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Incidence and Outcome of Coinfections with SARS-CoV-2 and Rhinovirus

Background: We aimed to compare the clinical severity in patients who were coinfected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and rhinovirus or monoinfected with a single one of these viruses. Methods: The study period ranged from 1 March 2020 to 28 February 2021 (one year)...

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Autores principales: Le Glass, Elisabeth, Hoang, Van Thuan, Boschi, Céline, Ninove, Laetitia, Zandotti, Christine, Boutin, Aurélie, Bremond, Valérie, Dubourg, Grégory, Ranque, Stéphane, Lagier, Jean-Christophe, Million, Matthieu, Fournier, Pierre-Edouard, Drancourt, Michel, Gautret, Philippe, Colson, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709236/
https://www.ncbi.nlm.nih.gov/pubmed/34960797
http://dx.doi.org/10.3390/v13122528
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author Le Glass, Elisabeth
Hoang, Van Thuan
Boschi, Céline
Ninove, Laetitia
Zandotti, Christine
Boutin, Aurélie
Bremond, Valérie
Dubourg, Grégory
Ranque, Stéphane
Lagier, Jean-Christophe
Million, Matthieu
Fournier, Pierre-Edouard
Drancourt, Michel
Gautret, Philippe
Colson, Philippe
author_facet Le Glass, Elisabeth
Hoang, Van Thuan
Boschi, Céline
Ninove, Laetitia
Zandotti, Christine
Boutin, Aurélie
Bremond, Valérie
Dubourg, Grégory
Ranque, Stéphane
Lagier, Jean-Christophe
Million, Matthieu
Fournier, Pierre-Edouard
Drancourt, Michel
Gautret, Philippe
Colson, Philippe
author_sort Le Glass, Elisabeth
collection PubMed
description Background: We aimed to compare the clinical severity in patients who were coinfected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and rhinovirus or monoinfected with a single one of these viruses. Methods: The study period ranged from 1 March 2020 to 28 February 2021 (one year). SARS-CoV-2 and other respiratory viruses were identified by real-time reverse-transcription-PCR as part of the routine work at Marseille University hospitals. Bacterial and fungal infections were detected by standard methods. Clinical data were retrospectively collected from medical files. This study was approved by the ethical committee of our institute. Results: A total of 6034/15,157 (40%) tested patients were positive for at least one respiratory virus. Ninety-three (4.3%) SARS-CoV-2-infected patients were coinfected with another respiratory virus, with rhinovirus being the most frequent (62/93, 67%). Patients coinfected with SARS-CoV-2 and rhinovirus were significantly more likely to report a cough than those with SARS-CoV-2 monoinfection (62% vs. 31%; p = 0.0008). In addition, they were also significantly more likely to report dyspnea than patients with rhinovirus monoinfection (45% vs. 36%; p = 0.02). They were also more likely to be transferred to an intensive care unit and to die than patients with rhinovirus monoinfection (16% vs. 5% and 7% vs. 2%, respectively) but these differences were not statistically significant. Conclusions: A close surveillance and investigation of the co-incidence and interactions of SARS-CoV-2 and other respiratory viruses is needed. The possible higher risk of increased clinical severity in SARS-CoV-2-positive patients coinfected with rhinovirus warrants further large scale studies.
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spelling pubmed-87092362021-12-25 Incidence and Outcome of Coinfections with SARS-CoV-2 and Rhinovirus Le Glass, Elisabeth Hoang, Van Thuan Boschi, Céline Ninove, Laetitia Zandotti, Christine Boutin, Aurélie Bremond, Valérie Dubourg, Grégory Ranque, Stéphane Lagier, Jean-Christophe Million, Matthieu Fournier, Pierre-Edouard Drancourt, Michel Gautret, Philippe Colson, Philippe Viruses Brief Report Background: We aimed to compare the clinical severity in patients who were coinfected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and rhinovirus or monoinfected with a single one of these viruses. Methods: The study period ranged from 1 March 2020 to 28 February 2021 (one year). SARS-CoV-2 and other respiratory viruses were identified by real-time reverse-transcription-PCR as part of the routine work at Marseille University hospitals. Bacterial and fungal infections were detected by standard methods. Clinical data were retrospectively collected from medical files. This study was approved by the ethical committee of our institute. Results: A total of 6034/15,157 (40%) tested patients were positive for at least one respiratory virus. Ninety-three (4.3%) SARS-CoV-2-infected patients were coinfected with another respiratory virus, with rhinovirus being the most frequent (62/93, 67%). Patients coinfected with SARS-CoV-2 and rhinovirus were significantly more likely to report a cough than those with SARS-CoV-2 monoinfection (62% vs. 31%; p = 0.0008). In addition, they were also significantly more likely to report dyspnea than patients with rhinovirus monoinfection (45% vs. 36%; p = 0.02). They were also more likely to be transferred to an intensive care unit and to die than patients with rhinovirus monoinfection (16% vs. 5% and 7% vs. 2%, respectively) but these differences were not statistically significant. Conclusions: A close surveillance and investigation of the co-incidence and interactions of SARS-CoV-2 and other respiratory viruses is needed. The possible higher risk of increased clinical severity in SARS-CoV-2-positive patients coinfected with rhinovirus warrants further large scale studies. MDPI 2021-12-16 /pmc/articles/PMC8709236/ /pubmed/34960797 http://dx.doi.org/10.3390/v13122528 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Le Glass, Elisabeth
Hoang, Van Thuan
Boschi, Céline
Ninove, Laetitia
Zandotti, Christine
Boutin, Aurélie
Bremond, Valérie
Dubourg, Grégory
Ranque, Stéphane
Lagier, Jean-Christophe
Million, Matthieu
Fournier, Pierre-Edouard
Drancourt, Michel
Gautret, Philippe
Colson, Philippe
Incidence and Outcome of Coinfections with SARS-CoV-2 and Rhinovirus
title Incidence and Outcome of Coinfections with SARS-CoV-2 and Rhinovirus
title_full Incidence and Outcome of Coinfections with SARS-CoV-2 and Rhinovirus
title_fullStr Incidence and Outcome of Coinfections with SARS-CoV-2 and Rhinovirus
title_full_unstemmed Incidence and Outcome of Coinfections with SARS-CoV-2 and Rhinovirus
title_short Incidence and Outcome of Coinfections with SARS-CoV-2 and Rhinovirus
title_sort incidence and outcome of coinfections with sars-cov-2 and rhinovirus
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709236/
https://www.ncbi.nlm.nih.gov/pubmed/34960797
http://dx.doi.org/10.3390/v13122528
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