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In Search of Small Molecules That Selectively Inhibit MBOAT4

Ghrelin is a 28-residue peptide hormone produced by stomach P/D1 cells located in oxyntic glands of the fundus mucosa. Post-translational octanoylation of its Ser-3 residue, catalyzed by MBOAT4 (aka ghrelin O-acyl transferase (GOAT)), is essential for the binding of the hormone to its receptor in ta...

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Detalles Bibliográficos
Autores principales:	Murzinski, Emily S., Saha, Ishika, Ding, Hui, Strugatsky, David, Hollibaugh, Ryan A., Liu, Haixia, Tontonoz, Peter, Harran, Patrick G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709388/ https://www.ncbi.nlm.nih.gov/pubmed/34946685 http://dx.doi.org/10.3390/molecules26247599

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