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Single-Fiber Diffuse Reflectance Spectroscopy and Spatial Frequency Domain Imaging in Surgery Guidance: A Study on Optical Phantoms

Diffuse reflectance spectroscopy (DRS) and imaging are increasingly being used in surgical guidance for tumor margin detection during endoscopic operations. However, the accuracy of the boundary detection with optical techniques may depend on the acquisition parameters, and its evaluation is in high...

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Autores principales: Tseregorodtseva, Polina S., Buiankin, Kirill E., Yakimov, Boris P., Kamalov, Armais A., Budylin, Gleb S., Shirshin, Evgeny A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708622/
https://www.ncbi.nlm.nih.gov/pubmed/34947102
http://dx.doi.org/10.3390/ma14247502
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author Tseregorodtseva, Polina S.
Buiankin, Kirill E.
Yakimov, Boris P.
Kamalov, Armais A.
Budylin, Gleb S.
Shirshin, Evgeny A.
author_facet Tseregorodtseva, Polina S.
Buiankin, Kirill E.
Yakimov, Boris P.
Kamalov, Armais A.
Budylin, Gleb S.
Shirshin, Evgeny A.
author_sort Tseregorodtseva, Polina S.
collection PubMed
description Diffuse reflectance spectroscopy (DRS) and imaging are increasingly being used in surgical guidance for tumor margin detection during endoscopic operations. However, the accuracy of the boundary detection with optical techniques may depend on the acquisition parameters, and its evaluation is in high demand. In this work, using optical phantoms with homogeneous and heterogeneous distribution of chromophores mimicking normal and pathological bladder tissues, the accuracy of tumor margin detection using single-fiber diffuse reflectance spectroscopy and spatial frequency domain imaging was evaluated. We also showed how the diffuse reflectance response obtained at different spatial frequencies with the spatial frequency domain imaging technique could be used not only to quantitatively map absorption and scattering coefficients of normal tissues and tumor-like heterogeneities but also to estimate the tumor depth localization. The demonstrated results could be helpful for proper analysis of the DRS data measured in vivo and for translation of optical techniques for tumor margin detection to clinics.
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spelling pubmed-87086222021-12-25 Single-Fiber Diffuse Reflectance Spectroscopy and Spatial Frequency Domain Imaging in Surgery Guidance: A Study on Optical Phantoms Tseregorodtseva, Polina S. Buiankin, Kirill E. Yakimov, Boris P. Kamalov, Armais A. Budylin, Gleb S. Shirshin, Evgeny A. Materials (Basel) Article Diffuse reflectance spectroscopy (DRS) and imaging are increasingly being used in surgical guidance for tumor margin detection during endoscopic operations. However, the accuracy of the boundary detection with optical techniques may depend on the acquisition parameters, and its evaluation is in high demand. In this work, using optical phantoms with homogeneous and heterogeneous distribution of chromophores mimicking normal and pathological bladder tissues, the accuracy of tumor margin detection using single-fiber diffuse reflectance spectroscopy and spatial frequency domain imaging was evaluated. We also showed how the diffuse reflectance response obtained at different spatial frequencies with the spatial frequency domain imaging technique could be used not only to quantitatively map absorption and scattering coefficients of normal tissues and tumor-like heterogeneities but also to estimate the tumor depth localization. The demonstrated results could be helpful for proper analysis of the DRS data measured in vivo and for translation of optical techniques for tumor margin detection to clinics. MDPI 2021-12-07 /pmc/articles/PMC8708622/ /pubmed/34947102 http://dx.doi.org/10.3390/ma14247502 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tseregorodtseva, Polina S.
Buiankin, Kirill E.
Yakimov, Boris P.
Kamalov, Armais A.
Budylin, Gleb S.
Shirshin, Evgeny A.
Single-Fiber Diffuse Reflectance Spectroscopy and Spatial Frequency Domain Imaging in Surgery Guidance: A Study on Optical Phantoms
title Single-Fiber Diffuse Reflectance Spectroscopy and Spatial Frequency Domain Imaging in Surgery Guidance: A Study on Optical Phantoms
title_full Single-Fiber Diffuse Reflectance Spectroscopy and Spatial Frequency Domain Imaging in Surgery Guidance: A Study on Optical Phantoms
title_fullStr Single-Fiber Diffuse Reflectance Spectroscopy and Spatial Frequency Domain Imaging in Surgery Guidance: A Study on Optical Phantoms
title_full_unstemmed Single-Fiber Diffuse Reflectance Spectroscopy and Spatial Frequency Domain Imaging in Surgery Guidance: A Study on Optical Phantoms
title_short Single-Fiber Diffuse Reflectance Spectroscopy and Spatial Frequency Domain Imaging in Surgery Guidance: A Study on Optical Phantoms
title_sort single-fiber diffuse reflectance spectroscopy and spatial frequency domain imaging in surgery guidance: a study on optical phantoms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708622/
https://www.ncbi.nlm.nih.gov/pubmed/34947102
http://dx.doi.org/10.3390/ma14247502
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