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Polymer Micro and Nanoparticles Containing B(III) Compounds as Emissive Soft Materials for Cargo Encapsulation and Temperature-Dependent Applications

Polymer nanoparticles doped with fluorescent molecules are widely applied for biological assays, local temperature measurements, and other bioimaging applications, overcoming several critical drawbacks, such as dye toxicity, increased water solubility, and allowing imaging of dyes/drug delivery in w...

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Autores principales: Duarte, Frederico, Cuerva, Cristián, Fernández-Lodeiro, Carlos, Fernández-Lodeiro, Javier, Jiménez, Raquel, Cano, Mercedes, Lodeiro, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708886/
https://www.ncbi.nlm.nih.gov/pubmed/34947786
http://dx.doi.org/10.3390/nano11123437
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author Duarte, Frederico
Cuerva, Cristián
Fernández-Lodeiro, Carlos
Fernández-Lodeiro, Javier
Jiménez, Raquel
Cano, Mercedes
Lodeiro, Carlos
author_facet Duarte, Frederico
Cuerva, Cristián
Fernández-Lodeiro, Carlos
Fernández-Lodeiro, Javier
Jiménez, Raquel
Cano, Mercedes
Lodeiro, Carlos
author_sort Duarte, Frederico
collection PubMed
description Polymer nanoparticles doped with fluorescent molecules are widely applied for biological assays, local temperature measurements, and other bioimaging applications, overcoming several critical drawbacks, such as dye toxicity, increased water solubility, and allowing imaging of dyes/drug delivery in water. In this work, some polymethylmethacrylate (PMMA), polyvinylpyrrolidone (PVP) and poly(styrene-butadiene-styrene) (SBS) based micro and nanoparticles with an average size of about 200 nm and encapsulating B(III) compounds have been prepared via the reprecipitation method by using tetrahydrofuran as the oil phase and water. The compounds are highly hydrophobic, but their encapsulation into a polymer matrix allows obtaining stable colloidal dispersions in water (3.39 µM) that maintain the photophysical behavior of these dyes. Although thermally activated non-radiative processes occur by increasing temperature from 25 to 80 °C, the colloidal suspension of the B(III) particles continues to emit greenish light (λ = 509 nm) at high temperatures. When samples are cooling back to room temperature, the emission is restored, being reversible. A probe of concept drug delivery study was conducted using coumarin 6 as a prototype of a hydrophobic drug.
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spelling pubmed-87088862021-12-25 Polymer Micro and Nanoparticles Containing B(III) Compounds as Emissive Soft Materials for Cargo Encapsulation and Temperature-Dependent Applications Duarte, Frederico Cuerva, Cristián Fernández-Lodeiro, Carlos Fernández-Lodeiro, Javier Jiménez, Raquel Cano, Mercedes Lodeiro, Carlos Nanomaterials (Basel) Article Polymer nanoparticles doped with fluorescent molecules are widely applied for biological assays, local temperature measurements, and other bioimaging applications, overcoming several critical drawbacks, such as dye toxicity, increased water solubility, and allowing imaging of dyes/drug delivery in water. In this work, some polymethylmethacrylate (PMMA), polyvinylpyrrolidone (PVP) and poly(styrene-butadiene-styrene) (SBS) based micro and nanoparticles with an average size of about 200 nm and encapsulating B(III) compounds have been prepared via the reprecipitation method by using tetrahydrofuran as the oil phase and water. The compounds are highly hydrophobic, but their encapsulation into a polymer matrix allows obtaining stable colloidal dispersions in water (3.39 µM) that maintain the photophysical behavior of these dyes. Although thermally activated non-radiative processes occur by increasing temperature from 25 to 80 °C, the colloidal suspension of the B(III) particles continues to emit greenish light (λ = 509 nm) at high temperatures. When samples are cooling back to room temperature, the emission is restored, being reversible. A probe of concept drug delivery study was conducted using coumarin 6 as a prototype of a hydrophobic drug. MDPI 2021-12-18 /pmc/articles/PMC8708886/ /pubmed/34947786 http://dx.doi.org/10.3390/nano11123437 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Duarte, Frederico
Cuerva, Cristián
Fernández-Lodeiro, Carlos
Fernández-Lodeiro, Javier
Jiménez, Raquel
Cano, Mercedes
Lodeiro, Carlos
Polymer Micro and Nanoparticles Containing B(III) Compounds as Emissive Soft Materials for Cargo Encapsulation and Temperature-Dependent Applications
title Polymer Micro and Nanoparticles Containing B(III) Compounds as Emissive Soft Materials for Cargo Encapsulation and Temperature-Dependent Applications
title_full Polymer Micro and Nanoparticles Containing B(III) Compounds as Emissive Soft Materials for Cargo Encapsulation and Temperature-Dependent Applications
title_fullStr Polymer Micro and Nanoparticles Containing B(III) Compounds as Emissive Soft Materials for Cargo Encapsulation and Temperature-Dependent Applications
title_full_unstemmed Polymer Micro and Nanoparticles Containing B(III) Compounds as Emissive Soft Materials for Cargo Encapsulation and Temperature-Dependent Applications
title_short Polymer Micro and Nanoparticles Containing B(III) Compounds as Emissive Soft Materials for Cargo Encapsulation and Temperature-Dependent Applications
title_sort polymer micro and nanoparticles containing b(iii) compounds as emissive soft materials for cargo encapsulation and temperature-dependent applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708886/
https://www.ncbi.nlm.nih.gov/pubmed/34947786
http://dx.doi.org/10.3390/nano11123437
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