Cargando…
Single-Fiber Diffuse Reflectance Spectroscopy and Spatial Frequency Domain Imaging in Surgery Guidance: A Study on Optical Phantoms
Diffuse reflectance spectroscopy (DRS) and imaging are increasingly being used in surgical guidance for tumor margin detection during endoscopic operations. However, the accuracy of the boundary detection with optical techniques may depend on the acquisition parameters, and its evaluation is in high...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708622/ https://www.ncbi.nlm.nih.gov/pubmed/34947102 http://dx.doi.org/10.3390/ma14247502 |
_version_ | 1784622731296243712 |
---|---|
author | Tseregorodtseva, Polina S. Buiankin, Kirill E. Yakimov, Boris P. Kamalov, Armais A. Budylin, Gleb S. Shirshin, Evgeny A. |
author_facet | Tseregorodtseva, Polina S. Buiankin, Kirill E. Yakimov, Boris P. Kamalov, Armais A. Budylin, Gleb S. Shirshin, Evgeny A. |
author_sort | Tseregorodtseva, Polina S. |
collection | PubMed |
description | Diffuse reflectance spectroscopy (DRS) and imaging are increasingly being used in surgical guidance for tumor margin detection during endoscopic operations. However, the accuracy of the boundary detection with optical techniques may depend on the acquisition parameters, and its evaluation is in high demand. In this work, using optical phantoms with homogeneous and heterogeneous distribution of chromophores mimicking normal and pathological bladder tissues, the accuracy of tumor margin detection using single-fiber diffuse reflectance spectroscopy and spatial frequency domain imaging was evaluated. We also showed how the diffuse reflectance response obtained at different spatial frequencies with the spatial frequency domain imaging technique could be used not only to quantitatively map absorption and scattering coefficients of normal tissues and tumor-like heterogeneities but also to estimate the tumor depth localization. The demonstrated results could be helpful for proper analysis of the DRS data measured in vivo and for translation of optical techniques for tumor margin detection to clinics. |
format | Online Article Text |
id | pubmed-8708622 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87086222021-12-25 Single-Fiber Diffuse Reflectance Spectroscopy and Spatial Frequency Domain Imaging in Surgery Guidance: A Study on Optical Phantoms Tseregorodtseva, Polina S. Buiankin, Kirill E. Yakimov, Boris P. Kamalov, Armais A. Budylin, Gleb S. Shirshin, Evgeny A. Materials (Basel) Article Diffuse reflectance spectroscopy (DRS) and imaging are increasingly being used in surgical guidance for tumor margin detection during endoscopic operations. However, the accuracy of the boundary detection with optical techniques may depend on the acquisition parameters, and its evaluation is in high demand. In this work, using optical phantoms with homogeneous and heterogeneous distribution of chromophores mimicking normal and pathological bladder tissues, the accuracy of tumor margin detection using single-fiber diffuse reflectance spectroscopy and spatial frequency domain imaging was evaluated. We also showed how the diffuse reflectance response obtained at different spatial frequencies with the spatial frequency domain imaging technique could be used not only to quantitatively map absorption and scattering coefficients of normal tissues and tumor-like heterogeneities but also to estimate the tumor depth localization. The demonstrated results could be helpful for proper analysis of the DRS data measured in vivo and for translation of optical techniques for tumor margin detection to clinics. MDPI 2021-12-07 /pmc/articles/PMC8708622/ /pubmed/34947102 http://dx.doi.org/10.3390/ma14247502 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tseregorodtseva, Polina S. Buiankin, Kirill E. Yakimov, Boris P. Kamalov, Armais A. Budylin, Gleb S. Shirshin, Evgeny A. Single-Fiber Diffuse Reflectance Spectroscopy and Spatial Frequency Domain Imaging in Surgery Guidance: A Study on Optical Phantoms |
title | Single-Fiber Diffuse Reflectance Spectroscopy and Spatial Frequency Domain Imaging in Surgery Guidance: A Study on Optical Phantoms |
title_full | Single-Fiber Diffuse Reflectance Spectroscopy and Spatial Frequency Domain Imaging in Surgery Guidance: A Study on Optical Phantoms |
title_fullStr | Single-Fiber Diffuse Reflectance Spectroscopy and Spatial Frequency Domain Imaging in Surgery Guidance: A Study on Optical Phantoms |
title_full_unstemmed | Single-Fiber Diffuse Reflectance Spectroscopy and Spatial Frequency Domain Imaging in Surgery Guidance: A Study on Optical Phantoms |
title_short | Single-Fiber Diffuse Reflectance Spectroscopy and Spatial Frequency Domain Imaging in Surgery Guidance: A Study on Optical Phantoms |
title_sort | single-fiber diffuse reflectance spectroscopy and spatial frequency domain imaging in surgery guidance: a study on optical phantoms |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708622/ https://www.ncbi.nlm.nih.gov/pubmed/34947102 http://dx.doi.org/10.3390/ma14247502 |
work_keys_str_mv | AT tseregorodtsevapolinas singlefiberdiffusereflectancespectroscopyandspatialfrequencydomainimaginginsurgeryguidanceastudyonopticalphantoms AT buiankinkirille singlefiberdiffusereflectancespectroscopyandspatialfrequencydomainimaginginsurgeryguidanceastudyonopticalphantoms AT yakimovborisp singlefiberdiffusereflectancespectroscopyandspatialfrequencydomainimaginginsurgeryguidanceastudyonopticalphantoms AT kamalovarmaisa singlefiberdiffusereflectancespectroscopyandspatialfrequencydomainimaginginsurgeryguidanceastudyonopticalphantoms AT budylinglebs singlefiberdiffusereflectancespectroscopyandspatialfrequencydomainimaginginsurgeryguidanceastudyonopticalphantoms AT shirshinevgenya singlefiberdiffusereflectancespectroscopyandspatialfrequencydomainimaginginsurgeryguidanceastudyonopticalphantoms |