Cargando…

Exploring Chemical Diversity of Phorbas Sponges as a Source of Novel Lead Compounds in Drug Discovery

Porifera, commonly referred to as marine sponges, are acknowledged as major producers of marine natural products (MNPs). Sponges of the genus Phorbas have attracted much attention over the years. They are widespread in all continents, and several structurally unique compounds have been identified fr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Caso, Alessia, da Silva, Fernanda Barbosa, Esposito, Germana, Teta, Roberta, Sala, Gerardo Della, Cavalcanti, Laura P. A. Nunes, Valverde, Alessandra Leda, Martins, Roberto Carlos C., Costantino, Valeria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708981/ https://www.ncbi.nlm.nih.gov/pubmed/34940666 http://dx.doi.org/10.3390/md19120667

Ejemplares similares

Isolation of Smenopyrone, a Bis-γ-Pyrone Polypropionate from the Caribbean Sponge Smenospongia aurea
por: Esposito, Germana, et al.
Publicado: (2018)

Zeamide, a Glycosylinositol Phosphorylceramide with the Novel Core Arap(1β→6)Ins Motif from the Marine Sponge Svenzea zeai
por: Della Sala, Gerardo, et al.
Publicado: (2017)

Fast Detection of Two Smenamide Family Members Using Molecular Networking
por: Caso, Alessia, et al.
Publicado: (2019)

Polyketide Synthases in the Microbiome of the Marine Sponge Plakortis halichondrioides: A Metagenomic Update
por: Della Sala, Gerardo, et al.
Publicado: (2014)

Isolation and Assessment of the in Vitro Anti-Tumor Activity of Smenothiazole A and B, Chlorinated Thiazole-Containing Peptide/Polyketides from the Caribbean Sponge, Smenospongia aurea
por: Esposito, Germana, et al.
Publicado: (2015)

Identification of Quorum Sensing Activators and Inhibitors in The Marine Sponge Sarcotragus spinosulus
por: Saurav, Kumar, et al.
Publicado: (2020)

Identification of the Biosynthetic Gene Cluster of Thermoactinoamides and Discovery of New Congeners by Integrated Genome Mining and MS-Based Molecular Networking
por: Della Sala, Gerardo, et al.
Publicado: (2020)

Smenamides A and B, Chlorinated Peptide/Polyketide Hybrids Containing a Dolapyrrolidinone Unit from the Caribbean Sponge Smenospongia aurea. Evaluation of Their Role as Leads in Antitumor Drug Research
por: Teta, Roberta, et al.
Publicado: (2013)

Chalinulasterol, a Chlorinated Steroid Disulfate from the Caribbean Sponge Chalinula molitba. Evaluation of Its Role as PXR Receptor Modulator
por: Teta, Roberta, et al.
Publicado: (2012)

Polyketide genes in the marine sponge Plakortis simplex: a new group of mono-modular type I polyketide synthases from sponge symbionts
por: Della Sala, Gerardo, et al.
Publicado: (2013)

Plakofuranolactone as a Quorum Quenching Agent from the Indonesian Sponge Plakortis cf. lita
por: Costantino, Valeria, et al.
Publicado: (2017)

New Tricks with an Old Sponge: Feature-Based Molecular Networking Led to Fast Identification of New Stylissamide L from Stylissa caribica
por: Scarpato, Silvia, et al.
Publicado: (2020)

Antibiofilm Activity of Phorbaketals from the Marine Sponge Phorbas sp. against Staphylococcus aureus
por: Kim, Yong-Guy, et al.
Publicado: (2021)

Anticancer Activity of Gukulenin A Isolated from the Marine Sponge Phorbas gukhulensis In Vitro and In Vivo
por: Ahn, Ji-Hye, et al.
Publicado: (2019)

Monitoring Cyanobacterial Blooms during the COVID-19 Pandemic in Campania, Italy: The Case of Lake Avernus
por: Teta, Roberta, et al.
Publicado: (2021)

Novel Insights in the Potential of Halogenated Polyketide–Peptide Molecules as Lead Compounds in Cancer Drug Discovery
por: Pellicioni, Valentina, et al.
Publicado: (2023)

Reproductive strategies of two common sympatric Mediterranean sponges: Dysidea avara (Dictyoceratida) and Phorbas tenacior (Poecilosclerida)
por: de Caralt, Sonia, et al.
Publicado: (2018)

Computational Metabolomics Tools Reveal Subarmigerides, Unprecedented Linear Peptides from the Marine Sponge Holobiont Callyspongia subarmigera
por: Castaldi, Andrea, et al.
Publicado: (2022)

