Molecular Pathogenesis and the Possible Role of Mitochondrial Heteroplasmy in Thoracic Aortic Aneurysm

Thoracic aortic aneurysm (TAA) is a life-threatening condition associated with high mortality, in which the aortic wall is deformed due to congenital or age-associated pathological changes. The mechanisms of TAA development remain to be studied in detail, and are the subject of active research. In t...

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Autores principales: Suslov, A. V., Afanasyev, M. A., Degtyarev, P. A., Chumachenko, P. V., Ekta, M. Bagheri, Sukhorukov, V. N., Khotina, V. A., Yet, S.-F., Sobenin, I. A., Postnov, A. Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709403/
https://www.ncbi.nlm.nih.gov/pubmed/34947926
http://dx.doi.org/10.3390/life11121395
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author Suslov, A. V.
Afanasyev, M. A.
Degtyarev, P. A.
Chumachenko, P. V.
Ekta, M. Bagheri
Sukhorukov, V. N.
Khotina, V. A.
Yet, S.-F.
Sobenin, I. A.
Postnov, A. Yu
author_facet Suslov, A. V.
Afanasyev, M. A.
Degtyarev, P. A.
Chumachenko, P. V.
Ekta, M. Bagheri
Sukhorukov, V. N.
Khotina, V. A.
Yet, S.-F.
Sobenin, I. A.
Postnov, A. Yu
author_sort Suslov, A. V.
collection PubMed
description Thoracic aortic aneurysm (TAA) is a life-threatening condition associated with high mortality, in which the aortic wall is deformed due to congenital or age-associated pathological changes. The mechanisms of TAA development remain to be studied in detail, and are the subject of active research. In this review, we describe the morphological changes of the aortic wall in TAA. We outline the genetic disorders associated with aortic enlargement and discuss the potential role of mitochondrial pathology, in particular mitochondrial DNA heteroplasmy, in the disease pathogenesis.
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spelling pubmed-87094032021-12-25 Molecular Pathogenesis and the Possible Role of Mitochondrial Heteroplasmy in Thoracic Aortic Aneurysm Suslov, A. V. Afanasyev, M. A. Degtyarev, P. A. Chumachenko, P. V. Ekta, M. Bagheri Sukhorukov, V. N. Khotina, V. A. Yet, S.-F. Sobenin, I. A. Postnov, A. Yu Life (Basel) Review Thoracic aortic aneurysm (TAA) is a life-threatening condition associated with high mortality, in which the aortic wall is deformed due to congenital or age-associated pathological changes. The mechanisms of TAA development remain to be studied in detail, and are the subject of active research. In this review, we describe the morphological changes of the aortic wall in TAA. We outline the genetic disorders associated with aortic enlargement and discuss the potential role of mitochondrial pathology, in particular mitochondrial DNA heteroplasmy, in the disease pathogenesis. MDPI 2021-12-13 /pmc/articles/PMC8709403/ /pubmed/34947926 http://dx.doi.org/10.3390/life11121395 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Suslov, A. V.
Afanasyev, M. A.
Degtyarev, P. A.
Chumachenko, P. V.
Ekta, M. Bagheri
Sukhorukov, V. N.
Khotina, V. A.
Yet, S.-F.
Sobenin, I. A.
Postnov, A. Yu
Molecular Pathogenesis and the Possible Role of Mitochondrial Heteroplasmy in Thoracic Aortic Aneurysm
title Molecular Pathogenesis and the Possible Role of Mitochondrial Heteroplasmy in Thoracic Aortic Aneurysm
title_full Molecular Pathogenesis and the Possible Role of Mitochondrial Heteroplasmy in Thoracic Aortic Aneurysm
title_fullStr Molecular Pathogenesis and the Possible Role of Mitochondrial Heteroplasmy in Thoracic Aortic Aneurysm
title_full_unstemmed Molecular Pathogenesis and the Possible Role of Mitochondrial Heteroplasmy in Thoracic Aortic Aneurysm
title_short Molecular Pathogenesis and the Possible Role of Mitochondrial Heteroplasmy in Thoracic Aortic Aneurysm
title_sort molecular pathogenesis and the possible role of mitochondrial heteroplasmy in thoracic aortic aneurysm
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709403/
https://www.ncbi.nlm.nih.gov/pubmed/34947926
http://dx.doi.org/10.3390/life11121395
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