Cargando…

The Vitamin D Decrease in Children with Obesity Is Associated with the Development of Insulin Resistance during Puberty: The PUBMEP Study

Obesity and cardiometabolic risk have been associated with vitamin D levels even in children. The objective of the present study was to evaluate the association between insulin resistance (IR), cardiometabolic risk factors, and vitamin D in children from prepubertal to pubertal stages. A total of 76...

Descripción completa

Detalles Bibliográficos
Autores principales: Pires, Liliane Viana, González-Gil, Esther M., Anguita-Ruiz, Augusto, Bueno, Gloria, Gil-Campos, Mercedes, Vázquez-Cobela, Rocío, Pérez-Ferreirós, Alexandra, Moreno, Luis A., Gil, Ángel, Leis, Rosaura, Aguilera, Concepción M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709093/
https://www.ncbi.nlm.nih.gov/pubmed/34960039
http://dx.doi.org/10.3390/nu13124488
_version_ 1784622849299841024
author Pires, Liliane Viana
González-Gil, Esther M.
Anguita-Ruiz, Augusto
Bueno, Gloria
Gil-Campos, Mercedes
Vázquez-Cobela, Rocío
Pérez-Ferreirós, Alexandra
Moreno, Luis A.
Gil, Ángel
Leis, Rosaura
Aguilera, Concepción M.
author_facet Pires, Liliane Viana
González-Gil, Esther M.
Anguita-Ruiz, Augusto
Bueno, Gloria
Gil-Campos, Mercedes
Vázquez-Cobela, Rocío
Pérez-Ferreirós, Alexandra
Moreno, Luis A.
Gil, Ángel
Leis, Rosaura
Aguilera, Concepción M.
author_sort Pires, Liliane Viana
collection PubMed
description Obesity and cardiometabolic risk have been associated with vitamin D levels even in children. The objective of the present study was to evaluate the association between insulin resistance (IR), cardiometabolic risk factors, and vitamin D in children from prepubertal to pubertal stages. A total of 76 children from the PUBMEP study, aged 4–12 years at baseline, were included. Children were evaluated in prepubertal and pubertal stages. Anthropometric measurements and selected cardiometabolic risk biomarkers, such as plasma glucose, blood lipids, insulin, adiponectin, leptin, and blood pressure, and serum 25-hydroxyvitamin D (25(OH)D) were determined. Children were categorized by obesity degree and IR status combined before and after puberty. Paired t-test and multivariate linear regression analyses were conducted. During puberty, the increase in triacylglycerols, insulin, and HOMA-IR and the decrease in QUICKI were significantly associated with the reduction in 25(OH)D (B = −0.274, p = 0.032; B = −0.219, p = 0.019; B = −0.250, p = 0.013; B = 1.574, p = 0.013, respectively) after adjustment by BMI-z, sex, and pubertal stage. Otherwise, prepubertal non-IR children with overweight/obesity that became IR during puberty showed a significant decrease in 25(OH)D and HDL-c, and an increase in waist circumference and triacylglycerol concentrations (p < 0.05 for all) over time. These results suggest that changes in IR seem to be associated with an effect on 25(OH)D levels during puberty, especially in children with overweight.
format Online
Article
Text
id pubmed-8709093
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87090932021-12-25 The Vitamin D Decrease in Children with Obesity Is Associated with the Development of Insulin Resistance during Puberty: The PUBMEP Study Pires, Liliane Viana González-Gil, Esther M. Anguita-Ruiz, Augusto Bueno, Gloria Gil-Campos, Mercedes Vázquez-Cobela, Rocío Pérez-Ferreirós, Alexandra Moreno, Luis A. Gil, Ángel Leis, Rosaura Aguilera, Concepción M. Nutrients Article Obesity and cardiometabolic risk have been associated with vitamin D levels even in children. The objective of the present study was to evaluate the association between insulin resistance (IR), cardiometabolic risk factors, and vitamin D in children from prepubertal to pubertal stages. A total of 76 children from the PUBMEP study, aged 4–12 years at baseline, were included. Children were evaluated in prepubertal and pubertal stages. Anthropometric measurements and selected cardiometabolic risk biomarkers, such as plasma glucose, blood lipids, insulin, adiponectin, leptin, and blood pressure, and serum 25-hydroxyvitamin D (25(OH)D) were determined. Children were categorized by obesity degree and IR status combined before and after puberty. Paired t-test and multivariate linear regression analyses were conducted. During puberty, the increase in triacylglycerols, insulin, and HOMA-IR and the decrease in QUICKI were significantly associated with the reduction in 25(OH)D (B = −0.274, p = 0.032; B = −0.219, p = 0.019; B = −0.250, p = 0.013; B = 1.574, p = 0.013, respectively) after adjustment by BMI-z, sex, and pubertal stage. Otherwise, prepubertal non-IR children with overweight/obesity that became IR during puberty showed a significant decrease in 25(OH)D and HDL-c, and an increase in waist circumference and triacylglycerol concentrations (p < 0.05 for all) over time. These results suggest that changes in IR seem to be associated with an effect on 25(OH)D levels during puberty, especially in children with overweight. MDPI 2021-12-15 /pmc/articles/PMC8709093/ /pubmed/34960039 http://dx.doi.org/10.3390/nu13124488 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pires, Liliane Viana
