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Nutrient Intake and Dietary Inflammatory Potential in Current and Recovered Anorexia Nervosa

Anorexia nervosa (AN) is characterised by disrupted and restrictive eating patterns. Recent investigations and meta-analyses have found altered concentrations of inflammatory markers in people with current AN. We aimed to assess nutrient intake in participants with current or recovered AN, as compar...

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Autores principales: Patsalos, Olivia, Dalton, Bethan, Kyprianou, Christia, Firth, Joseph, Shivappa, Nitin, Hébert, James R., Schmidt, Ulrike, Himmerich, Hubertus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708616/
https://www.ncbi.nlm.nih.gov/pubmed/34959952
http://dx.doi.org/10.3390/nu13124400
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author Patsalos, Olivia
Dalton, Bethan
Kyprianou, Christia
Firth, Joseph
Shivappa, Nitin
Hébert, James R.
Schmidt, Ulrike
Himmerich, Hubertus
author_facet Patsalos, Olivia
Dalton, Bethan
Kyprianou, Christia
Firth, Joseph
Shivappa, Nitin
Hébert, James R.
Schmidt, Ulrike
Himmerich, Hubertus
author_sort Patsalos, Olivia
collection PubMed
description Anorexia nervosa (AN) is characterised by disrupted and restrictive eating patterns. Recent investigations and meta-analyses have found altered concentrations of inflammatory markers in people with current AN. We aimed to assess nutrient intake in participants with current or recovered AN, as compared to healthy individuals, and explore group differences in dietary inflammatory potential as a possible explanation for the observed alterations in inflammatory markers. We recruited participants with current AN (n = 51), those recovered from AN (n = 23), and healthy controls (n = 49). We used the Food Frequency Questionnaire (FFQ), to calculate a Dietary Inflammatory Index (DII(®)) score and collected blood samples to measure serum concentrations of inflammatory markers. In current AN participants, we found lower intake of cholesterol, compared to HCs, and lower consumption of zinc and protein, compared to HC and recovered AN participants. A one-way ANOVA revealed no significant group differences in DII score. Multivariable regression analyses showed that DII scores were significantly associated with tumour necrosis factor (TNF)-α concentrations in our current AN sample. Our findings on nutrient intake are partially consistent with previous research. The lack of group differences in DII score, perhaps suggests that diet is not a key contributor to altered inflammatory marker concentrations in current and recovered AN. Future research would benefit from including larger samples and using multiple 24-h dietary recalls to assess dietary intake.
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spelling pubmed-87086162021-12-25 Nutrient Intake and Dietary Inflammatory Potential in Current and Recovered Anorexia Nervosa Patsalos, Olivia Dalton, Bethan Kyprianou, Christia Firth, Joseph Shivappa, Nitin Hébert, James R. Schmidt, Ulrike Himmerich, Hubertus Nutrients Article Anorexia nervosa (AN) is characterised by disrupted and restrictive eating patterns. Recent investigations and meta-analyses have found altered concentrations of inflammatory markers in people with current AN. We aimed to assess nutrient intake in participants with current or recovered AN, as compared to healthy individuals, and explore group differences in dietary inflammatory potential as a possible explanation for the observed alterations in inflammatory markers. We recruited participants with current AN (n = 51), those recovered from AN (n = 23), and healthy controls (n = 49). We used the Food Frequency Questionnaire (FFQ), to calculate a Dietary Inflammatory Index (DII(®)) score and collected blood samples to measure serum concentrations of inflammatory markers. In current AN participants, we found lower intake of cholesterol, compared to HCs, and lower consumption of zinc and protein, compared to HC and recovered AN participants. A one-way ANOVA revealed no significant group differences in DII score. Multivariable regression analyses showed that DII scores were significantly associated with tumour necrosis factor (TNF)-α concentrations in our current AN sample. Our findings on nutrient intake are partially consistent with previous research. The lack of group differences in DII score, perhaps suggests that diet is not a key contributor to altered inflammatory marker concentrations in current and recovered AN. Future research would benefit from including larger samples and using multiple 24-h dietary recalls to assess dietary intake. MDPI 2021-12-09 /pmc/articles/PMC8708616/ /pubmed/34959952 http://dx.doi.org/10.3390/nu13124400 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Patsalos, Olivia
Dalton, Bethan
Kyprianou, Christia
Firth, Joseph
Shivappa, Nitin
Hébert, James R.
Schmidt, Ulrike
Himmerich, Hubertus
Nutrient Intake and Dietary Inflammatory Potential in Current and Recovered Anorexia Nervosa
title Nutrient Intake and Dietary Inflammatory Potential in Current and Recovered Anorexia Nervosa
title_full Nutrient Intake and Dietary Inflammatory Potential in Current and Recovered Anorexia Nervosa
title_fullStr Nutrient Intake and Dietary Inflammatory Potential in Current and Recovered Anorexia Nervosa
title_full_unstemmed Nutrient Intake and Dietary Inflammatory Potential in Current and Recovered Anorexia Nervosa
title_short Nutrient Intake and Dietary Inflammatory Potential in Current and Recovered Anorexia Nervosa
title_sort nutrient intake and dietary inflammatory potential in current and recovered anorexia nervosa
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708616/
https://www.ncbi.nlm.nih.gov/pubmed/34959952
http://dx.doi.org/10.3390/nu13124400
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