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Nanoformulations of α-Mangostin for Cancer Drug Delivery System

Natural compounds are emerging as effective agents for the treatment of malignant diseases. The active constituent of α-mangostin from the pericarp of Garcinia mangostana L. has earned significant interest as a plant base compound with anticancer properties. Despite α-mangostin’s superior properties...

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Autores principales: Meylina, Lisna, Muchtaridi, Muchtaridi, Joni, I Made, Mohammed, Ahmed Fouad Abdelwahab, Wathoni, Nasrul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708633/
https://www.ncbi.nlm.nih.gov/pubmed/34959275
http://dx.doi.org/10.3390/pharmaceutics13121993
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author Meylina, Lisna
Muchtaridi, Muchtaridi
Joni, I Made
Mohammed, Ahmed Fouad Abdelwahab
Wathoni, Nasrul
author_facet Meylina, Lisna
Muchtaridi, Muchtaridi
Joni, I Made
Mohammed, Ahmed Fouad Abdelwahab
Wathoni, Nasrul
author_sort Meylina, Lisna
collection PubMed
description Natural compounds are emerging as effective agents for the treatment of malignant diseases. The active constituent of α-mangostin from the pericarp of Garcinia mangostana L. has earned significant interest as a plant base compound with anticancer properties. Despite α-mangostin’s superior properties as an anticancer agent, its applications are limited due to its poor solubility and physicochemical stability, rapid systemic clearance, and low cellular uptake. Our review aimed to summarize and discuss the nanoparticle formulations of α-mangostin for cancer drug delivery systems from published papers recorded in Scopus, PubMed, and Google Scholar. We investigated various types of α-mangostin nanoformulations to improve its anticancer efficacy by improving bioavailability, cellular uptake, and localization to specific areas These nanoformulations include nanofibers, lipid carrier nanostructures, solid lipid nanoparticles, polymeric nanoparticles, nanomicelles, liposomes, and gold nanoparticles. Notably, polymeric nanoparticles and nanomicelles can increase the accumulation of α-mangostin into tumors and inhibit tumor growth in vivo. In addition, polymeric nanoparticles with the addition of target ligands can increase the cellular uptake of α-mangostin. In conclusion, nanoformulations of α-mangostin are a promising tool to enhance the cellular uptake, accumulation in cancer cells, and the efficacy of α-mangostin as a candidate for anticancer drugs.
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spelling pubmed-87086332021-12-25 Nanoformulations of α-Mangostin for Cancer Drug Delivery System Meylina, Lisna Muchtaridi, Muchtaridi Joni, I Made Mohammed, Ahmed Fouad Abdelwahab Wathoni, Nasrul Pharmaceutics Review Natural compounds are emerging as effective agents for the treatment of malignant diseases. The active constituent of α-mangostin from the pericarp of Garcinia mangostana L. has earned significant interest as a plant base compound with anticancer properties. Despite α-mangostin’s superior properties as an anticancer agent, its applications are limited due to its poor solubility and physicochemical stability, rapid systemic clearance, and low cellular uptake. Our review aimed to summarize and discuss the nanoparticle formulations of α-mangostin for cancer drug delivery systems from published papers recorded in Scopus, PubMed, and Google Scholar. We investigated various types of α-mangostin nanoformulations to improve its anticancer efficacy by improving bioavailability, cellular uptake, and localization to specific areas These nanoformulations include nanofibers, lipid carrier nanostructures, solid lipid nanoparticles, polymeric nanoparticles, nanomicelles, liposomes, and gold nanoparticles. Notably, polymeric nanoparticles and nanomicelles can increase the accumulation of α-mangostin into tumors and inhibit tumor growth in vivo. In addition, polymeric nanoparticles with the addition of target ligands can increase the cellular uptake of α-mangostin. In conclusion, nanoformulations of α-mangostin are a promising tool to enhance the cellular uptake, accumulation in cancer cells, and the efficacy of α-mangostin as a candidate for anticancer drugs. MDPI 2021-11-24 /pmc/articles/PMC8708633/ /pubmed/34959275 http://dx.doi.org/10.3390/pharmaceutics13121993 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Meylina, Lisna
Muchtaridi, Muchtaridi
Joni, I Made
Mohammed, Ahmed Fouad Abdelwahab
Wathoni, Nasrul
Nanoformulations of α-Mangostin for Cancer Drug Delivery System
title Nanoformulations of α-Mangostin for Cancer Drug Delivery System
title_full Nanoformulations of α-Mangostin for Cancer Drug Delivery System
title_fullStr Nanoformulations of α-Mangostin for Cancer Drug Delivery System
title_full_unstemmed Nanoformulations of α-Mangostin for Cancer Drug Delivery System
title_short Nanoformulations of α-Mangostin for Cancer Drug Delivery System
title_sort nanoformulations of α-mangostin for cancer drug delivery system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708633/
https://www.ncbi.nlm.nih.gov/pubmed/34959275
http://dx.doi.org/10.3390/pharmaceutics13121993
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