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Application of Sebum Lipidomics to Biomarkers Discovery in Neurodegenerative Diseases

Lipidomics is strategic in the discovery of biomarkers of neurodegenerative diseases (NDDs). The skin surface lipidome bears the potential to provide biomarker candidates in the detection of pathological processes occurring in distal organs. We investigated the sebum composition to search diagnostic...

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Autores principales: Briganti, Stefania, Truglio, Mauro, Angiolillo, Antonella, Lombardo, Salvatore, Leccese, Deborah, Camera, Emanuela, Picardo, Mauro, Di Costanzo, Alfonso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708591/
https://www.ncbi.nlm.nih.gov/pubmed/34940576
http://dx.doi.org/10.3390/metabo11120819
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author Briganti, Stefania
Truglio, Mauro
Angiolillo, Antonella
Lombardo, Salvatore
Leccese, Deborah
Camera, Emanuela
Picardo, Mauro
Di Costanzo, Alfonso
author_facet Briganti, Stefania
Truglio, Mauro
Angiolillo, Antonella
Lombardo, Salvatore
Leccese, Deborah
Camera, Emanuela
Picardo, Mauro
Di Costanzo, Alfonso
author_sort Briganti, Stefania
collection PubMed
description Lipidomics is strategic in the discovery of biomarkers of neurodegenerative diseases (NDDs). The skin surface lipidome bears the potential to provide biomarker candidates in the detection of pathological processes occurring in distal organs. We investigated the sebum composition to search diagnostic and, possibly, prognostic, biomarkers of Alzheimer’s disease (AD) and Parkinson’s disease (PD). The observational study included 64 subjects: 20 characterized as “probable AD with documented decline”, 20 as “clinically established PD”, and 24 healthy subjects (HS) of comparable age. The analysis of sebum by GCMS and TLC retrieved the amounts (µg) of 41 free fatty acids (FFAs), 7 fatty alcohols (FOHs), vitamin E, cholesterol, squalene, and total triglycerides (TGs) and wax esters (WEs). Distributions of sebum lipids in NDDs and healthy conditions were investigated with multivariate ANOVA-simultaneous component analysis (ASCA). The deranged sebum composition associated with the PD group showed incretion of most composing lipids compared to HS, whereas only two lipid species (vitamin E and FOH14:0) were discriminant of AD samples and presented lower levels than HS sebum. Thus, sebum lipid biosynthetic pathways are differently affected in PD and AD. The characteristic sebum bio-signatures detected support the value of sebum lipidomics in the biomarkers search in NDDs.
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spelling pubmed-87085912021-12-25 Application of Sebum Lipidomics to Biomarkers Discovery in Neurodegenerative Diseases Briganti, Stefania Truglio, Mauro Angiolillo, Antonella Lombardo, Salvatore Leccese, Deborah Camera, Emanuela Picardo, Mauro Di Costanzo, Alfonso Metabolites Article Lipidomics is strategic in the discovery of biomarkers of neurodegenerative diseases (NDDs). The skin surface lipidome bears the potential to provide biomarker candidates in the detection of pathological processes occurring in distal organs. We investigated the sebum composition to search diagnostic and, possibly, prognostic, biomarkers of Alzheimer’s disease (AD) and Parkinson’s disease (PD). The observational study included 64 subjects: 20 characterized as “probable AD with documented decline”, 20 as “clinically established PD”, and 24 healthy subjects (HS) of comparable age. The analysis of sebum by GCMS and TLC retrieved the amounts (µg) of 41 free fatty acids (FFAs), 7 fatty alcohols (FOHs), vitamin E, cholesterol, squalene, and total triglycerides (TGs) and wax esters (WEs). Distributions of sebum lipids in NDDs and healthy conditions were investigated with multivariate ANOVA-simultaneous component analysis (ASCA). The deranged sebum composition associated with the PD group showed incretion of most composing lipids compared to HS, whereas only two lipid species (vitamin E and FOH14:0) were discriminant of AD samples and presented lower levels than HS sebum. Thus, sebum lipid biosynthetic pathways are differently affected in PD and AD. The characteristic sebum bio-signatures detected support the value of sebum lipidomics in the biomarkers search in NDDs. MDPI 2021-11-29 /pmc/articles/PMC8708591/ /pubmed/34940576 http://dx.doi.org/10.3390/metabo11120819 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Briganti, Stefania
Truglio, Mauro
Angiolillo, Antonella
Lombardo, Salvatore
Leccese, Deborah
Camera, Emanuela
Picardo, Mauro
Di Costanzo, Alfonso
Application of Sebum Lipidomics to Biomarkers Discovery in Neurodegenerative Diseases
title Application of Sebum Lipidomics to Biomarkers Discovery in Neurodegenerative Diseases
title_full Application of Sebum Lipidomics to Biomarkers Discovery in Neurodegenerative Diseases
title_fullStr Application of Sebum Lipidomics to Biomarkers Discovery in Neurodegenerative Diseases
title_full_unstemmed Application of Sebum Lipidomics to Biomarkers Discovery in Neurodegenerative Diseases
title_short Application of Sebum Lipidomics to Biomarkers Discovery in Neurodegenerative Diseases
title_sort application of sebum lipidomics to biomarkers discovery in neurodegenerative diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708591/
https://www.ncbi.nlm.nih.gov/pubmed/34940576
http://dx.doi.org/10.3390/metabo11120819
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