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Questionnaire Survey of Possible Association of Allergic Diseases with Adverse Reactions to SARS-CoV-2 Vaccination

To protect against COVID-19, SARS-CoV-2 vaccines have been widely used. Besides anaphylaxis, some less severe adverse effects may occur at higher frequencies. It remains unclear whether present or past histories of allergic diseases exert effects on local and systemic reactions. We conducted a quest...

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Autores principales: Morimoto, Hiroki, Hayano, Satoshi, Ozawa, Naoya, Ogura, Yasuaki, Usui, Hiroaki, Usami, Takahiro, Ohse, Ayako, Otsuka, Masaki, Miyachi, Masahiko, Tokura, Yoshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708946/
https://www.ncbi.nlm.nih.gov/pubmed/34960167
http://dx.doi.org/10.3390/vaccines9121421
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author Morimoto, Hiroki
Hayano, Satoshi
Ozawa, Naoya
Ogura, Yasuaki
Usui, Hiroaki
Usami, Takahiro
Ohse, Ayako
Otsuka, Masaki
Miyachi, Masahiko
Tokura, Yoshiki
author_facet Morimoto, Hiroki
Hayano, Satoshi
Ozawa, Naoya
Ogura, Yasuaki
Usui, Hiroaki
Usami, Takahiro
Ohse, Ayako
Otsuka, Masaki
Miyachi, Masahiko
Tokura, Yoshiki
author_sort Morimoto, Hiroki
collection PubMed
description To protect against COVID-19, SARS-CoV-2 vaccines have been widely used. Besides anaphylaxis, some less severe adverse effects may occur at higher frequencies. It remains unclear whether present or past histories of allergic diseases exert effects on local and systemic reactions. We conducted a questionnaire survey among workers in our hospital. We analyzed the adverse effects occurring after the first and second doses of the Pfizer–BioNTech vaccine in 955 subjects. The presence or absence of local injection reactions and systemic reactions (headache, fatigability, fever, muscle pain, and joint pain) was questioned. The intensities of these reactions were graded on a scale of 0–4 (except fever) or 0–2 (fever). The allergic diseases that we focused on were bronchial asthma, atopic dermatitis, food allergy, pollinosis, and hand eczema. For the systemic reactions, fatigability after the first dose tended to be more severe in the bronchial asthma than in the non-allergic group. Headache, joint pain, and fever tended to be more severe in the food allergy than in the non-allergic group after the second dose. For the local skin reactions, atopic dermatitis subjects tended to show rather less severe local skin reactions after the second dose. The results contribute to the guidelines for the care of individuals with different allergy histories, so that they may safely receive their vaccine.
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spelling pubmed-87089462021-12-25 Questionnaire Survey of Possible Association of Allergic Diseases with Adverse Reactions to SARS-CoV-2 Vaccination Morimoto, Hiroki Hayano, Satoshi Ozawa, Naoya Ogura, Yasuaki Usui, Hiroaki Usami, Takahiro Ohse, Ayako Otsuka, Masaki Miyachi, Masahiko Tokura, Yoshiki Vaccines (Basel) Article To protect against COVID-19, SARS-CoV-2 vaccines have been widely used. Besides anaphylaxis, some less severe adverse effects may occur at higher frequencies. It remains unclear whether present or past histories of allergic diseases exert effects on local and systemic reactions. We conducted a questionnaire survey among workers in our hospital. We analyzed the adverse effects occurring after the first and second doses of the Pfizer–BioNTech vaccine in 955 subjects. The presence or absence of local injection reactions and systemic reactions (headache, fatigability, fever, muscle pain, and joint pain) was questioned. The intensities of these reactions were graded on a scale of 0–4 (except fever) or 0–2 (fever). The allergic diseases that we focused on were bronchial asthma, atopic dermatitis, food allergy, pollinosis, and hand eczema. For the systemic reactions, fatigability after the first dose tended to be more severe in the bronchial asthma than in the non-allergic group. Headache, joint pain, and fever tended to be more severe in the food allergy than in the non-allergic group after the second dose. For the local skin reactions, atopic dermatitis subjects tended to show rather less severe local skin reactions after the second dose. The results contribute to the guidelines for the care of individuals with different allergy histories, so that they may safely receive their vaccine. MDPI 2021-12-01 /pmc/articles/PMC8708946/ /pubmed/34960167 http://dx.doi.org/10.3390/vaccines9121421 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Morimoto, Hiroki
Hayano, Satoshi
Ozawa, Naoya
Ogura, Yasuaki
Usui, Hiroaki
Usami, Takahiro
Ohse, Ayako
Otsuka, Masaki
Miyachi, Masahiko
Tokura, Yoshiki
Questionnaire Survey of Possible Association of Allergic Diseases with Adverse Reactions to SARS-CoV-2 Vaccination
title Questionnaire Survey of Possible Association of Allergic Diseases with Adverse Reactions to SARS-CoV-2 Vaccination
title_full Questionnaire Survey of Possible Association of Allergic Diseases with Adverse Reactions to SARS-CoV-2 Vaccination
title_fullStr Questionnaire Survey of Possible Association of Allergic Diseases with Adverse Reactions to SARS-CoV-2 Vaccination
title_full_unstemmed Questionnaire Survey of Possible Association of Allergic Diseases with Adverse Reactions to SARS-CoV-2 Vaccination
title_short Questionnaire Survey of Possible Association of Allergic Diseases with Adverse Reactions to SARS-CoV-2 Vaccination
title_sort questionnaire survey of possible association of allergic diseases with adverse reactions to sars-cov-2 vaccination
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708946/
https://www.ncbi.nlm.nih.gov/pubmed/34960167
http://dx.doi.org/10.3390/vaccines9121421
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