A Four-Step Platform to Optimize Growth Conditions for High-Yield Production of Siderophores in Cyanobacteria
por: Kundu, Karishma, et al.
Publicado: (2023)

Molecular Docking and Biophysical Studies for Antiproliferative Assessment of Synthetic Pyrazolo-Pyrimidinones Tethered with Hydrazide-Hydrazones
por: Horchani, Mabrouk, et al.
Publicado: (2021)

Evaluating the Effects of an Organic Extract from the Mediterranean Sponge Geodia cydonium on Human Breast Cancer Cell Lines
por: Costantini, Susan, et al.
Publicado: (2017)

A Glimpse at Siderophores Production by Anabaena flos-aquae UTEX 1444
por: Teta, Roberta, et al.
Publicado: (2022)

Anti-Melanogenic Activity of Gagunin D, a Highly Oxygenated Diterpenoid from the Marine Sponge Phorbas sp., via Modulating Tyrosinase Expression and Degradation
por: Lee, Ho Yeon, et al.
Publicado: (2016)

Molecular Networking Revealed Unique UV-Absorbing Phospholipids: Favilipids from the Marine Sponge Clathria faviformis
por: Scarpato, Silvia, et al.
Publicado: (2023)

Discovery of Unusual Cyanobacterial Tryptophan-Containing Anabaenopeptins by MS/MS-Based Molecular Networking
por: Saha, Subhasish, et al.
Publicado: (2020)

Smenamide A Analogues. Synthesis and Biological Activity on Multiple Myeloma Cells
por: Caso, Alessia, et al.
Publicado: (2018)

Cytotoxicity of Endoperoxides from the Caribbean Sponge Plakortis halichondrioides towards Sensitive and Multidrug-Resistant Leukemia Cells: Acids vs. Esters Activity Evaluation
por: Schirmeister, Tanja, et al.
Publicado: (2017)

Phorbaketal A, Isolated from the Marine Sponge Phorbas sp., Exerts Its Anti-Inflammatory Effects via NF-κB Inhibition and Heme Oxygenase-1 Activation in Lipopolysaccharide-Stimulated Macrophages
por: Seo, Yun-Ji, et al.
Publicado: (2015)

A Collection of Bioactive Nitrogen-Containing Molecules from the Marine Sponge Acanthostrongylophora ingens
por: Esposito, Germana, et al.
Publicado: (2019)

Clogging the Ubiquitin-Proteasome Machinery with Marine Natural Products: Last Decade Update
por: Della Sala, Gerardo, et al.
Publicado: (2018)

Studies toward the Synthesis of Smenamide A, an Antiproliferative Metabolite from Smenospongia aurea: Total Synthesis of ent-Smenamide A and 16-epi-Smenamide A
por: Caso, Alessia, et al.
Publicado: (2017)

Fatty Acid Substitutions Modulate the Cytotoxicity of Puwainaphycins/Minutissamides Isolated from the Baltic Sea Cyanobacterium Nodularia harveyana UHCC-0300
por: Saurav, Kumar, et al.
Publicado: (2022)

In Situ Natural Product Discovery via an Artificial Marine Sponge
por: La Clair, James J., et al.
Publicado: (2014)

Metagenomic discovery of polybrominated diphenyl ether biosynthesis by marine sponges
por: Agarwal, Vinayak, et al.
Publicado: (2017)

In Search of Alternative Antibiotic Drugs: Quorum-Quenching Activity in Sponges and their Bacterial Isolates
por: Saurav, Kumar, et al.
Publicado: (2016)

Sponges and Their Symbionts as a Source of Valuable Compounds in Cosmeceutical Field
por: Esposito, Roberta, et al.
Publicado: (2021)

Microbial diversity in Mediterranean sponges as revealed by metataxonomic analysis
por: Ruocco, Nadia, et al.
Publicado: (2021)

The Understanding of the Metazoan Skeletal System, Based on the Initial Discoveries with Siliceous and Calcareous Sponges
por: Müller, Werner E. G., et al.
Publicado: (2017)

Evaluation of Marine Brown Algae and Sponges from Brazil as Anticoagulant and Antiplatelet Products
por: de Andrade Moura, Laura, et al.
Publicado: (2011)

Isolation, Genomic and Metabolomic Characterization of Streptomyces tendae VITAKN with Quorum Sensing Inhibitory Activity from Southern India
por: Ishaque, Nabila Mohammed, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_d3n902h6u211hm71frd1pqmnf4