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Association between Levels of Urine Di-(2-ethylhexyl)phthalate Metabolites and Heart Rate Variability in Young Adults

Phthalate exposure is associated with cardiovascular risk. Among the various phthalates, di-(2-ethylhexyl) phthalate (DEHP) is a deleterious plasticizer in our daily lives. This study investigated the association between DEHP exposure and the alteration of heart rate variability (HRV). During 2017–2...

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Autores principales: Chen, Ching-Way, Tang, Shu-Yu, Hwang, Jin-Shiang, Chan, Chang-Chuan, Hsu, Cheng-Chih, Lin, Chien-Yu, Su, Ta-Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709404/
https://www.ncbi.nlm.nih.gov/pubmed/34941785
http://dx.doi.org/10.3390/toxics9120351
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author Chen, Ching-Way
Tang, Shu-Yu
Hwang, Jin-Shiang
Chan, Chang-Chuan
Hsu, Cheng-Chih
Lin, Chien-Yu
Su, Ta-Chen
author_facet Chen, Ching-Way
Tang, Shu-Yu
Hwang, Jin-Shiang
Chan, Chang-Chuan
Hsu, Cheng-Chih
Lin, Chien-Yu
Su, Ta-Chen
author_sort Chen, Ching-Way
collection PubMed
description Phthalate exposure is associated with cardiovascular risk. Among the various phthalates, di-(2-ethylhexyl) phthalate (DEHP) is a deleterious plasticizer in our daily lives. This study investigated the association between DEHP exposure and the alteration of heart rate variability (HRV). During 2017–2019, we recruited 974 young adults to investigate the effects of living environments and dietary habits on cardiometabolic disorders in Taiwan. We quantitatively analyzed urinary metabolites of DHEP. A continuous electrocardiogram was recorded to obtain a 5-min ECG. Time-domain and frequency-domain HRV analyses were performed. Multiple linear regression showed that urinary oxidized DEHP metabolites MEHHP and MEOHP were associated with decreased HRV after controlling for associated cardiovascular risk factors. A higher MEHHP level was associated with a lower triangular interpolation of NN interval histogram (TINN), very low frequency (VLF), and low frequency/high frequency (LF/HF) ratio. A higher MEOHP level was associated with a decreased LF/HF ratio. In addition, trend analysis showed that higher MEHHP and MEOHP quantiles were significantly associated with a decreased LF/HF ratio. DEHP is a potentially harmful and invisible chemical. The urinary DEHP metabolites MEHHP and MEOHP are associated with decreased HRV, indicating an adverse effect on autonomic balance in young adults in Taiwan.
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spelling pubmed-87094042021-12-25 Association between Levels of Urine Di-(2-ethylhexyl)phthalate Metabolites and Heart Rate Variability in Young Adults Chen, Ching-Way Tang, Shu-Yu Hwang, Jin-Shiang Chan, Chang-Chuan Hsu, Cheng-Chih Lin, Chien-Yu Su, Ta-Chen Toxics Article Phthalate exposure is associated with cardiovascular risk. Among the various phthalates, di-(2-ethylhexyl) phthalate (DEHP) is a deleterious plasticizer in our daily lives. This study investigated the association between DEHP exposure and the alteration of heart rate variability (HRV). During 2017–2019, we recruited 974 young adults to investigate the effects of living environments and dietary habits on cardiometabolic disorders in Taiwan. We quantitatively analyzed urinary metabolites of DHEP. A continuous electrocardiogram was recorded to obtain a 5-min ECG. Time-domain and frequency-domain HRV analyses were performed. Multiple linear regression showed that urinary oxidized DEHP metabolites MEHHP and MEOHP were associated with decreased HRV after controlling for associated cardiovascular risk factors. A higher MEHHP level was associated with a lower triangular interpolation of NN interval histogram (TINN), very low frequency (VLF), and low frequency/high frequency (LF/HF) ratio. A higher MEOHP level was associated with a decreased LF/HF ratio. In addition, trend analysis showed that higher MEHHP and MEOHP quantiles were significantly associated with a decreased LF/HF ratio. DEHP is a potentially harmful and invisible chemical. The urinary DEHP metabolites MEHHP and MEOHP are associated with decreased HRV, indicating an adverse effect on autonomic balance in young adults in Taiwan. MDPI 2021-12-12 /pmc/articles/PMC8709404/ /pubmed/34941785 http://dx.doi.org/10.3390/toxics9120351 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Ching-Way
Tang, Shu-Yu
Hwang, Jin-Shiang
Chan, Chang-Chuan
Hsu, Cheng-Chih
Lin, Chien-Yu
Su, Ta-Chen
Association between Levels of Urine Di-(2-ethylhexyl)phthalate Metabolites and Heart Rate Variability in Young Adults
title Association between Levels of Urine Di-(2-ethylhexyl)phthalate Metabolites and Heart Rate Variability in Young Adults
title_full Association between Levels of Urine Di-(2-ethylhexyl)phthalate Metabolites and Heart Rate Variability in Young Adults
title_fullStr Association between Levels of Urine Di-(2-ethylhexyl)phthalate Metabolites and Heart Rate Variability in Young Adults
title_full_unstemmed Association between Levels of Urine Di-(2-ethylhexyl)phthalate Metabolites and Heart Rate Variability in Young Adults
title_short Association between Levels of Urine Di-(2-ethylhexyl)phthalate Metabolites and Heart Rate Variability in Young Adults
title_sort association between levels of urine di-(2-ethylhexyl)phthalate metabolites and heart rate variability in young adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709404/
https://www.ncbi.nlm.nih.gov/pubmed/34941785
http://dx.doi.org/10.3390/toxics9120351
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