González-Gil, Esther M.
Anguita-Ruiz, Augusto
Bueno, Gloria
Gil-Campos, Mercedes
Vázquez-Cobela, Rocío
Pérez-Ferreirós, Alexandra
Moreno, Luis A.
Gil, Ángel
Leis, Rosaura
Aguilera, Concepción M.
The Vitamin D Decrease in Children with Obesity Is Associated with the Development of Insulin Resistance during Puberty: The PUBMEP Study
title The Vitamin D Decrease in Children with Obesity Is Associated with the Development of Insulin Resistance during Puberty: The PUBMEP Study
title_full The Vitamin D Decrease in Children with Obesity Is Associated with the Development of Insulin Resistance during Puberty: The PUBMEP Study
title_fullStr The Vitamin D Decrease in Children with Obesity Is Associated with the Development of Insulin Resistance during Puberty: The PUBMEP Study
title_full_unstemmed The Vitamin D Decrease in Children with Obesity Is Associated with the Development of Insulin Resistance during Puberty: The PUBMEP Study
title_short The Vitamin D Decrease in Children with Obesity Is Associated with the Development of Insulin Resistance during Puberty: The PUBMEP Study
title_sort vitamin d decrease in children with obesity is associated with the development of insulin resistance during puberty: the pubmep study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709093/
https://www.ncbi.nlm.nih.gov/pubmed/34960039
http://dx.doi.org/10.3390/nu13124488
work_keys_str_mv AT pireslilianeviana thevitaminddecreaseinchildrenwithobesityisassociatedwiththedevelopmentofinsulinresistanceduringpubertythepubmepstudy
AT gonzalezgilestherm thevitaminddecreaseinchildrenwithobesityisassociatedwiththedevelopmentofinsulinresistanceduringpubertythepubmepstudy
AT anguitaruizaugusto thevitaminddecreaseinchildrenwithobesityisassociatedwiththedevelopmentofinsulinresistanceduringpubertythepubmepstudy
AT buenogloria thevitaminddecreaseinchildrenwithobesityisassociatedwiththedevelopmentofinsulinresistanceduringpubertythepubmepstudy
AT gilcamposmercedes thevitaminddecreaseinchildrenwithobesityisassociatedwiththedevelopmentofinsulinresistanceduringpubertythepubmepstudy
AT vazquezcobelarocio thevitaminddecreaseinchildrenwithobesityisassociatedwiththedevelopmentofinsulinresistanceduringpubertythepubmepstudy
AT perezferreirosalexandra thevitaminddecreaseinchildrenwithobesityisassociatedwiththedevelopmentofinsulinresistanceduringpubertythepubmepstudy
AT morenoluisa thevitaminddecreaseinchildrenwithobesityisassociatedwiththedevelopmentofinsulinresistanceduringpubertythepubmepstudy
AT gilangel thevitaminddecreaseinchildrenwithobesityisassociatedwiththedevelopmentofinsulinresistanceduringpubertythepubmepstudy
AT leisrosaura thevitaminddecreaseinchildrenwithobesityisassociatedwiththedevelopmentofinsulinresistanceduringpubertythepubmepstudy
AT aguileraconcepcionm thevitaminddecreaseinchildrenwithobesityisassociatedwiththedevelopmentofinsulinresistanceduringpubertythepubmepstudy
AT pireslilianeviana vitaminddecreaseinchildrenwithobesityisassociatedwiththedevelopmentofinsulinresistanceduringpubertythepubmepstudy
AT gonzalezgilestherm vitaminddecreaseinchildrenwithobesityisassociatedwiththedevelopmentofinsulinresistanceduringpubertythepubmepstudy
AT anguitaruizaugusto vitaminddecreaseinchildrenwithobesityisassociatedwiththedevelopmentofinsulinresistanceduringpubertythepubmepstudy
AT buenogloria vitaminddecreaseinchildrenwithobesityisassociatedwiththedevelopmentofinsulinresistanceduringpubertythepubmepstudy
AT gilcamposmercedes vitaminddecreaseinchildrenwithobesityisassociatedwiththedevelopmentofinsulinresistanceduringpubertythepubmepstudy
AT vazquezcobelarocio vitaminddecreaseinchildrenwithobesityisassociatedwiththedevelopmentofinsulinresistanceduringpubertythepubmepstudy
AT perezferreirosalexandra vitaminddecreaseinchildrenwithobesityisassociatedwiththedevelopmentofinsulinresistanceduringpubertythepubmepstudy
AT morenoluisa vitaminddecreaseinchildrenwithobesityisassociatedwiththedevelopmentofinsulinresistanceduringpubertythepubmepstudy
AT gilangel vitaminddecreaseinchildrenwithobesityisassociatedwiththedevelopmentofinsulinresistanceduringpubertythepubmepstudy
AT leisrosaura vitaminddecreaseinchildrenwithobesityisassociatedwiththedevelopmentofinsulinresistanceduringpubertythepubmepstudy
AT aguileraconcepcionm vitaminddecreaseinchildrenwithobesityisassociatedwiththedevelopmentofinsulinresistanceduringpubertythepubmepstudy