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Parametric and Nonparametric Population Pharmacokinetic Models to Assess Probability of Target Attainment of Imipenem Concentrations in Critically Ill Patients
Population pharmacokinetic modeling and simulation (M&S) are used to improve antibiotic dosing. Little is known about the differences in parametric and nonparametric M&S. Our objectives were to compare (1) the external validation of parametric and nonparametric models of imipenem in critical...
Autores principales: | de Velde, Femke, de Winter, Brenda C. M., Neely, Michael N., Strojil, Jan, Yamada, Walter M., Harbarth, Stephan, Huttner, Angela, van Gelder, Teun, Koch, Birgit C. P., Muller, Anouk E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709176/ https://www.ncbi.nlm.nih.gov/pubmed/34959451 http://dx.doi.org/10.3390/pharmaceutics13122170 |
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