mortality of patients with acute myocardial infarction (AMI) during the first wave of COVID-19 pandemic. We sought to investigate whether the COVID-19 pandemic and associated lockdown had an impact on the ischemia time and prognosis of patients suffering from AMI in the settings of low COVID-19 burden. Materials and Methods: we conducted a retrospective data analysis from a tertiary center in Lithuania of 818 patients with AMI. Data were collected from 1 March to 30 June in 2020 during the peri-lockdown period (2020 group; n = 278) and compared to the same period last year (2019 group; n = 326). The primary study endpoint was all-cause mortality during 3 months of follow-up. Secondary endpoints were heart failure severity (Killip class) on admission and ischemia time in patients with acute ST segment elevation myocardial infarction (STEMI). Results: there was a reduction of 14.7% in admission rate for acute myocardial infarction (AMI) during the peri-lockdown period. The 3-month mortality rate did not differ significantly (6.9% in 2020 vs. 10.5% in 2019, p = 0.341 for STEMI patients; 5.3% in 2020 vs. 2.6% in 2019, p = 0.374 for patients with acute myocardial infarction without ST segment elevation (NSTEMI)). More STEMI patients presented with Killip IV class in 2019 (13.5% vs. 5.5%, p = 0.043, respectively). There was an increase of door-to-PCI time (54.0 [42.0–86.0] in 2019; 63.5 [48.3–97.5] in 2020, p = 0.018) and first medical contact (FMC)-to-PCI time (101.0 [82.5–120.8] in 2019; 115 [97.0–154.5] in 2020, p = 0.01) during the pandemic period. Conclusions: There was a 14.7% reduction of admissions for AMI during the first wave of COVID-19. FMC-to-PCI time increased during the peri-lockdown period, however, it did not translate into worse survival during follow-up. MDPI 2021-11-25 /pmc/articles/PMC8708571/ /pubmed/34946241 http://dx.doi.org/10.3390/medicina57121296 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Budrys, Povilas
Lizaitis, Mindaugas
Cerlinskaite-Bajore, Kamile
Bajoras, Vilhelmas
Rodevic, Greta
Martinonyte, Aurelija
Dieckus, Laurynas
Badaras, Ignas
Serpytis, Pranas
Gurevicius, Romualdas
Visinskiene, Rasa
Buivydas, Romualdas
Volodko, Aleksandr
Urbonaite, Egle
Celutkiene, Jelena
Davidavicius, Giedrius
Increase of Myocardial Ischemia Time and Short-Term Prognosis of Patients with Acute Myocardial Infarction during the First COVID-19 Pandemic Wave
title Increase of Myocardial Ischemia Time and Short-Term Prognosis of Patients with Acute Myocardial Infarction during the First COVID-19 Pandemic Wave
title_full Increase of Myocardial Ischemia Time and Short-Term Prognosis of Patients with Acute Myocardial Infarction during the First COVID-19 Pandemic Wave
title_fullStr Increase of Myocardial Ischemia Time and Short-Term Prognosis of Patients with Acute Myocardial Infarction during the First COVID-19 Pandemic Wave
title_full_unstemmed Increase of Myocardial Ischemia Time and Short-Term Prognosis of Patients with Acute Myocardial Infarction during the First COVID-19 Pandemic Wave
title_short Increase of Myocardial Ischemia Time and Short-Term Prognosis of Patients with Acute Myocardial Infarction during the First COVID-19 Pandemic Wave
title_sort increase of myocardial ischemia time and short-term prognosis of patients with acute myocardial infarction during the first covid-19 pandemic wave
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708571/
https://www.ncbi.nlm.nih.gov/pubmed/34946241
http://dx.doi.org/10.3390/medicina57121296
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