Cargando…

Recent Advancements in the Development of Anti-Breast Cancer Synthetic Small Molecules

Among all cancer types, breast cancer (BC) still stands as one of the most serious diseases responsible for a large number of cancer-associated deaths among women worldwide, and diagnosed cases are increasing year by year worldwide. For a very long time, hormonal therapy, surgery, chemotherapy, and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Elkaeed, Eslam B., Salam, Hayam A. Abd El, Sabt, Ahmed, Al-Ansary, Ghada H., Eldehna, Wagdy M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709016/ https://www.ncbi.nlm.nih.gov/pubmed/34946704 http://dx.doi.org/10.3390/molecules26247611

Ejemplares similares

An updated review of fatty acid residue-tethered heterocyclic compounds: synthetic strategies and biological significance
por: Majrashi, Taghreed A., et al.
Publicado: (2023)

Development of 3-methyl/3-(morpholinomethyl)benzofuran derivatives as novel antitumor agents towards non-small cell lung cancer cells
por: Al-Sanea, Mohammad M., et al.
Publicado: (2021)

Olive Leaves as a Potential Phytotherapy in the Treatment of COVID-19 Disease; A Mini-Review
por: Abdelgawad, Shimaa M., et al.
Publicado: (2022)

Synthesis, Crystal Study, and Anti-Proliferative Activity of Some 2-Benzimidazolylthioacetophenones towards Triple-Negative Breast Cancer MDA-MB-468 Cells as Apoptosis-Inducing Agents
por: Abdel-Aziz, Hatem A., et al.
Publicado: (2016)

Marine-Inspired Bis-indoles Possessing Antiproliferative Activity against Breast Cancer; Design, Synthesis, and Biological Evaluation
por: Eldehna, Wagdy M., et al.
Publicado: (2020)

Identification of 3-(piperazinylmethyl)benzofuran derivatives as novel type II CDK2 inhibitors: design, synthesis, biological evaluation, and in silico insights
por: Eldehna, Wagdy M., et al.
Publicado: (2022)

Design, synthesis, anti-proliferative evaluation, docking, and MD simulations studies of new thiazolidine-2,4-diones targeting VEGFR-2 and apoptosis pathway
por: Taghour, Mohammed S., et al.
Publicado: (2022)

Novel [(3-indolylmethylene)hydrazono]indolin-2-ones as apoptotic anti-proliferative agents: design, synthesis and in vitro biological evaluation
por: Eldehna, Wagdy M., et al.
Publicado: (2018)

Anti-cancer and immunomodulatory evaluation of new nicotinamide derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: in vitro and in silico studies
por: Yousef, Reda G., et al.
Publicado: (2022)

New quinoline and isatin derivatives as apoptotic VEGFR-2 inhibitors: design, synthesis, anti-proliferative activity, docking, ADMET, toxicity, and MD simulation studies
por: Elkaeed, Eslam B., et al.
Publicado: (2022)

Multi-stage structure-based virtual screening approach towards identification of potential SARS-CoV-2 NSP13 helicase inhibitors
por: El Hassab, Mahmoud A., et al.
Publicado: (2022)

Synthesis and in vitro anti-proliferative activity of some novel isatins conjugated with quinazoline/phthalazine hydrazines against triple-negative breast cancer MDA-MB-231 cells as apoptosis-inducing agents
por: Eldehna, Wagdy M., et al.
Publicado: (2017)

Discovery of New VEGFR-2 Inhibitors: Design, Synthesis, Anti-Proliferative Evaluation, Docking, and MD Simulation Studies
por: Elkaeed, Eslam B., et al.
Publicado: (2022)

Discovery of new nicotinamides as apoptotic VEGFR-2 inhibitors: virtual screening, synthesis, anti-proliferative, immunomodulatory, ADMET, toxicity, and molecular dynamic simulation studies
por: Yousef, Reda G., et al.
Publicado: (2022)

2-Arylquinolines as novel anticancer agents with dual EGFR/FAK kinase inhibitory activity: synthesis, biological evaluation, and molecular modelling insights
por: Elbadawi, Mostafa M., et al.
Publicado: (2021)

Synthesis, Biological Evaluation and In Silico Studies of Certain Oxindole–Indole Conjugates as Anticancer CDK Inhibitors
por: Al-Warhi, Tarfah, et al.
Publicado: (2020)

Novel coumarin-6-sulfonamides as apoptotic anti-proliferative agents: synthesis, in vitro biological evaluation, and QSAR studies
por: Sabt, Ahmed, et al.
Publicado: (2018)

