Protein-Based Nanoparticles for the Imaging and Treatment of Solid Tumors: The Case of Ferritin Nanocages, a Narrative Review

Protein nanocages have been studied extensively, due to their unique architecture, exceptional biocompatibility and highly customization capabilities. In particular, ferritin nanocages (FNs) have been employed for the delivery of a vast array of molecules, ranging from chemotherapeutics to imaging a...

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Autores principales: Mainini, Francesco, Bonizzi, Arianna, Sevieri, Marta, Sitia, Leopoldo, Truffi, Marta, Corsi, Fabio, Mazzucchelli, Serena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708614/
https://www.ncbi.nlm.nih.gov/pubmed/34959283
http://dx.doi.org/10.3390/pharmaceutics13122000
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author Mainini, Francesco
Bonizzi, Arianna
Sevieri, Marta
Sitia, Leopoldo
Truffi, Marta
Corsi, Fabio
Mazzucchelli, Serena
author_facet Mainini, Francesco
Bonizzi, Arianna
Sevieri, Marta
Sitia, Leopoldo
Truffi, Marta
Corsi, Fabio
Mazzucchelli, Serena
author_sort Mainini, Francesco
collection PubMed
description Protein nanocages have been studied extensively, due to their unique architecture, exceptional biocompatibility and highly customization capabilities. In particular, ferritin nanocages (FNs) have been employed for the delivery of a vast array of molecules, ranging from chemotherapeutics to imaging agents, among others. One of the main favorable characteristics of FNs is their intrinsic targeting efficiency toward the Transferrin Receptor 1, which is overexpressed in many tumors. Furthermore, genetic manipulation can be employed to introduce novel variants that are able to improve the loading capacity, targeting capabilities and bio-availability of this versatile drug delivery system. In this review, we discuss the main characteristics of FN and the most recent applications of this promising nanotechnology in the field of oncology with a particular emphasis on the imaging and treatment of solid tumors.
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spelling pubmed-87086142021-12-25 Protein-Based Nanoparticles for the Imaging and Treatment of Solid Tumors: The Case of Ferritin Nanocages, a Narrative Review Mainini, Francesco Bonizzi, Arianna Sevieri, Marta Sitia, Leopoldo Truffi, Marta Corsi, Fabio Mazzucchelli, Serena Pharmaceutics Review Protein nanocages have been studied extensively, due to their unique architecture, exceptional biocompatibility and highly customization capabilities. In particular, ferritin nanocages (FNs) have been employed for the delivery of a vast array of molecules, ranging from chemotherapeutics to imaging agents, among others. One of the main favorable characteristics of FNs is their intrinsic targeting efficiency toward the Transferrin Receptor 1, which is overexpressed in many tumors. Furthermore, genetic manipulation can be employed to introduce novel variants that are able to improve the loading capacity, targeting capabilities and bio-availability of this versatile drug delivery system. In this review, we discuss the main characteristics of FN and the most recent applications of this promising nanotechnology in the field of oncology with a particular emphasis on the imaging and treatment of solid tumors. MDPI 2021-11-25 /pmc/articles/PMC8708614/ /pubmed/34959283 http://dx.doi.org/10.3390/pharmaceutics13122000 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mainini, Francesco
Bonizzi, Arianna
Sevieri, Marta
Sitia, Leopoldo
Truffi, Marta
Corsi, Fabio
Mazzucchelli, Serena
Protein-Based Nanoparticles for the Imaging and Treatment of Solid Tumors: The Case of Ferritin Nanocages, a Narrative Review
title Protein-Based Nanoparticles for the Imaging and Treatment of Solid Tumors: The Case of Ferritin Nanocages, a Narrative Review
title_full Protein-Based Nanoparticles for the Imaging and Treatment of Solid Tumors: The Case of Ferritin Nanocages, a Narrative Review
title_fullStr Protein-Based Nanoparticles for the Imaging and Treatment of Solid Tumors: The Case of Ferritin Nanocages, a Narrative Review
title_full_unstemmed Protein-Based Nanoparticles for the Imaging and Treatment of Solid Tumors: The Case of Ferritin Nanocages, a Narrative Review
title_short Protein-Based Nanoparticles for the Imaging and Treatment of Solid Tumors: The Case of Ferritin Nanocages, a Narrative Review
title_sort protein-based nanoparticles for the imaging and treatment of solid tumors: the case of ferritin nanocages, a narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708614/
https://www.ncbi.nlm.nih.gov/pubmed/34959283
http://dx.doi.org/10.3390/pharmaceutics13122000
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