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sTREM-1 Predicts Disease Severity and Mortality in COVID-19 Patients: Involvement of Peripheral Blood Leukocytes and MMP-8 Activity

Uncontrolled inflammatory responses play a critical role in coronavirus disease (COVID-19). In this context, because the triggering-receptor expressed on myeloid cells-1 (TREM-1) is considered an intrinsic amplifier of inflammatory signals, this study investigated the role of soluble TREM-1 (sTREM-1...

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Autores principales: da Silva-Neto, Pedro V., de Carvalho, Jonatan C. S., Pimentel, Vinícius E., Pérez, Malena M., Toro, Diana M., Fraga-Silva, Thais F. C., Fuzo, Carlos A., Oliveira, Camilla N. S., Rodrigues, Lilian C., Argolo, Jamille G. M., Carmona-Garcia, Ingryd, Neto, Nicola T., Souza, Camila O. S., Fernandes, Talita M., Bastos, Victor A. F., Degiovani, Augusto M., Constant, Leticia F., Ostini, Fátima M., Feitosa, Marley R., Parra, Rogerio S., Vilar, Fernando C., Gaspar, Gilberto G., da Rocha, José J. R., Feres, Omar, Frantz, Fabiani G., Gerlach, Raquel F., Maruyama, Sandra R., Russo, Elisa M. S., Viana, Angelina L., Fernandes, Ana P. M., Santos, Isabel K. F. M., Bonato, Vânia L. D., Boechat, Antonio L., Malheiro, Adriana, Sadikot, Ruxana T., Dias-Baruffi, Marcelo, Cardoso, Cristina R. B., Faccioli, Lúcia H., Sorgi, Carlos A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708887/
https://www.ncbi.nlm.nih.gov/pubmed/34960790
http://dx.doi.org/10.3390/v13122521
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author da Silva-Neto, Pedro V.
de Carvalho, Jonatan C. S.
Pimentel, Vinícius E.
Pérez, Malena M.
Toro, Diana M.
Fraga-Silva, Thais F. C.
Fuzo, Carlos A.
Oliveira, Camilla N. S.
Rodrigues, Lilian C.
Argolo, Jamille G. M.
Carmona-Garcia, Ingryd
Neto, Nicola T.
Souza, Camila O. S.
Fernandes, Talita M.
Bastos, Victor A. F.
Degiovani, Augusto M.
Constant, Leticia F.
Ostini, Fátima M.
Feitosa, Marley R.
Parra, Rogerio S.
Vilar, Fernando C.
Gaspar, Gilberto G.
da Rocha, José J. R.
Feres, Omar
Frantz, Fabiani G.
Gerlach, Raquel F.
Maruyama, Sandra R.
Russo, Elisa M. S.
Viana, Angelina L.
Fernandes, Ana P. M.
Santos, Isabel K. F. M.
Bonato, Vânia L. D.
Boechat, Antonio L.
Malheiro, Adriana
Sadikot, Ruxana T.
Dias-Baruffi, Marcelo
Cardoso, Cristina R. B.
Faccioli, Lúcia H.
Sorgi, Carlos A.
author_facet da Silva-Neto, Pedro V.
de Carvalho, Jonatan C. S.
Pimentel, Vinícius E.
Pérez, Malena M.
Toro, Diana M.
Fraga-Silva, Thais F. C.
Fuzo, Carlos A.
Oliveira, Camilla N. S.
Rodrigues, Lilian C.
Argolo, Jamille G. M.
Carmona-Garcia, Ingryd
Neto, Nicola T.
Souza, Camila O. S.
Fernandes, Talita M.
Bastos, Victor A. F.
Degiovani, Augusto M.
Constant, Leticia F.
Ostini, Fátima M.
Feitosa, Marley R.
Parra, Rogerio S.
Vilar, Fernando C.
Gaspar, Gilberto G.
da Rocha, José J. R.
Feres, Omar
Frantz, Fabiani G.
Gerlach, Raquel F.
Maruyama, Sandra R.
Russo, Elisa M. S.
Viana, Angelina L.
Fernandes, Ana P. M.
Santos, Isabel K. F. M.
Bonato, Vânia L. D.
Boechat, Antonio L.
Malheiro, Adriana
Sadikot, Ruxana T.
Dias-Baruffi, Marcelo
Cardoso, Cristina R. B.
Faccioli, Lúcia H.
Sorgi, Carlos A.
author_sort da Silva-Neto, Pedro V.
collection PubMed
description Uncontrolled inflammatory responses play a critical role in coronavirus disease (COVID-19). In this context, because the triggering-receptor expressed on myeloid cells-1 (TREM-1) is considered an intrinsic amplifier of inflammatory signals, this study investigated the role of soluble TREM-1 (sTREM-1) as a biomarker of the severity and mortality of COVID-19. Based on their clinical scores, we enrolled COVID-19 positive patients (n = 237) classified into mild, moderate, severe, and critical groups. Clinical data and patient characteristics were obtained from medical records, and their plasma inflammatory mediator profiles were evaluated with immunoassays. Plasma levels of sTREM-1 were significantly higher among patients with severe disease compared to all other groups. Additionally, levels of sTREM-1 showed a significant positive correlation with other inflammatory parameters, such as IL-6, IL-10, IL-8, and neutrophil counts, and a significant negative correlation was observed with lymphocyte counts. Most interestingly, sTREM-1 was found to be a strong predictive biomarker of the severity of COVID-19 and was related to the worst outcome and death. Systemic levels of sTREM-1 were significantly correlated with the expression of matrix metalloproteinases (MMP)-8, which can release TREM-1 from the surface of peripheral blood cells. Our findings indicated that quantification of sTREM-1 could be used as a predictive tool for disease outcome, thus improving the timing of clinical and pharmacological interventions in patients with COVID-19.