Design and synthesis of thiazolidine-2,4-diones hybrids with 1,2-dihydroquinolones and 2-oxindoles as potential VEGFR-2 inhibitors: in-vitro anticancer evaluation and in-silico studies
por: Taghour, Mohammed S., et al.
Publicado: (2022)

Discovery of 3,6-disubstituted pyridazines as a novel class of anticancer agents targeting cyclin-dependent kinase 2: synthesis, biological evaluation and in silico insights
por: Sabt, Ahmed, et al.
Publicado: (2020)

Novel 2-(5-Aryl-4,5-Dihydropyrazol-1-yl)thiazol-4-One as EGFR Inhibitors: Synthesis, Biological Assessment and Molecular Docking Insights
por: Al-Warhi, Tarfah, et al.
Publicado: (2022)

Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights
por: Badawi, Waleed A., et al.
Publicado: (2023)

The Anticancer Effects of the Pro-Apoptotic Benzofuran-Isatin Conjugate (5a) Are Associated With p53 Upregulation and Enhancement of Conventional Chemotherapeutic Drug Efficiency in Colorectal Cancer Cell Lines
por: Vaali-Mohammed, Mansoor-Ali, et al.
Publicado: (2022)

New [1,2,4]triazolo[4,3-c]quinazolines as intercalative Topo II inhibitors: Design, synthesis, biological evaluation, and in silico studies
por: Gaber, Ahmed A., et al.
Publicado: (2023)

Development of novel isatin–nicotinohydrazide hybrids with potent activity against susceptible/resistant Mycobacterium tuberculosis and bronchitis causing–bacteria
por: Elsayed, Zainab M., et al.
Publicado: (2021)

Design, Synthesis, In Silico and In Vitro Studies of New Immunomodulatory Anticancer Nicotinamide Derivatives Targeting VEGFR-2
por: Yousef, Reda G., et al.
Publicado: (2022)

Recent Synthetic Approaches towards Small Molecule Reactivators of p53
por: Silva, Jerson L., et al.
Publicado: (2020)

Recent Advances in Heterogeneous Photocatalytic Decolorization of Synthetic Dyes
por: Muhd Julkapli, Nurhidayatullaili, et al.
Publicado: (2014)

GC/MS Profiling, Anti-Collagenase, Anti-Elastase, Anti-Tyrosinase and Anti-Hyaluronidase Activities of a Stenocarpus sinuatus Leaves Extract
por: Younis, Mai M., et al.
Publicado: (2022)

Novel [(N-alkyl-3-indolylmethylene)hydrazono]oxindoles arrest cell cycle and induce cell apoptosis by inhibiting CDK2 and Bcl-2: synthesis, biological evaluation and in silico studies
por: Al-Warhi, Tarfah, et al.
Publicado: (2020)

Survivin Small Molecules Inhibitors: Recent Advances and Challenges
por: Albadari, Najah, et al.
Publicado: (2023)

Recent Advances in Small Molecule Inhibitors for the Treatment of Osteoarthritis
por: Lin, Jianjing, et al.
Publicado: (2023)

Recent advances in small molecules for improving mitochondrial disorders
por: Meng, Liying, et al.
Publicado: (2023)

Cancer stem cells CD133 inhibition and cytotoxicity of certain 3-phenylthiazolo[3,2-a]benzimidazoles: design, direct synthesis, crystal study and in vitro biological evaluation
por: Al-Ansary, Ghada H., et al.
Publicado: (2017)

Theophylline-based hybrids as acetylcholinesterase inhibitors endowed with anti-inflammatory activity: synthesis, bioevaluation, in silico and preliminary kinetic studies
por: Elgazar, Abdullah A., et al.
Publicado: (2023)

Recent Advances in Synthetic Bioelastomers
por: Shi, Rui, et al.
Publicado: (2009)

Recent advances in synthetic biosafety
por: Simon, Anna J., et al.
Publicado: (2016)

Editorial: Recent advances in the research and development of kinase-inhibitory anticancer molecules
por: Al-Karmalawy, Ahmed A., et al.
Publicado: (2023)

Synthesis, Molecular Docking, and Biofilm Formation Inhibitory Activity of Bis(Indolyl)Pyridines Analogues of the Marine Alkaloid Nortopsentin
por: Abo-Salem, Heba M., et al.
Publicado: (2021)

In Vivo and In Silico Investigation of the Anti-Obesity Effects of Lactiplantibacillus plantarum Combined with Chia Seeds, Green Tea, and Chitosan in Alleviating Hyperlipidemia and Inflammation
por: Elebeedy, Dalia, et al.
Publicado: (2022)

Small Molecule Inhibitors for Hepatocellular Carcinoma: Advances and Challenges
por: Kamal, Monica A., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_sf2j1gqfevna9i5e5122vrbbp1