From Crystal Structures of RgIA4 in Complex with Ac-AChBP to Molecular Determinants of Its High Potency of α9α10 nAChR

α9-containing nicotinic acetylcholine receptors (nAChRs) have been shown to play critical roles in neuropathic pain. The α-conotoxin (α-CTx) RgIA and its analog RgIA4 were identified as the most selective inhibitor of α9α10 nAChR. However, the mechanism of their selectivity toward α9α10 nAChR remain...

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Detalles Bibliográficos
Autores principales: Pan, Si, Fan, Yingxu, Zhu, Xiaopeng, Xue, Yi, Luo, Sulan, Wang, Xinquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709174/
https://www.ncbi.nlm.nih.gov/pubmed/34940708
http://dx.doi.org/10.3390/md19120709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709174/
https://www.ncbi.nlm.nih.gov/pubmed/34940708
http://dx.doi.org/10.3390/md19120709

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