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SARS-CoV-2 Infection in Patients on Dialysis: Incidence and Outcomes in the Lazio Region, Italy
Patients with end-stage kidney disease represent a frail population and might be at higher risk of SARS-CoV-2 infection. The Lazio Regional Dialysis and Transplant Registry collected information on dialysis patients with a positive swab. The study investigated incidence of SARS-CoV-2 infection, mort...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708577/ https://www.ncbi.nlm.nih.gov/pubmed/34945114 http://dx.doi.org/10.3390/jcm10245818 |
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author | Marino, Claudia Angelici, Laura Pistolesi, Valentina Morabito, Santo Di Napoli, Anteo Calandrini, Enrico Cascini, Silvia Bargagli, Anna Maria Petrosillo, Nicola Agabiti, Nera Davoli, Marina |
author_facet | Marino, Claudia Angelici, Laura Pistolesi, Valentina Morabito, Santo Di Napoli, Anteo Calandrini, Enrico Cascini, Silvia Bargagli, Anna Maria Petrosillo, Nicola Agabiti, Nera Davoli, Marina |
author_sort | Marino, Claudia |
collection | PubMed |
description | Patients with end-stage kidney disease represent a frail population and might be at higher risk of SARS-CoV-2 infection. The Lazio Regional Dialysis and Transplant Registry collected information on dialysis patients with a positive swab. The study investigated incidence of SARS-CoV-2 infection, mortality and their potential associated factors in patients undergoing maintenance hemodialysis (MHD) in the Lazio region. Method: The occurrence of infection was assessed among MHD patients included in the RRDTL from 1 March to 30 November 2020. The adjusted cumulative incidence of infection and mortality risk within 30 days of infection onset were estimated. Logistic and Cox regression models were applied to identify factors associated with infection and mortality, respectively. Results: The MHD cohort counted 4942 patients; 256 (5.2%) had COVID-19. The adjusted cumulative incidence was 5.1%. Factors associated with infection included: being born abroad, educational level, cystic renal disease/familial nephropathy, vascular disease and being treated in a dialysis center located in Local Health Authority (LHA) Rome 2. Among infected patients, 59 (23.0%) died within 30 days; the adjusted mortality risk was 21.0%. Factors associated with 30-day mortality included: age, malnutrition and fever at the time of swab. Conclusions: Factors associated with infection seem to reflect socioeconomic conditions. Factors associated with mortality, in addition to age, are related to clinical characteristics and symptoms at the time of swab. |
format | Online Article Text |
id | pubmed-8708577 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87085772021-12-25 SARS-CoV-2 Infection in Patients on Dialysis: Incidence and Outcomes in the Lazio Region, Italy Marino, Claudia Angelici, Laura Pistolesi, Valentina Morabito, Santo Di Napoli, Anteo Calandrini, Enrico Cascini, Silvia Bargagli, Anna Maria Petrosillo, Nicola Agabiti, Nera Davoli, Marina J Clin Med Article Patients with end-stage kidney disease represent a frail population and might be at higher risk of SARS-CoV-2 infection. The Lazio Regional Dialysis and Transplant Registry collected information on dialysis patients with a positive swab. The study investigated incidence of SARS-CoV-2 infection, mortality and their potential associated factors in patients undergoing maintenance hemodialysis (MHD) in the Lazio region. Method: The occurrence of infection was assessed among MHD patients included in the RRDTL from 1 March to 30 November 2020. The adjusted cumulative incidence of infection and mortality risk within 30 days of infection onset were estimated. Logistic and Cox regression models were applied to identify factors associated with infection and mortality, respectively. Results: The MHD cohort counted 4942 patients; 256 (5.2%) had COVID-19. The adjusted cumulative incidence was 5.1%. Factors associated with infection included: being born abroad, educational level, cystic renal disease/familial nephropathy, vascular disease and being treated in a dialysis center located in Local Health Authority (LHA) Rome 2. Among infected patients, 59 (23.0%) died within 30 days; the adjusted mortality risk was 21.0%. Factors associated with 30-day mortality included: age, malnutrition and fever at the time of swab. Conclusions: Factors associated with infection seem to reflect socioeconomic conditions. Factors associated with mortality, in addition to age, are related to clinical characteristics and symptoms at the time of swab. MDPI 2021-12-13 /pmc/articles/PMC8708577/ /pubmed/34945114 http://dx.doi.org/10.3390/jcm10245818 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Marino, Claudia Angelici, Laura Pistolesi, Valentina Morabito, Santo Di Napoli, Anteo Calandrini, Enrico Cascini, Silvia Bargagli, Anna Maria Petrosillo, Nicola Agabiti, Nera Davoli, Marina SARS-CoV-2 Infection in Patients on Dialysis: Incidence and Outcomes in the Lazio Region, Italy |
title | SARS-CoV-2 Infection in Patients on Dialysis: Incidence and Outcomes in the Lazio Region, Italy |
title_full | SARS-CoV-2 Infection in Patients on Dialysis: Incidence and Outcomes in the Lazio Region, Italy |
title_fullStr | SARS-CoV-2 Infection in Patients on Dialysis: Incidence and Outcomes in the Lazio Region, Italy |
title_full_unstemmed | SARS-CoV-2 Infection in Patients on Dialysis: Incidence and Outcomes in the Lazio Region, Italy |
title_short | SARS-CoV-2 Infection in Patients on Dialysis: Incidence and Outcomes in the Lazio Region, Italy |
title_sort | sars-cov-2 infection in patients on dialysis: incidence and outcomes in the lazio region, italy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708577/ https://www.ncbi.nlm.nih.gov/pubmed/34945114 http://dx.doi.org/10.3390/jcm10245818 |
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