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Vitamin D and Skin Cancer: An Epidemiological, Patient-Centered Update and Review

Background: The current vitamin D deficiency epidemic is accompanied by an increase in endemic skin cancer. There are still multiple controversies. This review aims to give practical recommendations regarding vitamin D among people at risk or with a personal history of skin cancer. Methods: Narrativ...

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Autores principales: Martin-Gorgojo, Alejandro, Gilaberte, Yolanda, Nagore, Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709188/
https://www.ncbi.nlm.nih.gov/pubmed/34959844
http://dx.doi.org/10.3390/nu13124292
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author Martin-Gorgojo, Alejandro
Gilaberte, Yolanda
Nagore, Eduardo
author_facet Martin-Gorgojo, Alejandro
Gilaberte, Yolanda
Nagore, Eduardo
author_sort Martin-Gorgojo, Alejandro
collection PubMed
description Background: The current vitamin D deficiency epidemic is accompanied by an increase in endemic skin cancer. There are still multiple controversies. This review aims to give practical recommendations regarding vitamin D among people at risk or with a personal history of skin cancer. Methods: Narrative review including human research articles published between 2011 and 2021, elaborated bearing in mind an epidemiological, patient-centered approach. Results: Ultraviolet (UV) exposure (neither artificial nor natural) is not the ideal source to synthesize vitamin D. There is conflicting epidemiological evidence regarding vitamin D, non-melanoma skin cancer (NMSC), and cutaneous melanoma (CMM), confounded by the effect of sun exposure and other factors. Conclusions: Current evidence is controversial, and there are no widely applicable strategies. We propose three practical recommendations. Firstly, sun protection recommendations should be kept among people at risk or with a personal history of skin cancer. Secondly, vitamin D should preferably be sourced through diet. In patients with melanoma or at risk of cutaneous cancer, serum vitamin D checks are warranted to detect and avoid its insufficiency.
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spelling pubmed-87091882021-12-25 Vitamin D and Skin Cancer: An Epidemiological, Patient-Centered Update and Review Martin-Gorgojo, Alejandro Gilaberte, Yolanda Nagore, Eduardo Nutrients Review Background: The current vitamin D deficiency epidemic is accompanied by an increase in endemic skin cancer. There are still multiple controversies. This review aims to give practical recommendations regarding vitamin D among people at risk or with a personal history of skin cancer. Methods: Narrative review including human research articles published between 2011 and 2021, elaborated bearing in mind an epidemiological, patient-centered approach. Results: Ultraviolet (UV) exposure (neither artificial nor natural) is not the ideal source to synthesize vitamin D. There is conflicting epidemiological evidence regarding vitamin D, non-melanoma skin cancer (NMSC), and cutaneous melanoma (CMM), confounded by the effect of sun exposure and other factors. Conclusions: Current evidence is controversial, and there are no widely applicable strategies. We propose three practical recommendations. Firstly, sun protection recommendations should be kept among people at risk or with a personal history of skin cancer. Secondly, vitamin D should preferably be sourced through diet. In patients with melanoma or at risk of cutaneous cancer, serum vitamin D checks are warranted to detect and avoid its insufficiency. MDPI 2021-11-28 /pmc/articles/PMC8709188/ /pubmed/34959844 http://dx.doi.org/10.3390/nu13124292 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Martin-Gorgojo, Alejandro
Gilaberte, Yolanda
Nagore, Eduardo
Vitamin D and Skin Cancer: An Epidemiological, Patient-Centered Update and Review
title Vitamin D and Skin Cancer: An Epidemiological, Patient-Centered Update and Review
title_full Vitamin D and Skin Cancer: An Epidemiological, Patient-Centered Update and Review
title_fullStr Vitamin D and Skin Cancer: An Epidemiological, Patient-Centered Update and Review
title_full_unstemmed Vitamin D and Skin Cancer: An Epidemiological, Patient-Centered Update and Review
title_short Vitamin D and Skin Cancer: An Epidemiological, Patient-Centered Update and Review
title_sort vitamin d and skin cancer: an epidemiological, patient-centered update and review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709188/
https://www.ncbi.nlm.nih.gov/pubmed/34959844
http://dx.doi.org/10.3390/nu13124292
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