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Teicoplanin—A New Use for an Old Drug in the COVID-19 Era?

Teicoplanin is an antibiotic that has been actively used in medical practice since 1986 to treat serious Gram-positive bacterial infections. Due to its efficiency and low cytotoxicity, teicoplanin has also been used for patients with complications, including pediatric and immunocompromised patients....

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Detalles Bibliográficos
Autor principal: Vimberg, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708781/
https://www.ncbi.nlm.nih.gov/pubmed/34959628
http://dx.doi.org/10.3390/ph14121227
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author Vimberg, Vladimir
author_facet Vimberg, Vladimir
author_sort Vimberg, Vladimir
collection PubMed
description Teicoplanin is an antibiotic that has been actively used in medical practice since 1986 to treat serious Gram-positive bacterial infections. Due to its efficiency and low cytotoxicity, teicoplanin has also been used for patients with complications, including pediatric and immunocompromised patients. Although teicoplanin is accepted as an antibacterial drug, its action against RNA viruses, including SARS-CoV2, has been proven in vitro. Here, we provide a thorough overview of teicoplanin usage in medicine, based on the current literature. We summarize infection sites treated with teicoplanin, concentrations of the antibiotic in different organs, and side effects. Finally, we summarize all available data about the antiviral activity of teicoplanin. We believe that, due to the extensive experience of teicoplanin usage in clinical settings to treat bacterial infections and its demonstrated activity against SARS-CoV2, teicoplanin could become a drug of choice in the treatment of COVID-19 patients. Teicoplanin stops the replication of the virus and at the same time avoids the development of Gram-positive bacterial co-infections.
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spelling pubmed-87087812021-12-25 Teicoplanin—A New Use for an Old Drug in the COVID-19 Era? Vimberg, Vladimir Pharmaceuticals (Basel) Review Teicoplanin is an antibiotic that has been actively used in medical practice since 1986 to treat serious Gram-positive bacterial infections. Due to its efficiency and low cytotoxicity, teicoplanin has also been used for patients with complications, including pediatric and immunocompromised patients. Although teicoplanin is accepted as an antibacterial drug, its action against RNA viruses, including SARS-CoV2, has been proven in vitro. Here, we provide a thorough overview of teicoplanin usage in medicine, based on the current literature. We summarize infection sites treated with teicoplanin, concentrations of the antibiotic in different organs, and side effects. Finally, we summarize all available data about the antiviral activity of teicoplanin. We believe that, due to the extensive experience of teicoplanin usage in clinical settings to treat bacterial infections and its demonstrated activity against SARS-CoV2, teicoplanin could become a drug of choice in the treatment of COVID-19 patients. Teicoplanin stops the replication of the virus and at the same time avoids the development of Gram-positive bacterial co-infections. MDPI 2021-11-26 /pmc/articles/PMC8708781/ /pubmed/34959628 http://dx.doi.org/10.3390/ph14121227 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Vimberg, Vladimir
Teicoplanin—A New Use for an Old Drug in the COVID-19 Era?
title Teicoplanin—A New Use for an Old Drug in the COVID-19 Era?
title_full Teicoplanin—A New Use for an Old Drug in the COVID-19 Era?
title_fullStr Teicoplanin—A New Use for an Old Drug in the COVID-19 Era?
title_full_unstemmed Teicoplanin—A New Use for an Old Drug in the COVID-19 Era?
title_short Teicoplanin—A New Use for an Old Drug in the COVID-19 Era?
title_sort teicoplanin—a new use for an old drug in the covid-19 era?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708781/
https://www.ncbi.nlm.nih.gov/pubmed/34959628
http://dx.doi.org/10.3390/ph14121227
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