Alterations in CNS Functions and DNA Methylation in Rats after 24 h Exposure to Peat Smoke

The use of a developed experimental model of a natural fire made it possible to assess the consequences of 24 h exposure to peat combustion products in albino rats. Peat smoke exposure leads to behavioral disturbances in rats, characterized by an increase in locomotor activity and an increased level...

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Autores principales: Vokina, Vera A., Sosedova, Larisa M., Novikov, Mikhail A., Rukavishnikov, Viktor S., Kapustina, Ekaterina A., Alekseenko, Anton N., Andreeva, Elizaveta S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709141/
https://www.ncbi.nlm.nih.gov/pubmed/34941776
http://dx.doi.org/10.3390/toxics9120342
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author Vokina, Vera A.
Sosedova, Larisa M.
Novikov, Mikhail A.
Rukavishnikov, Viktor S.
Kapustina, Ekaterina A.
Alekseenko, Anton N.
Andreeva, Elizaveta S.
author_facet Vokina, Vera A.
Sosedova, Larisa M.
Novikov, Mikhail A.
Rukavishnikov, Viktor S.
Kapustina, Ekaterina A.
Alekseenko, Anton N.
Andreeva, Elizaveta S.
author_sort Vokina, Vera A.
collection PubMed
description The use of a developed experimental model of a natural fire made it possible to assess the consequences of 24 h exposure to peat combustion products in albino rats. Peat smoke exposure leads to behavioral disturbances in rats, characterized by an increase in locomotor activity and an increased level of anxiety. Indicators of brain bioelectrical activity of the exposed animals supported the state of anxiety and psychoemotional stress. Epigenetic changes in the blood cells of exposed animals were revealed under 24 h exposure to peat smoke, characterized by a decrease in the level of global DNA methylation.
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spelling pubmed-87091412021-12-25 Alterations in CNS Functions and DNA Methylation in Rats after 24 h Exposure to Peat Smoke Vokina, Vera A. Sosedova, Larisa M. Novikov, Mikhail A. Rukavishnikov, Viktor S. Kapustina, Ekaterina A. Alekseenko, Anton N. Andreeva, Elizaveta S. Toxics Article The use of a developed experimental model of a natural fire made it possible to assess the consequences of 24 h exposure to peat combustion products in albino rats. Peat smoke exposure leads to behavioral disturbances in rats, characterized by an increase in locomotor activity and an increased level of anxiety. Indicators of brain bioelectrical activity of the exposed animals supported the state of anxiety and psychoemotional stress. Epigenetic changes in the blood cells of exposed animals were revealed under 24 h exposure to peat smoke, characterized by a decrease in the level of global DNA methylation. MDPI 2021-12-08 /pmc/articles/PMC8709141/ /pubmed/34941776 http://dx.doi.org/10.3390/toxics9120342 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vokina, Vera A.
Sosedova, Larisa M.
Novikov, Mikhail A.
Rukavishnikov, Viktor S.
Kapustina, Ekaterina A.
Alekseenko, Anton N.
Andreeva, Elizaveta S.
Alterations in CNS Functions and DNA Methylation in Rats after 24 h Exposure to Peat Smoke
title Alterations in CNS Functions and DNA Methylation in Rats after 24 h Exposure to Peat Smoke
title_full Alterations in CNS Functions and DNA Methylation in Rats after 24 h Exposure to Peat Smoke
title_fullStr Alterations in CNS Functions and DNA Methylation in Rats after 24 h Exposure to Peat Smoke
title_full_unstemmed Alterations in CNS Functions and DNA Methylation in Rats after 24 h Exposure to Peat Smoke
title_short Alterations in CNS Functions and DNA Methylation in Rats after 24 h Exposure to Peat Smoke
title_sort alterations in cns functions and dna methylation in rats after 24 h exposure to peat smoke
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709141/
https://www.ncbi.nlm.nih.gov/pubmed/34941776
http://dx.doi.org/10.3390/toxics9120342
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