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Taste sensing and sugar detection mechanisms in Drosophila larval primary taste center
Despite the small number of gustatory sense neurons, Drosophila larvae are able to sense a wide range of chemicals. Although evidence for taste multimodality has been provided in single neurons, an overview of gustatory responses at the periphery is missing and hereby we explore whole-organ calcium...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709573/ https://www.ncbi.nlm.nih.gov/pubmed/34859782 http://dx.doi.org/10.7554/eLife.67844 |
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author | Maier, G Larisa Komarov, Nikita Meyenhofer, Felix Kwon, Jae Young Sprecher, Simon G |
author_facet | Maier, G Larisa Komarov, Nikita Meyenhofer, Felix Kwon, Jae Young Sprecher, Simon G |
author_sort | Maier, G Larisa |
collection | PubMed |
description | Despite the small number of gustatory sense neurons, Drosophila larvae are able to sense a wide range of chemicals. Although evidence for taste multimodality has been provided in single neurons, an overview of gustatory responses at the periphery is missing and hereby we explore whole-organ calcium imaging of the external taste center. We find that neurons can be activated by different combinations of taste modalities, including opposite hedonic valence and identify distinct temporal dynamics of response. Although sweet sensing has not been fully characterized so far in the external larval gustatory organ, we recorded responses elicited by sugar. Previous findings established that larval sugar sensing relies on the Gr43a pharyngeal receptor, but the question remains if external neurons contribute to this taste. Here, we postulate that external and internal gustation use distinct and complementary mechanisms in sugar sensing and we identify external sucrose sensing neurons. |
format | Online Article Text |
id | pubmed-8709573 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-87095732022-01-04 Taste sensing and sugar detection mechanisms in Drosophila larval primary taste center Maier, G Larisa Komarov, Nikita Meyenhofer, Felix Kwon, Jae Young Sprecher, Simon G eLife Neuroscience Despite the small number of gustatory sense neurons, Drosophila larvae are able to sense a wide range of chemicals. Although evidence for taste multimodality has been provided in single neurons, an overview of gustatory responses at the periphery is missing and hereby we explore whole-organ calcium imaging of the external taste center. We find that neurons can be activated by different combinations of taste modalities, including opposite hedonic valence and identify distinct temporal dynamics of response. Although sweet sensing has not been fully characterized so far in the external larval gustatory organ, we recorded responses elicited by sugar. Previous findings established that larval sugar sensing relies on the Gr43a pharyngeal receptor, but the question remains if external neurons contribute to this taste. Here, we postulate that external and internal gustation use distinct and complementary mechanisms in sugar sensing and we identify external sucrose sensing neurons. eLife Sciences Publications, Ltd 2021-12-03 /pmc/articles/PMC8709573/ /pubmed/34859782 http://dx.doi.org/10.7554/eLife.67844 Text en © 2021, Maier et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Maier, G Larisa Komarov, Nikita Meyenhofer, Felix Kwon, Jae Young Sprecher, Simon G Taste sensing and sugar detection mechanisms in Drosophila larval primary taste center |
title | Taste sensing and sugar detection mechanisms in Drosophila larval primary taste center |
title_full | Taste sensing and sugar detection mechanisms in Drosophila larval primary taste center |
title_fullStr | Taste sensing and sugar detection mechanisms in Drosophila larval primary taste center |
title_full_unstemmed | Taste sensing and sugar detection mechanisms in Drosophila larval primary taste center |
title_short | Taste sensing and sugar detection mechanisms in Drosophila larval primary taste center |
title_sort | taste sensing and sugar detection mechanisms in drosophila larval primary taste center |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709573/ https://www.ncbi.nlm.nih.gov/pubmed/34859782 http://dx.doi.org/10.7554/eLife.67844 |
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