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Reduced White Matter Integrity in Patients With End-Stage and Non-end-Stage Chronic Kidney Disease: A Tract-Based Spatial Statistics Study

Background and Purpose: Reduced white matter (WM) integrity has been implicated in chronic kidney disease (CKD), especially in end-stage renal disease (ESRD). However, whether the differences in WM abnormalities exist in ESRD and non-end-stage CKD (NES-CKD) remains unclear. Hence, this study aimed t...

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Autores principales: Jiang, Yuhan, Gao, Qiuyi, Liu, Yangyingqiu, Gao, Bingbing, Che, Yiwei, Lin, Liangjie, Jiang, Jian, Chang, Peipei, Song, Qingwei, Wang, Weiwei, Wang, Nan, Miao, Yanwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709581/
https://www.ncbi.nlm.nih.gov/pubmed/34955791
http://dx.doi.org/10.3389/fnhum.2021.774236
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author Jiang, Yuhan
Gao, Qiuyi
Liu, Yangyingqiu
Gao, Bingbing
Che, Yiwei
Lin, Liangjie
Jiang, Jian
Chang, Peipei
Song, Qingwei
Wang, Weiwei
Wang, Nan
Miao, Yanwei
author_facet Jiang, Yuhan
Gao, Qiuyi
Liu, Yangyingqiu
Gao, Bingbing
Che, Yiwei
Lin, Liangjie
Jiang, Jian
Chang, Peipei
Song, Qingwei
Wang, Weiwei
Wang, Nan
Miao, Yanwei
author_sort Jiang, Yuhan
collection PubMed
description Background and Purpose: Reduced white matter (WM) integrity has been implicated in chronic kidney disease (CKD), especially in end-stage renal disease (ESRD). However, whether the differences in WM abnormalities exist in ESRD and non-end-stage CKD (NES-CKD) remains unclear. Hence, this study aimed to investigate the WM microstructural changes between the two stages using diffusion tensor imaging (DTI) and explore the related influencing factors. Methods: Diffusion tensor imaging’ images were prospectively acquired from 18 patients with ESRD, 22 patients with NES-CKD, and 19 healthy controls (HCs). Tract-based spatial statistics (TBSS) was performed to assess the voxel-wise differences in WM abnormalities among the three groups. The relationships between DTI parameters and biochemical data were also analyzed. Results: Compared with NES-CKDs, FA value was significantly decreased, and AD value increased in ESRDs mainly in brain regions of bilateral anterior thalamic radiation (ATR), the genu and body of corpus callosum (CC), bilateral anterior corona radiata, superior corona radiata, and superior longitudinal fasciculus. Besides, extensive and symmetrical deep WM damages were observed in patients with ESRD, accompanied by increased MD and RD values. Multiple regression analysis revealed that uric acid and serum phosphorus level can be used as independent predictors of WM microstructural abnormalities in clusters with statistical differences in DTI parameters between ESRD and NES-CKD groups. Conclusion: In the progression of CKD, patients with ESRD have more severe WM microstructural abnormalities than NES-CKDs, and this progressive deterioration may be related to uric acid and phosphate levels.
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spelling pubmed-87095812021-12-25 Reduced White Matter Integrity in Patients With End-Stage and Non-end-Stage Chronic Kidney Disease: A Tract-Based Spatial Statistics Study Jiang, Yuhan Gao, Qiuyi Liu, Yangyingqiu Gao, Bingbing Che, Yiwei Lin, Liangjie Jiang, Jian Chang, Peipei Song, Qingwei Wang, Weiwei Wang, Nan Miao, Yanwei Front Hum Neurosci Neuroscience Background and Purpose: Reduced white matter (WM) integrity has been implicated in chronic kidney disease (CKD), especially in end-stage renal disease (ESRD). However, whether the differences in WM abnormalities exist in ESRD and non-end-stage CKD (NES-CKD) remains unclear. Hence, this study aimed to investigate the WM microstructural changes between the two stages using diffusion tensor imaging (DTI) and explore the related influencing factors. Methods: Diffusion tensor imaging’ images were prospectively acquired from 18 patients with ESRD, 22 patients with NES-CKD, and 19 healthy controls (HCs). Tract-based spatial statistics (TBSS) was performed to assess the voxel-wise differences in WM abnormalities among the three groups. The relationships between DTI parameters and biochemical data were also analyzed. Results: Compared with NES-CKDs, FA value was significantly decreased, and AD value increased in ESRDs mainly in brain regions of bilateral anterior thalamic radiation (ATR), the genu and body of corpus callosum (CC), bilateral anterior corona radiata, superior corona radiata, and superior longitudinal fasciculus. Besides, extensive and symmetrical deep WM damages were observed in patients with ESRD, accompanied by increased MD and RD values. Multiple regression analysis revealed that uric acid and serum phosphorus level can be used as independent predictors of WM microstructural abnormalities in clusters with statistical differences in DTI parameters between ESRD and NES-CKD groups. Conclusion: In the progression of CKD, patients with ESRD have more severe WM microstructural abnormalities than NES-CKDs, and this progressive deterioration may be related to uric acid and phosphate levels. Frontiers Media S.A. 2021-12-10 /pmc/articles/PMC8709581/ /pubmed/34955791 http://dx.doi.org/10.3389/fnhum.2021.774236 Text en Copyright © 2021 Jiang, Gao, Liu, Gao, Che, Lin, Jiang, Chang, Song, Wang, Wang and Miao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Jiang, Yuhan
Gao, Qiuyi
Liu, Yangyingqiu
Gao, Bingbing
Che, Yiwei
Lin, Liangjie
Jiang, Jian
Chang, Peipei
Song, Qingwei
Wang, Weiwei
Wang, Nan
Miao, Yanwei
Reduced White Matter Integrity in Patients With End-Stage and Non-end-Stage Chronic Kidney Disease: A Tract-Based Spatial Statistics Study
title Reduced White Matter Integrity in Patients With End-Stage and Non-end-Stage Chronic Kidney Disease: A Tract-Based Spatial Statistics Study
title_full Reduced White Matter Integrity in Patients With End-Stage and Non-end-Stage Chronic Kidney Disease: A Tract-Based Spatial Statistics Study
title_fullStr Reduced White Matter Integrity in Patients With End-Stage and Non-end-Stage Chronic Kidney Disease: A Tract-Based Spatial Statistics Study
title_full_unstemmed Reduced White Matter Integrity in Patients With End-Stage and Non-end-Stage Chronic Kidney Disease: A Tract-Based Spatial Statistics Study
title_short Reduced White Matter Integrity in Patients With End-Stage and Non-end-Stage Chronic Kidney Disease: A Tract-Based Spatial Statistics Study
title_sort reduced white matter integrity in patients with end-stage and non-end-stage chronic kidney disease: a tract-based spatial statistics study
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709581/
https://www.ncbi.nlm.nih.gov/pubmed/34955791
http://dx.doi.org/10.3389/fnhum.2021.774236
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