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Headache Worsening after COVID-19 Vaccination: An Online Questionnaire-Based Study on 841 Patients with Migraine

Vaccines have represented the breakthrough in the fight against COVID-19. Based on reported headache attacks after vaccination in randomized controlled trials, we focused on the effects of COVID-19 vaccine administration on the migraine population, using an online questionnaire published on Italian...

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Autores principales: Silvestro, Marcello, Tessitore, Alessandro, Orologio, Ilaria, Sozio, Pasquale, Napolitano, Giuseppe, Siciliano, Mattia, Tedeschi, Gioacchino, Russo, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708794/
https://www.ncbi.nlm.nih.gov/pubmed/34945208
http://dx.doi.org/10.3390/jcm10245914
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author Silvestro, Marcello
Tessitore, Alessandro
Orologio, Ilaria
Sozio, Pasquale
Napolitano, Giuseppe
Siciliano, Mattia
Tedeschi, Gioacchino
Russo, Antonio
author_facet Silvestro, Marcello
Tessitore, Alessandro
Orologio, Ilaria
Sozio, Pasquale
Napolitano, Giuseppe
Siciliano, Mattia
Tedeschi, Gioacchino
Russo, Antonio
author_sort Silvestro, Marcello
collection PubMed
description Vaccines have represented the breakthrough in the fight against COVID-19. Based on reported headache attacks after vaccination in randomized controlled trials, we focused on the effects of COVID-19 vaccine administration on the migraine population, using an online questionnaire published on Italian Facebook groups oriented to headache patients. We collected data about the demographics and clinical parameters of migraine severity, COVID-19 infection, vaccination, and characteristics of headaches following vaccination. Out of 841 migraine patients filling in the questionnaire, 66.47% and 60.15% patients experienced a headache attack (from 1 hour to 7 days) after the first and the second vaccine dose, respectively. The main finding concerns headaches perceived by 57.60% of patients: attacks following vaccination were referred to as more severe (50.62% of patients), long-lasting (52.80% of patients) and hardwearing (49.69% of patients) compared to the usually experienced migraine attacks. This could be related to the production of inflammatory mediators such as type Iβ interferon. Considering the high prevalence of migraine in the general population, awareness of the possibility of headaches worsening following COVID-19 vaccination in these patients may allow both patients and clinicians to face this clinical entity with conscious serenity, and to reduce the waste of resources towards inappropriate health-care.
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spelling pubmed-87087942021-12-25 Headache Worsening after COVID-19 Vaccination: An Online Questionnaire-Based Study on 841 Patients with Migraine Silvestro, Marcello Tessitore, Alessandro Orologio, Ilaria Sozio, Pasquale Napolitano, Giuseppe Siciliano, Mattia Tedeschi, Gioacchino Russo, Antonio J Clin Med Article Vaccines have represented the breakthrough in the fight against COVID-19. Based on reported headache attacks after vaccination in randomized controlled trials, we focused on the effects of COVID-19 vaccine administration on the migraine population, using an online questionnaire published on Italian Facebook groups oriented to headache patients. We collected data about the demographics and clinical parameters of migraine severity, COVID-19 infection, vaccination, and characteristics of headaches following vaccination. Out of 841 migraine patients filling in the questionnaire, 66.47% and 60.15% patients experienced a headache attack (from 1 hour to 7 days) after the first and the second vaccine dose, respectively. The main finding concerns headaches perceived by 57.60% of patients: attacks following vaccination were referred to as more severe (50.62% of patients), long-lasting (52.80% of patients) and hardwearing (49.69% of patients) compared to the usually experienced migraine attacks. This could be related to the production of inflammatory mediators such as type Iβ interferon. Considering the high prevalence of migraine in the general population, awareness of the possibility of headaches worsening following COVID-19 vaccination in these patients may allow both patients and clinicians to face this clinical entity with conscious serenity, and to reduce the waste of resources towards inappropriate health-care. MDPI 2021-12-16 /pmc/articles/PMC8708794/ /pubmed/34945208 http://dx.doi.org/10.3390/jcm10245914 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Silvestro, Marcello
Tessitore, Alessandro
Orologio, Ilaria
Sozio, Pasquale
Napolitano, Giuseppe
Siciliano, Mattia
Tedeschi, Gioacchino
Russo, Antonio
Headache Worsening after COVID-19 Vaccination: An Online Questionnaire-Based Study on 841 Patients with Migraine
title Headache Worsening after COVID-19 Vaccination: An Online Questionnaire-Based Study on 841 Patients with Migraine
title_full Headache Worsening after COVID-19 Vaccination: An Online Questionnaire-Based Study on 841 Patients with Migraine
title_fullStr Headache Worsening after COVID-19 Vaccination: An Online Questionnaire-Based Study on 841 Patients with Migraine
title_full_unstemmed Headache Worsening after COVID-19 Vaccination: An Online Questionnaire-Based Study on 841 Patients with Migraine
title_short Headache Worsening after COVID-19 Vaccination: An Online Questionnaire-Based Study on 841 Patients with Migraine
title_sort headache worsening after covid-19 vaccination: an online questionnaire-based study on 841 patients with migraine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708794/
https://www.ncbi.nlm.nih.gov/pubmed/34945208
http://dx.doi.org/10.3390/jcm10245914
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