The Reciprocal Relationship between LDL Metabolism and Type 2 Diabetes Mellitus

Type 2 diabetes mellitus and insulin resistance feature substantial modifications of the lipoprotein profile, including a higher proportion of smaller and denser low-density lipoprotein (LDL) particles. In addition, qualitative changes occur in the composition and structure of LDL, including changes...

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Detalles Bibliográficos
Autores principales: Bonilha, Isabella, Hajduch, Eric, Luchiari, Beatriz, Nadruz, Wilson, Le Goff, Wilfried, Sposito, Andrei C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708656/
https://www.ncbi.nlm.nih.gov/pubmed/34940565
http://dx.doi.org/10.3390/metabo11120807
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author Bonilha, Isabella
Hajduch, Eric
Luchiari, Beatriz
Nadruz, Wilson
Le Goff, Wilfried
Sposito, Andrei C.
author_facet Bonilha, Isabella
Hajduch, Eric
Luchiari, Beatriz
Nadruz, Wilson
Le Goff, Wilfried
Sposito, Andrei C.
author_sort Bonilha, Isabella
collection PubMed
description Type 2 diabetes mellitus and insulin resistance feature substantial modifications of the lipoprotein profile, including a higher proportion of smaller and denser low-density lipoprotein (LDL) particles. In addition, qualitative changes occur in the composition and structure of LDL, including changes in electrophoretic mobility, enrichment of LDL with triglycerides and ceramides, prolonged retention of modified LDL in plasma, increased uptake by macrophages, and the formation of foam cells. These modifications affect LDL functions and favor an increased risk of cardiovascular disease in diabetic individuals. In this review, we discuss the main findings regarding the structural and functional changes in LDL particles in diabetes pathophysiology and therapeutic strategies targeting LDL in patients with diabetes.
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spelling pubmed-87086562021-12-25 The Reciprocal Relationship between LDL Metabolism and Type 2 Diabetes Mellitus Bonilha, Isabella Hajduch, Eric Luchiari, Beatriz Nadruz, Wilson Le Goff, Wilfried Sposito, Andrei C. Metabolites Review Type 2 diabetes mellitus and insulin resistance feature substantial modifications of the lipoprotein profile, including a higher proportion of smaller and denser low-density lipoprotein (LDL) particles. In addition, qualitative changes occur in the composition and structure of LDL, including changes in electrophoretic mobility, enrichment of LDL with triglycerides and ceramides, prolonged retention of modified LDL in plasma, increased uptake by macrophages, and the formation of foam cells. These modifications affect LDL functions and favor an increased risk of cardiovascular disease in diabetic individuals. In this review, we discuss the main findings regarding the structural and functional changes in LDL particles in diabetes pathophysiology and therapeutic strategies targeting LDL in patients with diabetes. MDPI 2021-11-28 /pmc/articles/PMC8708656/ /pubmed/34940565 http://dx.doi.org/10.3390/metabo11120807 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bonilha, Isabella
Hajduch, Eric
Luchiari, Beatriz
Nadruz, Wilson
Le Goff, Wilfried
Sposito, Andrei C.
The Reciprocal Relationship between LDL Metabolism and Type 2 Diabetes Mellitus
title The Reciprocal Relationship between LDL Metabolism and Type 2 Diabetes Mellitus
title_full The Reciprocal Relationship between LDL Metabolism and Type 2 Diabetes Mellitus
title_fullStr The Reciprocal Relationship between LDL Metabolism and Type 2 Diabetes Mellitus
title_full_unstemmed The Reciprocal Relationship between LDL Metabolism and Type 2 Diabetes Mellitus
title_short The Reciprocal Relationship between LDL Metabolism and Type 2 Diabetes Mellitus
title_sort reciprocal relationship between ldl metabolism and type 2 diabetes mellitus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708656/
https://www.ncbi.nlm.nih.gov/pubmed/34940565
http://dx.doi.org/10.3390/metabo11120807
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