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Vitamin D and Skin Cancer: An Epidemiological, Patient-Centered Update and Review
Background: The current vitamin D deficiency epidemic is accompanied by an increase in endemic skin cancer. There are still multiple controversies. This review aims to give practical recommendations regarding vitamin D among people at risk or with a personal history of skin cancer. Methods: Narrativ...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709188/ https://www.ncbi.nlm.nih.gov/pubmed/34959844 http://dx.doi.org/10.3390/nu13124292 |
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author | Martin-Gorgojo, Alejandro Gilaberte, Yolanda Nagore, Eduardo |
author_facet | Martin-Gorgojo, Alejandro Gilaberte, Yolanda Nagore, Eduardo |
author_sort | Martin-Gorgojo, Alejandro |
collection | PubMed |
description | Background: The current vitamin D deficiency epidemic is accompanied by an increase in endemic skin cancer. There are still multiple controversies. This review aims to give practical recommendations regarding vitamin D among people at risk or with a personal history of skin cancer. Methods: Narrative review including human research articles published between 2011 and 2021, elaborated bearing in mind an epidemiological, patient-centered approach. Results: Ultraviolet (UV) exposure (neither artificial nor natural) is not the ideal source to synthesize vitamin D. There is conflicting epidemiological evidence regarding vitamin D, non-melanoma skin cancer (NMSC), and cutaneous melanoma (CMM), confounded by the effect of sun exposure and other factors. Conclusions: Current evidence is controversial, and there are no widely applicable strategies. We propose three practical recommendations. Firstly, sun protection recommendations should be kept among people at risk or with a personal history of skin cancer. Secondly, vitamin D should preferably be sourced through diet. In patients with melanoma or at risk of cutaneous cancer, serum vitamin D checks are warranted to detect and avoid its insufficiency. |
format | Online Article Text |
id | pubmed-8709188 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87091882021-12-25 Vitamin D and Skin Cancer: An Epidemiological, Patient-Centered Update and Review Martin-Gorgojo, Alejandro Gilaberte, Yolanda Nagore, Eduardo Nutrients Review Background: The current vitamin D deficiency epidemic is accompanied by an increase in endemic skin cancer. There are still multiple controversies. This review aims to give practical recommendations regarding vitamin D among people at risk or with a personal history of skin cancer. Methods: Narrative review including human research articles published between 2011 and 2021, elaborated bearing in mind an epidemiological, patient-centered approach. Results: Ultraviolet (UV) exposure (neither artificial nor natural) is not the ideal source to synthesize vitamin D. There is conflicting epidemiological evidence regarding vitamin D, non-melanoma skin cancer (NMSC), and cutaneous melanoma (CMM), confounded by the effect of sun exposure and other factors. Conclusions: Current evidence is controversial, and there are no widely applicable strategies. We propose three practical recommendations. Firstly, sun protection recommendations should be kept among people at risk or with a personal history of skin cancer. Secondly, vitamin D should preferably be sourced through diet. In patients with melanoma or at risk of cutaneous cancer, serum vitamin D checks are warranted to detect and avoid its insufficiency. MDPI 2021-11-28 /pmc/articles/PMC8709188/ /pubmed/34959844 http://dx.doi.org/10.3390/nu13124292 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Martin-Gorgojo, Alejandro Gilaberte, Yolanda Nagore, Eduardo Vitamin D and Skin Cancer: An Epidemiological, Patient-Centered Update and Review |
title | Vitamin D and Skin Cancer: An Epidemiological, Patient-Centered Update and Review |
title_full | Vitamin D and Skin Cancer: An Epidemiological, Patient-Centered Update and Review |
title_fullStr | Vitamin D and Skin Cancer: An Epidemiological, Patient-Centered Update and Review |
title_full_unstemmed | Vitamin D and Skin Cancer: An Epidemiological, Patient-Centered Update and Review |
title_short | Vitamin D and Skin Cancer: An Epidemiological, Patient-Centered Update and Review |
title_sort | vitamin d and skin cancer: an epidemiological, patient-centered update and review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709188/ https://www.ncbi.nlm.nih.gov/pubmed/34959844 http://dx.doi.org/10.3390/nu13124292 |
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