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spelling pubmed-87088872021-12-25 sTREM-1 Predicts Disease Severity and Mortality in COVID-19 Patients: Involvement of Peripheral Blood Leukocytes and MMP-8 Activity da Silva-Neto, Pedro V. de Carvalho, Jonatan C. S. Pimentel, Vinícius E. Pérez, Malena M. Toro, Diana M. Fraga-Silva, Thais F. C. Fuzo, Carlos A. Oliveira, Camilla N. S. Rodrigues, Lilian C. Argolo, Jamille G. M. Carmona-Garcia, Ingryd Neto, Nicola T. Souza, Camila O. S. Fernandes, Talita M. Bastos, Victor A. F. Degiovani, Augusto M. Constant, Leticia F. Ostini, Fátima M. Feitosa, Marley R. Parra, Rogerio S. Vilar, Fernando C. Gaspar, Gilberto G. da Rocha, José J. R. Feres, Omar Frantz, Fabiani G. Gerlach, Raquel F. Maruyama, Sandra R. Russo, Elisa M. S. Viana, Angelina L. Fernandes, Ana P. M. Santos, Isabel K. F. M. Bonato, Vânia L. D. Boechat, Antonio L. Malheiro, Adriana Sadikot, Ruxana T. Dias-Baruffi, Marcelo Cardoso, Cristina R. B. Faccioli, Lúcia H. Sorgi, Carlos A. Viruses Article Uncontrolled inflammatory responses play a critical role in coronavirus disease (COVID-19). In this context, because the triggering-receptor expressed on myeloid cells-1 (TREM-1) is considered an intrinsic amplifier of inflammatory signals, this study investigated the role of soluble TREM-1 (sTREM-1) as a biomarker of the severity and mortality of COVID-19. Based on their clinical scores, we enrolled COVID-19 positive patients (n = 237) classified into mild, moderate, severe, and critical groups. Clinical data and patient characteristics were obtained from medical records, and their plasma inflammatory mediator profiles were evaluated with immunoassays. Plasma levels of sTREM-1 were significantly higher among patients with severe disease compared to all other groups. Additionally, levels of sTREM-1 showed a significant positive correlation with other inflammatory parameters, such as IL-6, IL-10, IL-8, and neutrophil counts, and a significant negative correlation was observed with lymphocyte counts. Most interestingly, sTREM-1 was found to be a strong predictive biomarker of the severity of COVID-19 and was related to the worst outcome and death. Systemic levels of sTREM-1 were significantly correlated with the expression of matrix metalloproteinases (MMP)-8, which can release TREM-1 from the surface of peripheral blood cells. Our findings indicated that quantification of sTREM-1 could be used as a predictive tool for disease outcome, thus improving the timing of clinical and pharmacological interventions in patients with COVID-19. MDPI 2021-12-15 /pmc/articles/PMC8708887/ /pubmed/34960790 http://dx.doi.org/10.3390/v13122521 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
da Silva-Neto, Pedro V.
de Carvalho, Jonatan C. S.
Pimentel, Vinícius E.
Pérez, Malena M.
Toro, Diana M.
Fraga-Silva, Thais F. C.
Fuzo, Carlos A.
Oliveira, Camilla N. S.
Rodrigues, Lilian C.
Argolo, Jamille G. M.
Carmona-Garcia, Ingryd
Neto, Nicola T.
Souza, Camila O. S.
Fernandes, Talita M.
Bastos, Victor A. F.
Degiovani, Augusto M.
Constant, Leticia F.
Ostini, Fátima M.
Feitosa, Marley R.
Parra, Rogerio S.
Vilar, Fernando C.
Gaspar, Gilberto G.
da Rocha, José J. R.
Feres, Omar
Frantz, Fabiani G.
Gerlach, Raquel F.
Maruyama, Sandra R.
Russo, Elisa M. S.
Viana, Angelina L.
Fernandes, Ana P. M.
Santos, Isabel K. F. M.
Bonato, Vânia L. D.
Boechat, Antonio L.
Malheiro, Adriana
Sadikot, Ruxana T.
Dias-Baruffi, Marcelo
Cardoso, Cristina R. B.
Faccioli, Lúcia H.
Sorgi, Carlos A.
sTREM-1 Predicts Disease Severity and Mortality in COVID-19 Patients: Involvement of Peripheral Blood Leukocytes and MMP-8 Activity
title sTREM-1 Predicts Disease Severity and Mortality in COVID-19 Patients: Involvement of Peripheral Blood Leukocytes and MMP-8 Activity
title_full sTREM-1 Predicts Disease Severity and Mortality in COVID-19 Patients: Involvement of Peripheral Blood Leukocytes and MMP-8 Activity
title_fullStr sTREM-1 Predicts Disease Severity and Mortality in COVID-19 Patients: Involvement of Peripheral Blood Leukocytes and MMP-8 Activity
title_full_unstemmed sTREM-1 Predicts Disease Severity and Mortality in COVID-19 Patients: Involvement of Peripheral Blood Leukocytes and MMP-8 Activity
title_short sTREM-1 Predicts Disease Severity and Mortality in COVID-19 Patients: Involvement of Peripheral Blood Leukocytes and MMP-8 Activity
title_sort strem-1 predicts disease severity and mortality in covid-19 patients: involvement of peripheral blood leukocytes and mmp-8 activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708887/
https://www.ncbi.nlm.nih.gov/pubmed/34960790
http://dx.doi.org/10.3390/v13122521
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