Cargando…

Clinical Efficacy of Fuzheng Guben Anticancer Decoction Combined with Taxol in Treating Ovarian Carcinoma and Its Effect on Complication Incidence

OBJECTIVE: To investigate the clinical value of Fuzheng Guben anticancer decoction combined with taxol in treating ovarian carcinoma (OC). METHODS: The medical records of 80 OC patients treated in the First People's Hospital of Fuyang Hangzhou (January 2018–January 2021) were retrospectively an...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Pinger, Lou, Yinmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709778/
https://www.ncbi.nlm.nih.gov/pubmed/34374730
http://dx.doi.org/10.1155/2021/2782875
_version_ 1784623017821732864
author Li, Pinger
Lou, Yinmei
author_facet Li, Pinger
Lou, Yinmei
author_sort Li, Pinger
collection PubMed
description OBJECTIVE: To investigate the clinical value of Fuzheng Guben anticancer decoction combined with taxol in treating ovarian carcinoma (OC). METHODS: The medical records of 80 OC patients treated in the First People's Hospital of Fuyang Hangzhou (January 2018–January 2021) were retrospectively analyzed, and the patients were split into the control group and the experimental group according to the treatment regimen, with 40 cases each. Those in the control group accepted the taxol chemotherapy, and on this basis, those in the experimental group took the Fuzheng Guben anticancer decoction, so as to compare its clinical efficacy and complication incidence. RESULTS: No statistical between-group differences in patients' general information were observed (P > 0.05); compared with the control group, the disease objective remission rate of the experimental group was greatly higher (P < 0.05); before and after treatment, the changes in CD8(+) were not significant, indicating no statistically significant between-group differences (P > 0.05), and after treatment, CD3(+), CD4(+), and CD4(+)/CD8(+) were obviously higher than before and were obviously higher in the experimental group than in the control group (P < 0.05); after treatment, the CA125, CA199, and CEA levels were obviously lower than before and were significantly lower in the experimental group than in the control group (P < 0.05); the mean survival of the experimental group was significantly higher than that of the control group (19.80 ± 5.84 vs. 14.075 ± 5.12 months, P < 0.05); and between the two groups, the incidence rate of adverse reactions of the experimental group was remarkably lower (P < 0.05). CONCLUSION: On the basis of taxol chemotherapy, jointly applying Fuzheng Guben anticancer decoction can significantly improve the clinical efficacy of OC, help to improve patients' immune function, lower the complication incidence rate, and prolong the mean survival.
format Online
Article
Text
id pubmed-8709778
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-87097782021-12-25 Clinical Efficacy of Fuzheng Guben Anticancer Decoction Combined with Taxol in Treating Ovarian Carcinoma and Its Effect on Complication Incidence Li, Pinger Lou, Yinmei Evid Based Complement Alternat Med Research Article OBJECTIVE: To investigate the clinical value of Fuzheng Guben anticancer decoction combined with taxol in treating ovarian carcinoma (OC). METHODS: The medical records of 80 OC patients treated in the First People's Hospital of Fuyang Hangzhou (January 2018–January 2021) were retrospectively analyzed, and the patients were split into the control group and the experimental group according to the treatment regimen, with 40 cases each. Those in the control group accepted the taxol chemotherapy, and on this basis, those in the experimental group took the Fuzheng Guben anticancer decoction, so as to compare its clinical efficacy and complication incidence. RESULTS: No statistical between-group differences in patients' general information were observed (P > 0.05); compared with the control group, the disease objective remission rate of the experimental group was greatly higher (P < 0.05); before and after treatment, the changes in CD8(+) were not significant, indicating no statistically significant between-group differences (P > 0.05), and after treatment, CD3(+), CD4(+), and CD4(+)/CD8(+) were obviously higher than before and were obviously higher in the experimental group than in the control group (P < 0.05); after treatment, the CA125, CA199, and CEA levels were obviously lower than before and were significantly lower in the experimental group than in the control group (P < 0.05); the mean survival of the experimental group was significantly higher than that of the control group (19.80 ± 5.84 vs. 14.075 ± 5.12 months, P < 0.05); and between the two groups, the incidence rate of adverse reactions of the experimental group was remarkably lower (P < 0.05). CONCLUSION: On the basis of taxol chemotherapy, jointly applying Fuzheng Guben anticancer decoction can significantly improve the clinical efficacy of OC, help to improve patients' immune function, lower the complication incidence rate, and prolong the mean survival. Hindawi 2021-12-17 /pmc/articles/PMC8709778/ /pubmed/34374730 http://dx.doi.org/10.1155/2021/2782875 Text en Copyright © 2021 Pinger Li and Yinmei Lou. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Li, Pinger
Lou, Yinmei
Clinical Efficacy of Fuzheng Guben Anticancer Decoction Combined with Taxol in Treating Ovarian Carcinoma and Its Effect on Complication Incidence
title Clinical Efficacy of Fuzheng Guben Anticancer Decoction Combined with Taxol in Treating Ovarian Carcinoma and Its Effect on Complication Incidence
title_full Clinical Efficacy of Fuzheng Guben Anticancer Decoction Combined with Taxol in Treating Ovarian Carcinoma and Its Effect on Complication Incidence
title_fullStr Clinical Efficacy of Fuzheng Guben Anticancer Decoction Combined with Taxol in Treating Ovarian Carcinoma and Its Effect on Complication Incidence
title_full_unstemmed Clinical Efficacy of Fuzheng Guben Anticancer Decoction Combined with Taxol in Treating Ovarian Carcinoma and Its Effect on Complication Incidence
title_short Clinical Efficacy of Fuzheng Guben Anticancer Decoction Combined with Taxol in Treating Ovarian Carcinoma and Its Effect on Complication Incidence
title_sort clinical efficacy of fuzheng guben anticancer decoction combined with taxol in treating ovarian carcinoma and its effect on complication incidence
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709778/
https://www.ncbi.nlm.nih.gov/pubmed/34374730
http://dx.doi.org/10.1155/2021/2782875
work_keys_str_mv AT lipinger clinicalefficacyoffuzhenggubenanticancerdecoctioncombinedwithtaxolintreatingovariancarcinomaanditseffectoncomplicationincidence
AT louyinmei clinicalefficacyoffuzhenggubenanticancerdecoctioncombinedwithtaxolintreatingovariancarcinomaanditseffectoncomplicationincidence