Parametric and Nonparametric Population Pharmacokinetic Models to Assess Probability of Target Attainment of Imipenem Concentrations in Critically Ill Patients

Population pharmacokinetic modeling and simulation (M&S) are used to improve antibiotic dosing. Little is known about the differences in parametric and nonparametric M&S. Our objectives were to compare (1) the external validation of parametric and nonparametric models of imipenem in critical...

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Detalles Bibliográficos
Autores principales: de Velde, Femke, de Winter, Brenda C. M., Neely, Michael N., Strojil, Jan, Yamada, Walter M., Harbarth, Stephan, Huttner, Angela, van Gelder, Teun, Koch, Birgit C. P., Muller, Anouk E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709176/
https://www.ncbi.nlm.nih.gov/pubmed/34959451
http://dx.doi.org/10.3390/pharmaceutics13122170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709176/
https://www.ncbi.nlm.nih.gov/pubmed/34959451
http://dx.doi.org/10.3390/pharmaceutics13122170

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